DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp303a1 and Cyp2b21

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_942028.1	Gene:	Cyp2b21 / 292728	RGDID:	735174	Length:	494	Species:	Rattus norvegicus

Alignment Length:	510	Identity:	149/510 - (29%)
Similarity:	250/510 - (49%)	Gaps:	53/510 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLAILFGGVRKPKRFPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYVNPYG-FYGLKIG 76
            ||.::.|........||||...|::|:.||:.    |.|:....|     |..:.|| ...:.:|
  Rat    16 LLLLIRGQGNGYGHLPPGPCPLPLLGNVLQMD----RRGLLKSFI-----QLRDKYGDVVTVHLG 71

  Fly    77 KDKVVIAYTNDAISEMMTN--EDIDGRPDGIFYRLRTFNSRLGVLLTDGEMWVEQRRFILRHLKN 139
            ...:|:.|..:.|.|.:.:  |...||  |....::......|::..:||.|...|||.|..:::
  Rat    72 PRPIVMLYGTETIREALVDHAEAFSGR--GTVAVVQPIIQDYGMIFANGERWKILRRFSLATMRD 134

  Fly   140 FGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVYVLNTLWCMLSGRRYEPGSP 204
            ||..:..:.:.:..||.||:::||.  .|.........:..:|:    |.:..::.|.|::....
  Rat   135 FGMGKRSVEERIKEEAQCLVEELKK--YKGAPLDPTFHLQCITA----NIICSIVFGERFDYTDH 193

  Fly   205 EITQLLETFFELFKNIDMVGALFSHFPLLRFIAPNFSGYNGFVE----SHR-------SLYTFMS 258
            :...||:.|:|:   :.:|.:         |.:..|..:.||::    :||       .:..|:.
  Rat   194 QFLHLLDLFYEI---LSLVSS---------FSSQVFELFTGFLKYFPGTHRHISKNIEEILNFIG 246

  Fly   259 KEIELHRLTYKNYDEPRDLMDSY-LRAQDEGNDEKGMFSDQSLLAICLDMFLAGSETTNKSLGFC 322
            ..:|.||.|. :...|||.:|:| ||.:.|..:....|..|:|:...|.:|.||:||::.:|.:.
  Rat   247 HCVEKHRATL-DPSTPRDFIDTYLLRMEKEKLNHHTEFHHQNLMMSVLSLFFAGTETSSTTLRYG 310

  Fly   323 FMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFMLHTFGIPHRAVCD 387
            |:.::..|.:.|:..:||.:|:|..|:|... ||.|:||.:|:..|..|...|...|:|||...|
  Rat   311 FLLMLKYPHVAEKVQKEIDQVIGSHRVPTLD-DRIKMPYTDAVIHEIQRFSDLVPIGLPHRVTKD 374

  Fly   388 TRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYL-FDGHLKLPEAFNPFGFGRHRCMGD 451
            |...||.:||:..|.......|.:|..|..|::|||:.:| .:|.||..|||.||..|:..|:|:
  Rat   375 TLFRGYLLPKNIEVYPILSSALHDPQYFEHPDTFNPEHFLDANGALKKNEAFLPFSTGKRVCLGE 439

  Fly   452 LLGRQNLFMFTTTVLQNFKMVAIPGQVPEEV---PLEGATAAVKP-YDIMLVARE 502
            .:.|..||:|.||:||||. |:.|.. |:::   |.|...|.:.| |.|..::|:
  Rat   440 GIARNELFLFFTTILQNFS-VSSPVS-PKDIDLTPKESGFAKIPPTYQICFLSRQ 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	138/467 (30%)
Cyp2b21	NP_942028.1	p450	42..488	CDD:278495	139/478 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820