DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp303a1 and cyp2ad2

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_694486.1	Gene:	cyp2ad2 / 259306	ZFINID:	ZDB-GENE-020812-2	Length:	492	Species:	Danio rerio

Alignment Length:	522	Identity:	143/522 - (27%)
Similarity:	241/522 - (46%)	Gaps:	71/522 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 WIFCATLLAILFGGV--RKPKRFPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYVNPYG 69
            ||....:..|:...:  |.|..:||||...|.:|:.......: .:....||           ||
Zfish    15 WIIFFVVFLIIAEMIKNRTPSNYPPGPWPLPFLGTVFTKMDFK-NINKLAKV-----------YG 67

  Fly    70 -FYGLKIGKDKVVIAYTNDAISE-MMTNED--IDGRPDGIFYRLRTFNSRLGVLLTDGEMWVEQR 130
             .:.|::|.:|::|......:.| ::|..|  :...|..:|:::   ...:|:.:::|.:|...|
Zfish    68 KVFSLRVGSEKMIIVSGYKMVKEALVTQNDSFVLRPPVPLFHKV---YKGIGLTMSNGYIWRSHR 129

  Fly   131 RFILRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVYVL-----NTL 190
            ||...||:.||..:..:...:..|...|....|            .|......:::|     ||:
Zfish   130 RFAASHLRTFGEGKKNLELGIQQECVYLCDAFK------------AEKEPFNPIFILHGAVSNTV 182

  Fly   191 WCMLSGRRYEPGSPEITQLLETFFELFKNIDMVGA----LFSHFPLLRFIAPN-----FSGYNGF 246
            .|:..|:|::.......::|....:.   :.:.|:    |::.||.|....|.     ||.|...
Zfish   183 ACLTFGQRFDYNDEWYQEILRLDNQC---VQLAGSPRVQLYNAFPKLLDYLPGPHQKVFSNYKKI 244

  Fly   247 VESHRSLYTFMSKEIELHRLTYKNYD--EPRDLMDSYL-RAQDEGNDEKGMFSDQSLLAICLDMF 308
            .:|       :..||..||   :::|  .|||.:|:|| ..:.:.:|.:..|:.:||:..|||:.
Zfish   245 TQS-------LKDEIIKHR---EDWDPANPRDFIDNYLTEMEKKKSDPQAGFNIESLIISCLDIV 299

  Fly   309 LAGSETTNKSLGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMF 373
            .||:||...:|.:..:.::..||||::...||..|:|..|.| ...||..:||.||:..|..|..
Zfish   300 EAGTETGATTLRWGLLFMIKFPEIQKKVQAEIDRVIGQSRQP-CLDDRVNMPYTEAVLHEIQRFG 363

  Fly   374 MLHTFGIPHRAVCDTRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYL-FDGHLKLPEA 437
            .:...|.|.:|..||::..|.|||.|.:......:|.:|.::..|::|||..:| .:|..:..:|
Zfish   364 DVVPLGFPKQAAVDTKIGNYFIPKGTSITTNLSSVLHDPNEWETPDTFNPGHFLDKNGQFRKRDA 428

  Fly   438 FNPFGFGRHRCMGDLLGRQNLFMFTTTVLQNFKMVAIPGQVPEEVPLEGA---TAAVKPYDIMLV 499
            |.||..|:..|:|:||.|..||:|.|::||.|.:...||   ||..|||.   |.|..|:.|.:.
Zfish   429 FLPFSAGKRACVGELLARNVLFLFFTSLLQQFTLSKCPG---EEPSLEGEIWFTYAPAPFRISVS 490

  Fly   500 AR 501
            .|
Zfish   491 VR 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	128/473 (27%)
cyp2ad2	NP_694486.1	p450	38..470	CDD:278495	129/475 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920