Protein Alignment Cyp303a1 and Cyp2t1

DIOPT Version :10

• Sequence 1: NP_652070.1
• Gene: Cyp303a1 / 49165
• FlyBaseID: FBgn0001992
• Length: 503
• Species: Drosophila melanogaster
• Sequence 2: NP_599196.2
• Gene: Cyp2t1 / 171380
• RGDID: 620086
• Length: 497
• Species: Rattus norvegicus
• Alignment Length: 525
• Identity: 148/525 - (28%)
• Similarity: 241/525 - (45%)
• Gaps: 61/525 - (11%)

  Fly     4 TVIWIFCATLLAILFGGV------RKPKRFPPGPAWYPIVGSALQVS---------QLRCRLGMF 53
            |::.:...||:.:.:|.:      |..|..|||||..|::|:.||:.         :|..|.|
  Rat     7 TLLLLLILTLMLMSWGWLAHQARARMQKDLPPGPAPLPLLGNLLQLQSGHLDRVLMELSSRWG-- 69

  Fly    54 CKVIDVF--ARQYVNPYGFYGLKIGKDKVVIAYTNDAISEMMTNEDIDGRPD-GIFYRLRTFNSR 115
             .|..|:  .|..|...|:..|   :|.:|:  ..||.|         ||.. .:|.|   |...
  Rat    70 -PVFTVWLGPRPAVVLSGYAAL---RDALVL--QADAFS---------GRGSMAVFER---FTHG 116

  Fly   116 LGVLLTDGEMWVEQRRFILRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHD 180
            .|::.::|..|...|.|.|..||.||...|.:.:.:..|..|:|.:.:..:      ....:...
  Rat   117 NGIVFSNGPRWRTLRNFALGALKEFGVGTSTIEERILEETACVLDEFQATM------GAPFDPRR 175

  Fly   181 LTSVYVLNTLWCMLSGRRYEPGSPEITQLLETFFELFKNI-DMVGALFSHFP-LLRFI-APNFSG 242
            |....|.|.:..::.|:||..|.||..:||:.|.:.|:.: ...|..::.|| .:.:| .|:...
  Rat   176 LLDNAVSNVICTVVFGKRYNYGDPEFLRLLDLFSDNFRIMSSRWGETYNMFPSFMDWIPGPHHRI 240

  Fly   243 YNGFVESHRSLYTFMSKEIELHRLTYKNYDEPRDLMDSYLRAQD-EGNDEKGMFSDQSLLAICLD 306
            :..|.|    |..|:|::|:.||.: :...||||.:|.:|...| |..|.:..|.|::|:....:
  Rat   241 FKNFQE----LRLFISEQIQWHRQS-RQTGEPRDFIDCFLEQMDKEHQDPESHFQDETLVMTTHN 300

  Fly   307 MFLAGSETTNKSLGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVR 371
            :|..|:|||:.:|.:..:.::..||:..:..:|:...||..|.|..: ||..|||..|:..|..|
  Rat   301 LFFGGTETTSTTLRYGLLIMLKYPEVAAKVQEELDATVGRTRAPSLA-DRAHLPYTNAVLHEIQR 364

  Fly   372 MFMLHTFGIPHRAVCDTRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYLFD-GHLKLP 435
            ...:...|:|...:.|..|..:.:.|.|.||........:|..|.||:.|||..:|.| |..:..
  Rat   365 FISVLPLGLPRALIRDVNLRNHFLHKGTFVIPLLVSAHRDPTQFKDPDHFNPTNFLDDQGEFQNN 429

  Fly   436 EAFNPFGFGRHRCMGDLLGRQNLFMFTTTVLQNFKMVAIPGQVPEEVPL----EGATAAVKPYDI 496
            :||.||..|:..|:|..|.|..:|:|.|.:||.|.:  :|...|.::.|    .|.......:.:
  Rat   430 DAFMPFAPGKRMCLGAGLARSEIFLFLTAILQKFSL--LPVGSPADIDLTPQCTGLGNVPPAFQL 492

  Fly   497 MLVAR 501
            .||||
  Rat   493 RLVAR 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_652070.1	CYP15A1-like	68..496	CDD:410744	122/437 (28%)
Cyp2t1	NP_599196.2	cytochrome_P450	68..492	CDD:477761	127/457 (28%)