DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp303a1 and Cyp2d34

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	XP_030104365.1	Gene:	Cyp2d34 / 223706	MGIID:	2385022	Length:	519	Species:	Mus musculus

Alignment Length:	534	Identity:	147/534 - (27%)
Similarity:	243/534 - (45%)	Gaps:	64/534 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 YTVIWIFCATLLAILFGGVRKPKRFPPGPAWYPIVGSALQVS---------QLRCRLGMFCKVID 58
            :|||::.   |:.::........|:||||..:|::|:.|||.         :|:.|.|      |
Mouse    15 FTVIFLI---LVDLMHRRQHWTSRYPPGPVPWPVLGNLLQVDLDNIPYSLYKLQNRYG------D 70

  Fly    59 VFARQYVNPYGFYGLKIGKDKVVIAYTNDAISEMMT---NEDIDGRPDGIFYRLRTFNSRLGVLL 120
            ||:           |::....||:.....|:.|::.   .:..|..|..||..|...:...||:|
Mouse    71 VFS-----------LQMAWKPVVVINGLKAMQEVLLTCGKDTADHPPVPIFEYLGFKSKSQGVVL 124

  Fly   121 TD-GEMWVEQRRFILRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSV 184
            .. |..|.|||:|.:..|:|||..:..:.:.|..||    :.|.|......|:.  |..:.:.:.
Mouse   125 ASYGPEWREQRQFSVSTLRNFGLGKKSLEEWVTKEA----KHLCDAFTARAGQS--INPNTMLNN 183

  Fly   185 YVLNTLWCMLSGRRYEPGSPEITQLLETFFELFKNI-DMVGALFSHFPLLRFIAPNFSGYNGFVE 248
            .|.|.:..::..||:|...|.:.::|:...|..|.: ..:..:.:.||:|..| |..:  :...:
Mouse   184 AVCNVIASLIFARRFEYEDPFLIRMLKMREESLKEVTGFIPGVLNTFPILLRI-PGLA--DMVFQ 245

  Fly   249 SHRSLYTFMSKEIELHRLTYKNYDEPRDLMDSYLR--AQDEGNDEKGMFSDQSLLAICLDMFLAG 311
            |.::....:...:..:|.|:.....||:|.|::|.  .:.:||.|.. |:|::|..:..|:|.||
Mouse   246 SQKTFMAILDNLVTENRTTWDPDQPPRNLADAFLAEIQKAKGNPESS-FNDENLCMVVSDLFTAG 309

  Fly   312 SETTNKSLGFCFMHLVLQPEIQ---------------ERAFQEIKEVVGLERIPEWSRDRTKLPY 361
            ..||:.:|....:.::|.|::|               .|..|||..|:|..|.||.: |:.::||
Mouse   310 MVTTSTTLSCALLLMILHPDVQREPGWGWEGGRGTIPSRVQQEIDAVIGQVRCPEMA-DQARMPY 373

  Fly   362 CEAITLEAVRMFMLHTFGIPHRAVCDTRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRY 426
            ..|:..|..|...:....||.....|..:..:.|||.|::|.....||.:...:..|..|.|:.:
Mouse   374 TNAVIHEVQRFGDIIPLNIPRITSRDIEVQDFLIPKGTILIPNMSSMLKDETVWEKPLRFYPEHF 438

  Fly   427 L-FDGHLKLPEAFNPFGFGRHRCMGDLLGRQNLFMFTTTVLQNFKMVAIPGQ-VPEEVPLEGATA 489
            | ..||...||||.||..||..|:|:.|.|..||:|.|.:||.|......|| .|.:..:.....
Mouse   439 LDAQGHFVKPEAFMPFSAGRRSCLGEPLARMELFLFFTCLLQRFSFSVPAGQPQPSDHRIFAIPV 503

  Fly   490 AVKPYDIMLVAREQ 503
            |..||.:..:.|||
Mouse   504 APYPYQVCAIMREQ 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	135/484 (28%)
Cyp2d34	XP_030104365.1	p450	37..511	CDD:365848	139/501 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820