DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp303a1 and cyp2p6

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_956433.1	Gene:	cyp2p6 / 393108	ZFINID:	ZDB-GENE-040426-790	Length:	496	Species:	Danio rerio

Alignment Length:	515	Identity:	141/515 - (27%)
Similarity:	244/515 - (47%)	Gaps:	51/515 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VIWIFCATLLAILFGGVRKPKRFPPGPAWYPIVGSA---------LQVSQLRCRLGMFCKVIDVF 60
            |::..|..||...:...:.||.|||||...||:|:.         |:|.:|..:.|....| .:|
Zfish    15 VLFFACVFLLLSNYIRNKTPKNFPPGPWPLPIIGNLYHIDFNKIHLEVEKLSEKYGSVVSV-HLF 78

  Fly    61 ARQYVNPYGFYGLKIGKDKVVIAYTNDAISEMMTNEDIDGRPD-GIFYRLRTFNSRLGVLLTDGE 124
            .::.|...|:..:|    :|.|          ...:::..||: .:.:.:...|   |::...|.
Zfish    79 GQRTVILNGYKQVK----EVYI----------QQGDNVADRPELPMIHDIAGDN---GLVAPSGY 126

  Fly   125 MWVEQRRFILRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVYVLNT 189
            .|.:||||.|..|:|||..:..:...::.|.    ..|.:.:....|:.  .:.|.|.:..:.|.
Zfish   127 KWKQQRRFALSTLRNFGLGKKSLEPSINLEC----HYLNEAISNENGRP--FDPHLLLNNAISNV 185

  Fly   190 LWCMLSGRRYEPGSPEITQLLETFFE-LFKNIDMVGALFSHFPLLRFIAP-----NFSGYNGFVE 248
            :..::.|.|::........||....| ::.:..:...|::.:|.:..:.|     |.:.:|..::
Zfish   186 ICVLVFGNRFDYSDHHFQTLLNDINEAMYLDGTIWAQLYNSYPRIMRLLPGPHKKNITLWNKVID 250

  Fly   249 SHRSLYTFMSKEIELHRLTYKNYDEPRDLMDSYLRAQDEGNDEKGMFSDQSLLAIC-LDMFLAGS 312
                   |..:.::.||:.| :...|||.:|.:|...::..|:.....|...|.|| ||:|:||:
Zfish   251 -------FARERVKEHRVDY-DPSNPRDYVDCFLAEMEKLKDDTAAGFDVENLCICTLDLFVAGT 307

  Fly   313 ETTNKSLGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFMLHT 377
            |||:.:|.:..::::..||||.:..:||..|:|..|.|..| ||..:||..|:..|..|...:..
Zfish   308 ETTSTTLSWSLLYMIKYPEIQAKVQEEIDRVIGSSRHPSVS-DRDNMPYTNAVIHEIQRFGNIAA 371

  Fly   378 FGIPHRAVCDTRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYL-FDGHLKLPEAFNPF 441
            ..:|..||.|.::..|.|||.|:||.....:|.:..::..|.||||..:| .:|..:..:||.||
Zfish   372 LNLPRAAVKDIQVGKYLIPKGTIVIGNLTSVLFDESEWETPHSFNPGHFLDAEGKFRRRDAFLPF 436

  Fly   442 GFGRHRCMGDLLGRQNLFMFTTTVLQNFKMVAIPGQVPEEVPLEGATAAVKPYDIMLVAR 501
            ..|:..|:|:.|.|..||:|.|::||:|...:..|..|......|.|.|.||:.:..|:|
Zfish   437 SLGKRVCLGEQLARMELFLFFTSLLQHFTFSSPAGVEPSFNYKLGTTRAPKPFKLCAVSR 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	126/469 (27%)
cyp2p6	NP_956433.1	p450	38..492	CDD:278495	132/486 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.820