DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp303a1 and Cyp2w1

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	XP_038945900.1	Gene:	Cyp2w1 / 288517	RGDID:	1305193	Length:	492	Species:	Rattus norvegicus

Alignment Length:	502	Identity:	139/502 - (27%)
Similarity:	227/502 - (45%)	Gaps:	51/502 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IW--IFCATLLAILFGGVRKP---KRFPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYV 65
            :|  :....|..:|.|..:.|   :::||||...|.:|: |.:      ||:..:  |....:..
  Rat     8 VWGILLLLGLWGLLRGCAQDPSMTRQWPPGPRPLPFLGN-LHL------LGVTHQ--DRALMELS 63

  Fly    66 NPYG-FYGLKIGKDKVVIAYTNDAISEMM--TNEDIDGRPDGIFYRLRTFNSRLGVLLTDGEMWV 127
            ..|| .:.:.:|..|.|:....:.:.|.:  |..::..||....::|  .....|:..:.|..|.
  Rat    64 ERYGPMFTIHLGSQKTVVLSGYEVVREALVGTGHELADRPPIPIFQL--IQRGGGIFFSSGVHWK 126

  Fly   128 EQRRFILRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVYVLNTLWC 192
            ..|:|.:|.|::.|..:..|:..|..|..|    ||.::...||:...:   .|......|..:.
  Rat   127 VARQFTVRTLQSLGIRQPPMVGKVLQELVC----LKGQLDSYGGQPFPL---TLLGWAPCNITFT 184

  Fly   193 MLSGRRYEPGSPEITQLLETFFELFKNIDMVG-ALFSHFP----LLRFIAPNFSGYNGFVESHRS 252
            :|.|:|::...|....||....::...:...| .||:.||    |||...|..|.    :|..|
  Rat   185 LLFGQRFDYQDPVFVSLLSLIDQVMVLLGSPGIQLFNTFPRLGALLRLHRPVLSK----IEEVR- 244

  Fly   253 LYTFMSKEIELHRLTYKNYDEPRDLMDSYL-RAQDEGNDEKGMFSDQSLLAICLDMFLAGSETTN 316
              |.:...:|..|....|....|..:::.| :.||:..|   |||:.::||..|||.:||:|||.
  Rat   245 --TILRTLLEAQRPPLPNGSPARSYVEALLQQGQDDPED---MFSEANVLACTLDMVMAGTETTA 304

  Fly   317 KSLGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFMLHTFGIP 381
            .:|.:....:|..|.:|.|..:|:..|:|..::|: ..|:..|||..|:..|..|...|    :|
  Rat   305 ATLQWAVFLMVKHPHVQGRVQEELDRVLGPGQLPQ-PEDQRALPYTSAVLHEVQRYITL----LP 364

  Fly   382 HRAVC---DTRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYL-FDGHLKLPEAFNPFG 442
            |...|   |.:|.||.:||.|.||.....:|::...:..|..|||:.:| ..|......||.||.
  Rat   365 HVPRCTAADIQLGGYLLPKGTPVIPLLTSVLLDKTQWETPSQFNPNHFLDAKGCFMKRGAFLPFS 429

  Fly   443 FGRHRCMGDLLGRQNLFMFTTTVLQNFKMVAIPGQVPEEVPLEGATA 489
            .||..|:|:.|.|..||:....:||.:.::..||..|.::.|..|.|
  Rat   430 TGRRVCVGESLARTELFLLFAGLLQQYHLLPPPGLSPADLDLRPAPA 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	130/464 (28%)
Cyp2w1	XP_038945900.1	cytochrome_P450	66..486	CDD:425388	124/435 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010