DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp303a1 and cyp2x10.2

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_001315444.1	Gene:	cyp2x10.2 / 322545	ZFINID:	ZDB-GENE-060818-12	Length:	496	Species:	Danio rerio

Alignment Length:	511	Identity:	155/511 - (30%)
Similarity:	242/511 - (47%)	Gaps:	40/511 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TVIWIFC-ATLLAILFGGVRKPKRFPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYVNP 67
            |.:.:.| ...|..|...:|:||.||||||..||.|:.||::::..     .|..|.||:.|.:.
Zfish     3 TALVLLCLGAFLLYLQLRIRRPKNFPPGPAPVPIFGNLLQLNRISP-----LKDFDKFAQHYGSI 62

  Fly    68 YGFYGLKIGKDKVVIAYTNDAISEMMTNE--DIDGRPDGIFYRLRTFNSRLGVLLTD-GEMWVEQ 129
            ||.|   ||....|:......|.|.:..:  :..||.:.:.:...|...  ||::.| ||.|.|.
Zfish    63 YGIY---IGSQPAVVLTGQKMIKEALITQAAEFSGRSNNMMFSHVTGGK--GVIMADYGESWREH 122

  Fly   130 RRFILRHLKNFGFARSGMMDIVHNEA--TCLLQDLKDKVLKSGGKQTRIEMHDLTSVYVLNTLWC 192
            |||.|..|:|||..:..|...:..|.  .|||.:      :|.||.  |:...|......|.:..
Zfish   123 RRFALTTLRNFGLGKKSMEQRILEEVKHICLLLE------ESAGKS--IDPQHLYHQAASNIIAS 179

  Fly   193 MLSGRRYEPGSPEITQLLETFFELFK-NIDMVGALFSHFPLLR-FIAPNFSGYNGF--VESHRSL 253
            ::.|.|:.........|:.:..:|.| .|.....|:...|:|| |..|....:..|  :..|
Zfish   180 VIFGSRFNYKDAYFQTLITSVEDLTKITIGPWAMLYEIAPVLRIFPLPFQKAFQYFEQITKH--- 241

  Fly   254 YTFMSKEIELHRLTYKNYDEPRDLMDSYLRAQDEGNDEKGMFSDQSLLAICLDMFLAGSETTNKS 318
               :.|.:|.|: |.:...|||||:|.||...:..:|.:..|.:..::.:..|:|:||:|||:.:
Zfish   242 ---VLKVVEEHK-TSRVAGEPRDLIDCYLEEMENKSDHRTSFDESQMVTLLFDLFIAGTETTSNT 302

  Fly   319 LGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFMLHTFGIPHR 383
            |....::|:....|||:..:||.||:| .|......||..:.:.:|:..|..|:..:....:.|.
Zfish   303 LRTLTLYLMTYTHIQEQCQREIDEVLG-ARDHVTYEDRNAMHFVQAVIHEGQRVADIAPLSMFHS 366

  Fly   384 AVCDTRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYLFD-GHLKLPEAFNPFGFGRHR 447
            |..||:|.||.|||.|::|......|.....:..|..|||..:|.: |.....:||.||..|...
Zfish   367 AKTDTQLRGYSIPKGTIIIPYLSSSLREEGQWKFPHEFNPQNFLNEKGEFVKNDAFMPFSAGPRV 431

  Fly   448 CMGDLLGRQNLFMFTTTVLQNFKMV--AIPGQVPEEVPLEGATAAVKPYDIMLVAR 501
            |:|:.|.|..||:...|||:.|::|  ...|: |:...:.|.|.:||||.:::..|
Zfish   432 CLGENLARMELFLILVTVLRRFRLVWPKDAGE-PDFTYIYGGTQSVKPYRVIVEPR 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	139/463 (30%)
cyp2x10.2	NP_001315444.1	p450	28..483	CDD:278495	146/481 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H111164
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820