DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp303a1 and Cyp2c11

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_062057.2	Gene:	Cyp2c11 / 29277	RGDID:	2469	Length:	500	Species:	Rattus norvegicus

Alignment Length:	467	Identity:	131/467 - (28%)
Similarity:	232/467 - (49%)	Gaps:	51/467 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RFPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYVNPYG-FYGLKIGKDKVVIAYTNDAI 89
            :.||||...||:|:.||:         :.|.|....:::...|| .:.|.:|....|:.:..:|:
  Rat    28 KLPPGPTPLPIIGNTLQI---------YMKDIGQSIKKFSKVYGPIFTLYLGMKPFVVLHGYEAV 83

  Fly    90 SEMMTN--EDIDGRPDGIFYRLRTFNSRLGVLLTDGEMWVEQRRFILRHLKNFGFARSGMMDIVH 152
            .|.:.:  |:..||  |.|......|..|||:.::|..|.|.|||.:..|:.||..:..:.|.:.
  Rat    84 KEALVDLGEEFSGR--GSFPVSERVNKGLGVIFSNGMQWKEIRRFSIMTLRTFGMGKRTIEDRIQ 146

  Fly   153 NEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVYVL-----NTLWCMLSGRRYEPGSPEITQLLET 212
            .||.||:::|:    ||.|.       .....::|     |.:..::...|::...|....|:..
  Rat   147 EEAQCLVEELR----KSKGA-------PFDPTFILGCAPCNVICSIIFQNRFDYKDPTFLNLMHR 200

  Fly   213 F---FELFKN-----IDMVGALFSHFPLLRFIAPNFSGYNGFVESHRSLYTFMSKEIELHRLTYK 269
            |   |.||.:     .:...|:..:||         ..:|..:::...:..::.::::.|:.:.
  Rat   201 FNENFRLFSSPWLQVCNTFPAIIDYFP---------GSHNQVLKNFFYIKNYVLEKVKEHQESL- 255

  Fly   270 NYDEPRDLMDSYL-RAQDEGNDEKGMFSDQSLLAICLDMFLAGSETTNKSLGFCFMHLVLQPEIQ 333
            :.|.|||.:|.:| :.:.|.::.:..|:.:||:|...|||.||:|||:.:|.:..:.|:...::.
  Rat   256 DKDNPRDFIDCFLNKMEQEKHNPQSEFTLESLVATVTDMFGAGTETTSTTLRYGLLLLLKHVDVT 320

  Fly   334 ERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFMLHTFGIPHRAVCDTRLSGYEIPKD 398
            .:..:||:.|:|..|.| ..:||:::||.:|:..|..|...|....:||....|.:...|.|||.
  Rat   321 AKVQEEIERVIGRNRSP-CMKDRSQMPYTDAVVHEIQRYIDLVPTNLPHLVTRDIKFRNYFIPKG 384

  Fly   399 TMVIACFRGMLINPVDFPDPESFNPDRYLFD-GHLKLPEAFNPFGFGRHRCMGDLLGRQNLFMFT 462
            |.||.....:|.:..:||:||.|:|..:|.: |:.|..:.|.||..|:..|.|:.|.|..||:|.
  Rat   385 TNVIVSLSSILHDDKEFPNPEKFDPGHFLDERGNFKKSDYFMPFSAGKRICAGEALARTELFLFF 449

  Fly   463 TTVLQNFKMVAI 474
            ||:||||.:.::
  Rat   450 TTILQNFNLKSL 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	131/465 (28%)
Cyp2c11	NP_062057.2	p450	30..487	CDD:278495	131/465 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920