DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp303a1 and cyp2aa3

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_938183.2	Gene:	cyp2aa3 / 386638	ZFINID:	ZDB-GENE-031030-8	Length:	496	Species:	Danio rerio

Alignment Length:	525	Identity:	146/525 - (27%)
Similarity:	239/525 - (45%)	Gaps:	77/525 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 IFCATLLAILFGGVR---KPKRFPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYVNPYG 69
            :|...::.:||...|   ..:|.||||...|.||:          :..|.|          ||.|
Zfish    17 LFLGLIILVLFEIFRIHSYKRRTPPGPTPLPFVGT----------IPHFLK----------NPLG 61

  Fly    70 F------YG----LKIGKDKVVIAYTNDAISEMMTNEDIDGRP---------DGIFYRLRTFNSR 115
            |      ||    :.:|:...:...|.....|.:..:...|:|         .|....:.|||
Zfish    62 FIRSMSQYGDMSTMYLGRKPAIFLNTIQLAKETLVQDTFSGKPYLPVIEWISKGFGIAMVTFN-- 124

  Fly   116 LGVLLTDGEMWVEQRRFILRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHD 180
                    ..|.:||||.|..|||||..:..:.|.|..|:..|:.::    ||..||.  ::.|.
Zfish   125 --------HSWRQQRRFALHTLKNFGLGKKSVEDRVLEESRYLIAEM----LKDEGKP--VDPHH 175

  Fly   181 LTSVYVLNTLWCMLSGRRYEPGSPEITQLLETFFELFKNIDMVGALFSH-FPLLRFIAPNFSGYN 244
            .....|.|.:..::.|.|:|..:.....||:.   |.:.|.:.|:.... |.|:.|| .:|.|.:
Zfish   176 PIQNAVSNIICSIVFGDRFEYNNKRFEYLLKM---LNETIMLAGSASGRIFNLVPFI-KHFPGPH 236

  Fly   245 GFVESHR-SLYTFMSKEIELHRLTYKNYDEPRDLMDSY-LRAQDEGNDEKGMFSDQSLLAICLDM 307
            ..::.:. .|..|:..|:|.||.|. :...|||.:|:| |..:.:..::...|.:.:|||...|:
Zfish   237 QKIKKNTDDLLIFLGDEVEEHRKTL-DPGSPRDFIDAYLLEIEKQKFNKDSTFHEGNLLASAGDL 300

  Fly   308 FLAGSETTNKSLGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRM 372
            |:||::||..::.:..:.|:..|::|||..:||.:|:|.:|:|... ||.:|||    ||..|..
Zfish   301 FMAGTDTTETTIRWGLLFLIQNPDVQERCHEEIVQVLGYDRLPSMD-DRDRLPY----TLATVHE 360

  Fly   373 FMLHTFGIP---HRAVCDTRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYLFDGHLKL 434
            ...:...||   |..:..|:|.||.||:.|.::...:.:..:...:..|:||||:.:|.|.|...
Zfish   361 IQRYGNIIPILIHETILPTKLQGYSIPQGTTIVTNIQAIFSSKDHWKHPDSFNPENFLEDRHFIK 425

  Fly   435 PEAFNPFGFGRHRCMGDLLGRQNLFMFTTTVLQNFKMVAIPGQVPEEVPLEGATAAV-KPYDIML 498
            ||:|..|..|...|:|::|.|..||:|.|::||.......|...|  :.::|....| .|....:
Zfish   426 PESFIMFSLGPRSCLGEILARTELFLFITSLLQRIHFSWPPDAKP--IDMDGIFGLVHSPQAFNV 488

  Fly   499 VAREQ 503
            :.|.:
Zfish   489 ICRSR 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	136/476 (29%)
cyp2aa3	NP_938183.2	p450	40..480	CDD:278495	138/487 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820