DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp303a1 and Cyp2a2

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_036825.1	Gene:	Cyp2a2 / 24895	RGDID:	2464	Length:	492	Species:	Rattus norvegicus

Alignment Length:	461	Identity:	133/461 - (28%)
Similarity:	222/461 - (48%)	Gaps:	46/461 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 KRFPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFA--RQYVNPYG-FYGLKIGKDKVVIAYTN 86
            :|.||||...|.:|:.||::           :.||::  .|....|| .:.:.:|..::|:.|..
  Rat    30 ERLPPGPTPLPFIGNYLQLN-----------MKDVYSSITQLSERYGPVFTIHLGPRRIVVLYGY 83

  Fly    87 DAISEMMTN--EDIDGRPDGIFYRLRTFN---SRLGVLLTDGEMWVEQRRFILRHLKNFGFARSG 146
            ||:.|.:.:  |:..||.:     |.|||   ...|..|::.|.....|||.:..|::||..:..
  Rat    84 DAVKEALVDQAEEFSGRGE-----LPTFNILFKGYGFSLSNVEQAKRIRRFTIATLRDFGVGKRD 143

  Fly   147 MMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVYVLNTLWCMLSGRRYEPGSPEITQLLE 211
            :.:.:..||..|::.|:      |.....|:.....|..|.|.:..::.|.|::....|...|||
  Rat   144 VQECILEEAGYLIKTLQ------GTCGAPIDPSIYLSKTVSNVINSIVFGNRFDYEDKEFLSLLE 202

  Fly   212 TFFELFKNI---DMVGALFSHFPLLRFIAPNFSGYNGFVESHRSLYTFMSKEIELHRLTYKNYDE 273
            ...|:  ||   ...|.|:..|..:....|  ......::..:.|..||.:::..:..|. :.:.
  Rat   203 MIDEM--NIFAASATGQLYDMFHSVMKYLP--GPQQQIIKVTQKLEDFMIEKVRQNHSTL-DPNS 262

  Fly   274 PRDLMDSYL-RAQDEG--NDEKGMFSDQSLLAICLDMFLAGSETTNKSLGFCFMHLVLQPEIQER 335
            ||:.:||:| |.|:|.  |.|   |...:|:...|.:..||:.:.:.:|...|:.|:..|:::.:
  Rat   263 PRNFIDSFLIRMQEEKYVNSE---FHMNNLVMSSLGLLFAGTGSVSSTLYHGFLLLMKHPDVEAK 324

  Fly   336 AFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFMLHTFGIPHRAVCDTRLSGYEIPKDTM 400
            ..:||:.|:|..|.|:: .|..|:||.:|:..|..|...|...|||.|.:.:|...|:.:||.|.
  Rat   325 VHEEIERVIGRNRQPQY-EDHMKMPYTQAVINEIQRFSNLAPLGIPRRIIKNTTFRGFFLPKGTD 388

  Fly   401 VIACFRGMLINPVDFPDPESFNPDRYLFD-GHLKLPEAFNPFGFGRHRCMGDLLGRQNLFMFTTT 464
            |......::..|..||:.:.|||..:|.| |.||...||.||..|:..|:||.|.:..||:..||
  Rat   389 VFPIIGSLMTEPKFFPNHKDFNPQHFLDDKGQLKKNAAFLPFSIGKRFCLGDSLAKMELFLLLTT 453

  Fly   465 VLQNFK 470
            :||||:
  Rat   454 ILQNFR 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	132/458 (29%)
Cyp2a2	NP_036825.1	p450	33..489	CDD:278495	132/458 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820