DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp303a1 and Cyp2t1

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_599196.2	Gene:	Cyp2t1 / 171380	RGDID:	620086	Length:	497	Species:	Rattus norvegicus

Alignment Length:	525	Identity:	148/525 - (28%)
Similarity:	241/525 - (45%)	Gaps:	61/525 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TVIWIFCATLLAILFGGV------RKPKRFPPGPAWYPIVGSALQVS---------QLRCRLGMF 53
            |::.:...||:.:.:|.:      |..|..|||||..|::|:.||:.         :|..|.|
  Rat     7 TLLLLLILTLMLMSWGWLAHQARARMQKDLPPGPAPLPLLGNLLQLQSGHLDRVLMELSSRWG-- 69

  Fly    54 CKVIDVF--ARQYVNPYGFYGLKIGKDKVVIAYTNDAISEMMTNEDIDGRPD-GIFYRLRTFNSR 115
             .|..|:  .|..|...|:..|   :|.:|:  ..||.|         ||.. .:|.|   |...
  Rat    70 -PVFTVWLGPRPAVVLSGYAAL---RDALVL--QADAFS---------GRGSMAVFER---FTHG 116

  Fly   116 LGVLLTDGEMWVEQRRFILRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHD 180
            .|::.::|..|...|.|.|..||.||...|.:.:.:..|..|:|.:.:..:      ....:...
  Rat   117 NGIVFSNGPRWRTLRNFALGALKEFGVGTSTIEERILEETACVLDEFQATM------GAPFDPRR 175

  Fly   181 LTSVYVLNTLWCMLSGRRYEPGSPEITQLLETFFELFKNI-DMVGALFSHFP-LLRFI-APNFSG 242
            |....|.|.:..::.|:||..|.||..:||:.|.:.|:.: ...|..::.|| .:.:| .|:...
  Rat   176 LLDNAVSNVICTVVFGKRYNYGDPEFLRLLDLFSDNFRIMSSRWGETYNMFPSFMDWIPGPHHRI 240

  Fly   243 YNGFVESHRSLYTFMSKEIELHRLTYKNYDEPRDLMDSYLRAQD-EGNDEKGMFSDQSLLAICLD 306
            :..|.|    |..|:|::|:.||.: :...||||.:|.:|...| |..|.:..|.|::|:....:
  Rat   241 FKNFQE----LRLFISEQIQWHRQS-RQTGEPRDFIDCFLEQMDKEHQDPESHFQDETLVMTTHN 300

  Fly   307 MFLAGSETTNKSLGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVR 371
            :|..|:|||:.:|.:..:.::..||:..:..:|:...||..|.|..: ||..|||..|:..|..|
  Rat   301 LFFGGTETTSTTLRYGLLIMLKYPEVAAKVQEELDATVGRTRAPSLA-DRAHLPYTNAVLHEIQR 364

  Fly   372 MFMLHTFGIPHRAVCDTRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYLFD-GHLKLP 435
            ...:...|:|...:.|..|..:.:.|.|.||........:|..|.||:.|||..:|.| |..:..
  Rat   365 FISVLPLGLPRALIRDVNLRNHFLHKGTFVIPLLVSAHRDPTQFKDPDHFNPTNFLDDQGEFQNN 429

  Fly   436 EAFNPFGFGRHRCMGDLLGRQNLFMFTTTVLQNFKMVAIPGQVPEEVPL----EGATAAVKPYDI 496
            :||.||..|:..|:|..|.|..:|:|.|.:||.|.:  :|...|.::.|    .|.......:.:
  Rat   430 DAFMPFAPGKRMCLGAGLARSEIFLFLTAILQKFSL--LPVGSPADIDLTPQCTGLGNVPPAFQL 492

  Fly   497 MLVAR 501
            .||||
  Rat   493 RLVAR 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	135/468 (29%)
Cyp2t1	NP_599196.2	cytochrome_P450	68..492	CDD:425388	127/457 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010