DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp303a1 and Cyp1a1

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_036672.3	Gene:	Cyp1a1 / 24296	RGDID:	2458	Length:	524	Species:	Rattus norvegicus

Alignment Length:	512	Identity:	142/512 - (27%)
Similarity:	219/512 - (42%)	Gaps:	91/512 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 VRKPKRFPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYVNPY-------GFYG----LK 74
            |.|..:.||||...|.:|..|.:.:                    ||:       ..||    ::
  Rat    37 VPKGLKSPPGPWGLPFIGHVLTLGK--------------------NPHLSLTKLSQQYGDVLQIR 81

  Fly    75 IGKDKVVIAYTNDAISEMMT--NEDIDGRPDGIFYRL------RTFNSRLGVLLTDGEMWVEQRR 131
            ||...||:....:.|.:.:.  .:|..||||...:.|      .|||.      ..|.:|..:||
  Rat    82 IGSTPVVVLSGLNTIKQALVKQGDDFKGRPDLYSFTLIANGQSMTFNP------DSGPLWAARRR 140

  Fly   132 FILRHLKNFGFARSGMMDIVHNEATCLLQD--------LKDKVLKSGGKQTRIEMHDLTSVYVLN 188
            .....||:|..|....:     .::|.|::        |..|..|...:....:......|.|.|
  Rat   141 LAQNALKSFSIASDPTL-----ASSCYLEEHVSKEAEYLISKFQKLMAEVGHFDPFKYLVVSVAN 200

  Fly   189 TLWCMLSGRRYEPGSPEITQLLETFFELFKNIDMVGALFSHFPLLRFIAPNFSGYNGFVESHRSL 253
            .:..:..||||:....|:..::....| |..:...|......|:||:: || |..:.|.:.::..
  Rat   201 VICAICFGRRYDHDDQELLSIVNLSNE-FGEVTGSGYPADFIPILRYL-PN-SSLDAFKDLNKKF 262

  Fly   254 YTFMSKEIELHRLTYKNYDEP--RDLMDSYL-RAQDEGNDEKG--MFSDQSLLAICLDMFLAGSE 313
            |:||.|.|:.|   |:.:::.  ||:.||.: ..||...||..  ..||..::.|..|:|.||.:
  Rat   263 YSFMKKLIKEH---YRTFEKGHIRDITDSLIEHCQDRRLDENANVQLSDDKVITIVFDLFGAGFD 324

  Fly   314 TTNKSLGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFMLHTF 378
            |...::.:..|:||..|.||.:..:|:..|:|.:|.|..| ||.:|||.||..||..|......|
  Rat   325 TITTAISWSLMYLVTNPRIQRKIQEELDTVIGRDRQPRLS-DRPQLPYLEAFILETFRHSSFVPF 388

  Fly   379 GIPHRAVCDTRLSGYEIPKDTMVIACFRGMLINPVD-------FPDPESFNPDRYL-----FDGH 431
            .|||..:.||.|:|:.|||...|       .:|...       :.||..|.|:|:|     .|.|
  Rat   389 TIPHSTIRDTSLNGFYIPKGHCV-------FVNQWQVNHDQELWGDPNEFRPERFLTSSGTLDKH 446

  Fly   432 LKLPEAFNPFGFGRHRCMGDLLGRQNLFMFTTTVLQNFKMVAIPGQVPEEVPLEGAT 488
            |.  |....||.|:.:|:|:.:||..:|:|...:||..:....||:..:..|..|.|
  Rat   447 LS--EKVILFGLGKRKCIGETIGRLEVFLFLAILLQQMEFNVSPGEKVDMTPAYGLT 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	137/495 (28%)
Cyp1a1	NP_036672.3	Mitochondrial targeting signal. /evidence=ECO:0000269\|PubMed:19401463, ECO:0000269\|PubMed:9348277	33..44		2/6 (33%)
Cyp1a1	NP_036672.3	CYP1A	74..509	CDD:410769	131/455 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920