DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp303a1 and cyp2x12

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	XP_005166578.1	Gene:	cyp2x12 / 325939	ZFINID:	ZDB-GENE-030131-4664	Length:	496	Species:	Danio rerio

Alignment Length:	510	Identity:	155/510 - (30%)
Similarity:	246/510 - (48%)	Gaps:	38/510 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TVIWIFC-ATLLAILFGGVRKPKRFPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYVNP 67
            |.:.:.| ...|..|...:|:||.||||||..|..|:.||::::..     .|.:|.||:.|.:.
Zfish     3 TALVLLCLGAFLLYLQVRIRRPKDFPPGPAPVPFFGNLLQLNRINP-----IKDLDKFAQHYGSI 62

  Fly    68 YGFYGLKIGKDKVVIAYTNDAISEMMTNE--DIDGRPDGIFYRLRTFNSRLGVLLTD-GEMWVEQ 129
            ||.|   ||....|:......|.|.:..:  :..|||:.:.  :.......||::.| ||.|.|.
Zfish    63 YGIY---IGSKPAVVLTGQKMIKEALITQAAEFAGRPNHMM--ISHITRSKGVIMADYGESWREH 122

  Fly   130 RRFILRHLKNFGFARSGMMDIVHNEA--TCLLQDLKDKVLKSGGKQTRIEMHDLTSVYVLNTLWC 192
            |||.|..|:|||..:..|...:..|.  .|||.:      :|.||.  |:...|......|.:..
Zfish   123 RRFALTTLRNFGLGKKSMEQRILEEVKHICLLLE------ESAGKS--IDPQHLYHQAASNIIAS 179

  Fly   193 MLSGRRYEPGSPEITQLLETFFELFK-NIDMVGALFSHFPLLR-FIAPNFSGYNGFVE-SHRSLY 254
            ::.|.|:.........|::|..:|.| .|.....|:...|:|| |..|.:..::.|.: :..||
Zfish   180 VIFGSRFNYKDEYFQTLIQTMEKLTKIAIGTWAMLYEIAPVLRIFPLPFWKAFHYFEKITRHSL- 243

  Fly   255 TFMSKEIELHRLTYKNYDEPRDLMDSYLRAQDEGNDEKGMFSDQSLLAICLDMFLAGSETTNKSL 319
                |.:|.|:.::. ..||:||:|.||....:..|::..|.:..::.:..|:||||:|||:.:|
Zfish   244 ----KVVEEHKKSFV-AGEPKDLIDCYLEEMKKRADQRTTFDEAQMVTLLFDLFLAGTETTSNTL 303

  Fly   320 GFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFMLHTFGIPHRA 384
            ....::|:....|||:..:||.||:| .|......||..:.:.:|:..|..|:..:....:.|.|
Zfish   304 RTLTLYLMTHTHIQEQCQREIDEVLG-ARDHVTYEDRNDMHFVQAVIHEGQRVADIVPLNVFHTA 367

  Fly   385 VCDTRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYLFD-GHLKLPEAFNPFGFGRHRC 448
            ..||:|.||.|||.|::|......|.....:..|..|||..:|.: |.....|||.||..|...|
Zfish   368 RTDTQLRGYSIPKGTIIIPYLSSSLREESQWKFPHEFNPQNFLNEKGEFVKNEAFMPFSAGPRVC 432

  Fly   449 MGDLLGRQNLFMFTTTVLQNFKMV--AIPGQVPEEVPLEGATAAVKPYDIMLVAR 501
            :|:.|.|..||:...|||:.|::|  ...|: |:...:.|.|.::|||.:::..|
Zfish   433 LGENLARMELFLILVTVLRKFRLVWPKDAGE-PDFTYIYGGTQSLKPYPMIVELR 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	140/462 (30%)
cyp2x12	XP_005166578.1	p450	28..466	CDD:278495	141/463 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H111164
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820