DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp303a1 and Cyp2g1

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_036919.1	Gene:	Cyp2g1 / 25251	RGDID:	2477	Length:	494	Species:	Rattus norvegicus

Alignment Length:	515	Identity:	139/515 - (26%)
Similarity:	244/515 - (47%)	Gaps:	43/515 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 YTVIWIFCATLLAILFGGVRKPK--RFPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYV 65
            :::....|.:.|.||....|..:  :.||||...|.:|:.||| ::......|.|:    .::|.
  Rat     7 FSIFMTLCLSCLLILIAWKRTSRGGKLPPGPTPIPFLGNLLQV-RIDATFQSFLKL----QKKYG 66

  Fly    66 NPYGFYGLKIGKDKVVIAYTNDAISEMMTN--EDIDGRPDGIFYRLRTFNSRLGVLLTDGEMWVE 128
            :.:..|   .|...|||...::|:.|.:.:  :|..||  |....|.......|:.|::||.|..
  Rat    67 SVFTVY---FGPRPVVILCGHEAVKEALVDQADDFSGR--GEMPTLEKNFQGYGLALSNGERWKI 126

  Fly   129 QRRFILRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVYVLNTLWCM 193
            .|||.|..|:|||..:..:.:.:..||..||::| .||     |...|:.....|..|.|.:..:
  Rat   127 LRRFSLTVLRNFGMGKRSIEERIQEEAGYLLEEL-HKV-----KGAPIDPTFYLSRTVSNVICSV 185

  Fly   194 LSGRRYEPGSPEITQLLETFFELFKNI--------DMVGALFSHFPLLRFIAPNFSGYNGFVESH 250
            :.|:|::........|::...|.|..:        ||...:..:||         ..:|......
  Rat   186 VFGKRFDYEDQRFRSLMKMINESFVEMSMPWAQLYDMYWGVIQYFP---------GRHNRLYNLI 241

  Fly   251 RSLYTFMSKEIELHRLTYKNYDEPRDLMDSYL-RAQDEGNDEKGMFSDQSLLAICLDMFLAGSET 314
            ..|..|::..::::..:: :...|||.:|.:| :...:.:|....|:.::|:...|::|.||:||
  Rat   242 EELKDFIASRVKINEASF-DPSNPRDFIDCFLIKMYQDKSDPHSEFNLKNLVLTTLNLFFAGTET 305

  Fly   315 TNKSLGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFMLHTFG 379
            .:.:|.:.|:.|:..||::.:..:||.:|:|..|.|... ||.|:||.:|:..|..|:..:...|
  Rat   306 VSSTLRYGFLLLMKYPEVEAKIHEEINQVIGTHRTPRVD-DRAKMPYTDAVIHEIQRLTDIVPLG 369

  Fly   380 IPHRAVCDTRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYLFD-GHLKLPEAFNPFGF 443
            :||..:.||...||.:||.|.|......:|.:|..|..||:|.|..:|.: |..|..:||..|..
  Rat   370 VPHNVIRDTHFRGYFLPKGTDVYPLIGSVLKDPKYFRYPEAFYPQHFLDEQGRFKKNDAFVAFSS 434

  Fly   444 GRHRCMGDLLGRQNLFMFTTTVLQNFKMVAI--PGQVPEEVPLEGATAAVKPYDIMLVAR 501
            |:..|:|:.|.|..||::.|::||.|.:.::  |..:.....:.|.......|::..:||
  Rat   435 GKRICVGEALARMELFLYFTSILQRFSLRSLVPPADIDIAHKISGFGNIPPTYELCFMAR 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	130/465 (28%)
Cyp2g1	NP_036919.1	p450	34..491	CDD:278495	132/483 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820