DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp303a1 and Cyp2t4

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_001093654.1	Gene:	Cyp2t4 / 384724	MGIID:	2686296	Length:	503	Species:	Mus musculus

Alignment Length:	515	Identity:	138/515 - (26%)
Similarity:	234/515 - (45%)	Gaps:	42/515 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 IFCATLLAIL--------FGGV-----RKPKRFPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDV 59
            :.|..||.:|        :|||     :..|..|||||..|::|:.||:..     |...:|:..
Mouse    10 VTCLALLLLLLILMLLLWWGGVVRRQAQMQKDLPPGPAPLPLLGNLLQLQS-----GDLDRVLME 69

  Fly    60 FARQYVNPYGFYGLKIGKDKVVIAYTNDAISE--MMTNEDIDGR-PDGIFYRLRTFNSRLGVLLT 121
            .:..: .|  .:.:.:|....|:....:|:.:  ::..:...|| ...:|.|....|   |::.:
Mouse    70 LSSHW-GP--VFTVWLGPLPAVVLCGYEALRDALVLQADAFSGRGAMAVFDRFTCGN---GIVFS 128

  Fly   122 DGEMWVEQRRFILRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVYV 186
            :|..|...|.|.|..|:..|..||.:.|.:..||.|:|.:.:..:      ....:...|....|
Mouse   129 NGPRWHSLRNFALGVLRELGVGRSTIEDRILEEAACVLDEFQATM------GAPFDPQQLLDSAV 187

  Fly   187 LNTLWCMLSGRRYEPGSPEITQLLETFFELFKNIDMVGA-LFSHFPLLRFIAPNFSGYNGFVESH 250
            .|.:..::.|:||:.|.||..:||..|.:.|..:....| :::.||......|  ..:|...::.
Mouse   188 SNVICTVVFGKRYDYGDPEFRRLLNLFSDNFCIMSSRWAEIYNMFPSFMDWIP--GPHNRIFKNF 250

  Fly   251 RSLYTFMSKEIELHRLTYKNYDEPRDLMDSYLRAQD-EGNDEKGMFSDQSLLAICLDMFLAGSET 314
            :.|..|:|::|:.|..: :...||||.:|.:|...| |..|.:..|.|::|:....|:|..|:||
Mouse   251 QELRLFISEQIQWHWQS-RQTGEPRDFIDCFLDQMDKEQQDLESHFQDETLVMTTHDLFFGGTET 314

  Fly   315 TNKSLGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFMLHTFG 379
            |:.:|.:..:.::..||:..:..:|:...||....|. ..||.:|||..|:..|..|...:...|
Mouse   315 TSTTLRYGLLIMLKYPEVAAKVQEELDATVGRTWAPR-IEDRARLPYTNAVLHEIQRFISVLPLG 378

  Fly   380 IPHRAVCDTRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYLFD-GHLKLPEAFNPFGF 443
            :|.....|..|..:.:.|.|.||........:|..|.||:.|||..:|.| |..:..:||.||..
Mouse   379 LPRALTRDVNLKNHFLHKGTFVIPLLVSAHRDPTQFKDPDHFNPTNFLDDHGEFQNNDAFMPFAL 443

  Fly   444 GRHRCMGDLLGRQNLFMFTTTVLQNFKMVAI--PGQVPEEVPLEGATAAVKPYDIMLVAR 501
            |:..|:|..|.|..:|:|.|.:||.|.::.:  |..:.......|.......:.:.||||
Mouse   444 GKRMCLGAGLARSEIFLFLTAILQKFSLLPVGSPANINLNPQCTGLGNVPPAFQLRLVAR 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	125/459 (27%)
Cyp2t4	NP_001093654.1	p450	63..498	CDD:278495	116/450 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010