DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp303a1 and Cyp2c22

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_612521.2	Gene:	Cyp2c22 / 171518	RGDID:	620368	Length:	489	Species:	Rattus norvegicus

Alignment Length:	511	Identity:	134/511 - (26%)
Similarity:	246/511 - (48%)	Gaps:	49/511 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IWIFCATLLAILFGGVRKPKRFPPGPAWYPIVGSALQV-----SQLRCRLGMFCKVIDVFARQYV 65
            ||:.|...| .|:......::.||||...||.|:.|||     |:..|.|          |::|.
  Rat     9 IWLSCLVFL-FLWNQHHVRRKLPPGPTPLPIFGNILQVGVKNISKSMCML----------AKEYG 62

  Fly    66 NPYGFYGLKIGKDKVVIAYTNDAISEMMTN--EDIDGRPDGIFYRLRTFNSRLGVLLTDGEMWVE 128
            ..:..|   :|....|:.|..:.:.|.:.:  |:...:.....  |...:..||::.::||:|.:
  Rat    63 PVFTMY---LGMKPTVVLYGYEVLKEALIDRGEEFSDKMHSSM--LSKVSQGLGIVFSNGEIWKQ 122

  Fly   129 QRRFILRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVYVLNTLWCM 193
            .|||.|..|::.|..:..:.:.:..|...||:.|:    |:.|  :..:...|.:....|.:..:
  Rat   123 TRRFSLMVLRSMGMGKRTIENRIQEEVVYLLEALR----KTNG--SPCDPSFLLACVPCNVISSV 181

  Fly   194 LSGRRYEPGSPEITQLLETFFELFKNIDMVGA----LFSHFPLLRFIAPNFSGYNGFVESHRSLY 254
            :...|::....:..:.:|.|   ...|:::.:    |.|.:|:|.:: |..  :|.|::......
  Rat   182 IFQHRFDYSDEKFQKFIENF---HTKIEILASPWAQLCSAYPVLYYL-PGI--HNKFLKDVTEQK 240

  Fly   255 TFMSKEIELHRLTYKNYDEPRDLMDSYL-RAQDEGNDEKGMFSDQSLLAICLDMFLAGSETTNKS 318
            .|:..||..||.:. |...|:|.:|.:| :.:.|.::||..|:..:|:....|:|.||:|||:.:
  Rat   241 KFILMEINRHRASL-NLSNPQDFIDYFLIKMEKEKHNEKSEFTMDNLIVTIGDLFGAGTETTSST 304

  Fly   319 LGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFMLHTFGIPHR 383
            :.:..:.|:..||:..:..:||..|:|..|.| ..:||..:||.:|:..|..|........:|.:
  Rat   305 IKYGLLLLLKYPEVTAKIQEEITRVIGRHRRP-CMQDRNHMPYTDAVLHEIQRYIDFVPIPLPRK 368

  Fly   384 AVCDTRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYLFD-GHLKLPEAFNPFGFGRHR 447
            ...|....||.|||.|.|:||....|.:..:||:||.|:|..:|.: |:.|..:.|..|..||..
  Rat   369 TTQDVEFRGYHIPKGTSVMACLTSALHDDKEFPNPEKFDPGHFLDEKGNFKKSDYFMAFSAGRRA 433

  Fly   448 CMGDLLGRQNLFMFTTTVLQNFKMVAIPGQVPEEV---PLE-GATAAVKPYDIMLV 499
            |:|:.|.|..:|:..|::||:|.:..:..  ||::   |:: |..:...|:::..:
  Rat   434 CIGEGLARMEMFLILTSILQHFTLKPLVN--PEDIDTTPVQPGLLSVPPPFELCFI 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	124/464 (27%)
Cyp2c22	NP_612521.2	CYP2C-like	61..484	CDD:410758	115/443 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010