DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp303a1 and CYP2J2

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_000766.2	Gene:	CYP2J2 / 1573	HGNCID:	2634	Length:	502	Species:	Homo sapiens

Alignment Length:	478	Identity:	145/478 - (30%)
Similarity:	239/478 - (50%)	Gaps:	54/478 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ATLLAILFGGVRKPKRFPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYVNPYGFYGLKI 75
            |.|||..|...|:||.:||||...|.:|:...|...:..|     .:.:|.::|.|   .:.|::
Human    27 AFLLAADFLKRRRPKNYPPGPWRLPFLGNFFLVDFEQSHL-----EVQLFVKKYGN---LFSLEL 83

  Fly    76 GKDKVVIAYTNDAISEMMTNED--IDGRP-----DGIFYRLRTFNSRLGVLLTDGEMWVEQRRFI 133
            |....|:......|.|.:.:.|  ...||     :.||       .:.|::::.|:.|.|||||.
Human    84 GDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIF-------KKNGLIMSSGQAWKEQRRFT 141

  Fly   134 LRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVYVLNTLWCMLSGRR 198
            |..|:|||..:..:.:.:..||    |.|.:.:.:..|:.  .:.|...:..|.|.:..:..|.|
Human   142 LTALRNFGLGKKSLEERIQEEA----QHLTEAIKEENGQP--FDPHFKINNAVSNIICSITFGER 200

  Fly   199 YEPGSPEITQLLE-----TFFELFKNIDMVGALFSHFP-LLRFI-APN---FSGYNGFVESHRSL 253
            :|.......|||:     |:.|..|...    |::.|| :::|: .|:   ||.:       :.|
Human   201 FEYQDSWFQQLLKLLDEVTYLEASKTCQ----LYNVFPWIMKFLPGPHQTLFSNW-------KKL 254

  Fly   254 YTFMSKEIELHRLTYKNYDEPRDLMDSYLR--AQDEGNDEKGMFSDQSLLAICLDMFLAGSETTN 316
            ..|:|..|:.||..: |..|.||.:|:||:  ::..||.... |.:::|:...||:|.||:|||:
Human   255 KLFVSHMIDKHRKDW-NPAETRDFIDAYLKEMSKHTGNPTSS-FHEENLICSTLDLFFAGTETTS 317

  Fly   317 KSLGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFMLHTFGIP 381
            .:|.:..:::.|.|||||:...||..|:|..:.|. :..|..:||..|:..|..||..:....:|
Human   318 TTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPS-TAARESMPYTNAVIHEVQRMGNIIPLNVP 381

  Fly   382 HRAVCDTRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYLFDGHLKLPEAFNPFGFGRH 446
            .....||.|:||.:||.||::.....:..:|.::..|::||||.:|.:|..|..|||.||..|:.
Human   382 REVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLENGQFKKREAFMPFSIGKR 446

  Fly   447 RCMGDLLGRQNLFMFTTTVLQNF 469
            .|:|:.|.|..||:|.|:::|.|
Human   447 ACLGEQLARTELFIFFTSLMQKF 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	137/461 (30%)
CYP2J2	NP_000766.2	p450	44..497	CDD:365848	137/461 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820