DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp303a1 and Cyp2s1

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_001100965.1	Gene:	Cyp2s1 / 308445	RGDID:	1306078	Length:	499	Species:	Rattus norvegicus

Alignment Length:	513	Identity:	131/513 - (25%)
Similarity:	227/513 - (44%)	Gaps:	70/513 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 WIFCATLLAILFGGV--RKPKR--FPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYVNP 67
            |.....||.:|....  |.|.|  .||||...|::|:.||                      :.|
  Rat     7 WALLLALLLLLLALTLPRTPARGQLPPGPTPLPLLGNLLQ----------------------LRP 49

  Fly    68 YGFYG--LKIGKD-------------KVVIAYTNDAISEMMTN--EDIDGRPDGIFYRL-RTFNS 114
            ...|.  |::.|.             :||:...:|||.|.:..  |:..||  |....| :||:.
  Rat    50 GALYSGFLRLSKKYGPVFTVHLGPWRRVVVLVGHDAIREALGGQAEEFSGR--GTLATLDKTFDG 112

  Fly   115 RLGVLLTDGEMWVEQRRFILRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMH 179
            . ||...:||.|.:.|:|.|..|::.|..:....:::..|    :|:|.....::.|:.....|
  Rat   113 H-GVFFANGERWKQLRKFTLLALRDLGMGKREGEELIQEE----VQNLVKAFQRTEGRPFNPSM- 171

  Fly   180 DLTSVYVLNTLWCMLSGRRYEPGSPEITQLLETFFELFKNIDMV-GALFSHFPLLRFIAPNFSGY 243
             |.:....|.:..::.|.|......|...:::........|... |..:..|..|....|   |.
  Rat   172 -LLAQATSNVVCSLIFGIRLPYEDKEFQAVIQAASGTLLGISSPWGQAYEMFSWLLQPLP---GP 232

  Fly   244 NGFVESH-RSLYTFMSKEIELHRLTYKNYDEPRDLMDSYLRAQDEGNDEKGM-FSDQSLLAICLD 306
            :..::.| .:|..|..::::.|:.........||::|::|:...:..::.|. |::::||.....
  Rat   233 HTQLQHHLGTLAAFTIQQVQRHQGRSHTSGPARDVVDAFLQKMAQEKEDPGTEFTEKNLLMTVTY 297

  Fly   307 MFLAGSETTNKSLGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVR 371
            :..||:.|...::.:..:.|:..|::|:|..:|:.:.:|..|.|..| ||.:|||.:|:..||.|
  Rat   298 LLFAGTMTIGATIRYALLLLLKYPQVQKRVREELIQELGPSRTPSLS-DRVRLPYTDAVLHEAQR 361

  Fly   372 MFMLHTFGIPHRAVCDTRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYL-FDGHLKLP 435
            :..|...|:||.....|...||.:||.|.|......:|.:|..|.:||.|:|.|:| .||.::..
  Rat   362 LLALVPMGMPHTVTKTTSFRGYTLPKGTEVFPLIGSVLHDPAVFRNPEEFHPSRFLDDDGRIRKH 426

  Fly   436 EAFNPFGFGRHRCMGDLLGRQNLFMFTTTVLQNFKMVAIPGQVPEEVPLEGATAAVKP 493
            |||.|:..|:..|:|:.|.|..|::|.|::||.|.:         :.|......::||
  Rat   427 EAFLPYSLGKRVCLGEGLARAELWLFFTSILQAFSL---------DTPCPPGDLSLKP 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	121/473 (26%)
Cyp2s1	NP_001100965.1	p450	48..491	CDD:365848	116/450 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920