DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp303a1 and Cyp2b1

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	XP_038950984.1	Gene:	Cyp2b1 / 24300	RGDID:	2466	Length:	517	Species:	Rattus norvegicus

Alignment Length:	535	Identity:	161/535 - (30%)
Similarity:	261/535 - (48%)	Gaps:	71/535 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLAILFGG----VR-KPK---RFPPGPAWYPIVGSALQVSQLRCRLGMFCK-----------VID 58
            |||:|.|.    || .||   .|||||...|::|:.||:.: ...|..|.:           |:.
  Rat     8 LLALLVGFLLLLVRGHPKSRGNFPPGPRPLPLLGNLLQLDR-GGLLNSFMQPGPPQPTDLQGVVV 71

  Fly    59 VFARQYVNP-------YG-FYGLKIGKDKVVIAYTNDAISEMMTN--EDIDGRPDGIFYRLRTFN 113
            ....|:::|       || .:.:.:|...||:....|.|.|.:..  ||..||  |....:....
  Rat    72 ASTMQHLSPAVKLREKYGDVFTVHLGPRPVVMLCGTDTIKEALVGQAEDFSGR--GTIAVIEPIF 134

  Fly   114 SRLGVLLTDGEMWVEQRRFILRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEM 178
            ...||:..:||.|...|||.|..:::||..:..:.:.:..||.||:::|:    ||.|  ..::.
  Rat   135 KEYGVIFANGERWKALRRFSLATMRDFGMGKRSVEERIQEEAQCLVEELR----KSQG--APLDP 193

  Fly   179 HDLTSVYVLNTLWCMLSGRRYEPGSPEITQLLETFFELFKNIDMVGALFSHFPLLRFIAPNFSGY 243
            ..|......|.:..::.|.|::....:..:|||.|:..|       :|.|.|.     :..|..:
  Rat   194 TFLFQCITANIICSIVFGERFDYTDRQFLRLLELFYRTF-------SLLSSFS-----SQVFEFF 246

  Fly   244 NGFVE----SHR-------SLYTFMSKEIELHRLTYKNYDEPRDLMDSY-LRAQDEGNDEKGMFS 296
            :||::    :||       .:..::...:|.||.|. :...|||.:|:| ||.:.|.::...:|.
  Rat   247 SGFLKYFPGAHRQISKNLQEILDYIGHIVEKHRATL-DPSAPRDFIDTYLLRMEKEKSNHHTVFH 310

  Fly   297 DQSLLAICLDMFLAGSETTNKSLGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPY 361
            .::|:...|.:|.||:||::.:|.:.|:.::..|.:.|:..:||.:|:|..|:|... ||:|:||
  Rat   311 HENLMISLLSLFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPTLD-DRSKMPY 374

  Fly   362 CEAITLEAVRMFMLHTFGIPHRAVCDTRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRY 426
            .:|:..|..|...|...|:|||...||...||.:||:|.|.......|.:|..|..|:||||:.:
  Rat   375 TDAVIHEIQRFSDLVPIGVPHRVTKDTMFRGYLLPKNTEVYPILSSALHDPQYFDHPDSFNPEHF 439

  Fly   427 L-FDGHLKLPEAFNPFGFGRHRCMGDLLGRQNLFMFTTTVLQNFKMVAIPGQVPEEV---PLEGA 487
            | .:|.||..|||.||..|:..|:|:.:.|..||:|.||:||||.:.:  ...|:::   |.|..
  Rat   440 LDANGALKKSEAFMPFSTGKRICLGEGIARNELFLFFTTILQNFSVSS--HLAPKDIDLTPKESG 502

  Fly   488 TAAVKP-YDIMLVAR 501
            ...:.| |.|...||
  Rat   503 IGKIPPTYQICFSAR 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	143/485 (29%)
Cyp2b1	XP_038950984.1	CYP2B	88..512	CDD:410765	135/447 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820