Protein Alignment Cyp303a1 and Cyp2d12

DIOPT Version :10

• Sequence 1: NP_652070.1
• Gene: Cyp303a1 / 49165
• FlyBaseID: FBgn0001992
• Length: 503
• Species: Drosophila melanogaster
• Sequence 2: NP_958748.1
• Gene: Cyp2d12 / 380997
• MGIID: 88604
• Length: 504
• Species: Mus musculus
• Alignment Length: 517
• Identity: 141/517 - (27%)
• Similarity: 239/517 - (46%)
• Gaps: 45/517 - (8%)

  Fly     3 YTVIWIFCATLLAILFGGVRKPKR------FPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFA 61
            :|||:|....|:         .:|      :||||..:|::|:.|||........::
Mouse    15 FTVIFILLVDLM---------HRRQSWTSCYPPGPVPWPVLGNLLQVDLNNMPYSLY-------- 62

  Fly    62 RQYVNPYG-FYGLKIGKDKVVIAYTNDAISEMM--TNEDIDGRPDGIFYRLRTFNSR-LGVLLTD 122
             :..|.|| .:.|::....:|:.....|:.|::  ..||...||....:....|..| .|::...
Mouse    63 -KLQNRYGDVFSLQMAWKPMVVINRMKAMKEVLLTCGEDTADRPPVPIFEHLGFKPRSQGMIFAP 126

  Fly   123 -GEMWVEQRRFILRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVYV 186
             |..|.|||||.|..|:|||..|..:.:.|..||    ..|.|......|:.  |..:.:.....
Mouse   127 YGPEWREQRRFSLSSLRNFGLGRKSLEEWVIKEA----GHLCDAFTTQAGQY--INPNTMLKKAT 185

  Fly   187 LNTLWCMLSGRRYEPGSPEITQLLETFFELFKNID-MVGALFSHFPLLRFIAPNFSGYNGFVESH 250
            .|.:..::..||:|...|.:.::|:...:....:. ::..:.:.||:|..| |..:  :.|::|.
Mouse   186 CNVIASLIFARRFEYEDPYLIRMLKVLEDSLTELSGLIPEVINTFPILLHI-PRLA--DKFLQSQ 247

  Fly   251 RSLYTFMSKEIELHRLTYKNYDEPRDLMDSYLR--AQDEGNDEKGMFSDQSLLAICLDMFLAGSE 313
            :|....:...:..:|.|:.....||:|.|::|.  .:.:||.|.. |:|::|..:.:|:|.||..
Mouse   248 KSFIAIVDNLLTENRTTWDPAQSPRNLTDAFLAEIEKAKGNPESS-FNDENLRMVVIDLFTAGIL 311

  Fly   314 TTNKSLGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFMLHTF 378
            ||:.:|.:..:.::|.|::|.|..|||.||:|..|.||.: |:..:||..|:..|..|...:...
Mouse   312 TTSTTLSWALLLMILHPDVQRRVQQEIDEVIGQVRHPEMA-DQAHMPYTNAVIHEVQRFGDIVPL 375

  Fly   379 GIPHRAVCDTRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYL-FDGHLKLPEAFNPFG 442
            .:|.....|..:..:.|||.|:::.....:.::...:..|..|:|:.:| ..||....|||..|.
Mouse   376 HLPRITSRDIEVQDFLIPKGTILLPNMSSVHMDDTVWEKPLRFHPEHFLDAQGHFVKHEAFITFS 440

  Fly   443 FGRHRCMGDLLGRQNLFMFTTTVLQNFKMVAIPGQ-VPEEVPLEGATAAVKPYDIMLVAREQ 503
            .||..|:|:.|.|..||:|.|.:||.|......|| .|.:..:.....|..||.:..|.|||
Mouse   441 AGRRSCLGEPLARMELFLFFTCLLQRFSFSVPDGQPQPSDHRVFSIMVAPSPYQLCAVIREQ 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_652070.1	CYP15A1-like	68..496	CDD:410744	121/437 (28%)
Cyp2d12	NP_958748.1	CYP2D	68..495	CDD:410756	121/437 (28%)