DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp303a1 and CYP2F1

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	XP_016881873.1	Gene:	CYP2F1 / 1572	HGNCID:	2632	Length:	573	Species:	Homo sapiens

Alignment Length:	452	Identity:	115/452 - (25%)
Similarity:	204/452 - (45%)	Gaps:	33/452 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VIWIFCATLLAILFGGVRKPKRFPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYVNPYG 69
            ::.:..|.:..:|....|...:.||||....|:|:.|    |.|...|...:..: :::|.:
Human    83 ILLLLLALVCLLLTLSSRDKGKLPPGPRPLSILGNLL----LLCSQDMLTSLTKL-SKEYGS--- 139

  Fly    70 FYGLKIGKDKVVIAYTNDAISEMMTN--EDIDGRPDGIFYRLRTFNSRLGVLLTDGEMWVEQRRF 132
            .|.:.:|..:||:.....|:.|.:.:  |:..||.|  :.....|....|:..:.|:.|...|:|
Human   140 MYTVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGD--YPAFFNFTKGNGIAFSSGDRWKVLRQF 202

  Fly   133 ILRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVY---VLNTLWCML 194
            .::.|:|||..:..:.:.:..|.:.||.:|         ::|..|..|.|.|.   |.|.:..:|
Human   203 SIQILRNFGMGKRSIEERILEEGSFLLAEL---------RKTEGEPFDPTFVLSRSVSNIICSVL 258

  Fly   195 SGRRYEPGSPEITQLLETFFELFKNIDMV-GALFSHFPLLRFIAPNFSGYNGFVESHRSLYTFMS 258
            .|.|::.....:..::....:.|:.:... |.|:..||.|....|  ..:....::.:.|...::
Human   259 FGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVP--GPHQRIFQNFKCLRDLIA 321

  Fly   259 KEIELHRLTYKNYDEPRDLMDSYL-RAQDEGNDEKGMFSDQSLLAICLDMFLAGSETTNKSLGFC 322
            ..:..|:.:. :...|||.:..:| :..:|..|....|...:||....::...|::|.:.:|...
Human   322 HSVHDHQASL-DPRSPRDFIQCFLTKMAEEKEDPLSHFHMDTLLMTTHNLLFGGTKTVSTTLHHA 385

  Fly   323 FMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFMLHTFGIPHRAVCD 387
            |:.|:..|::|.|..:||..|||..|:|. .:||..:||.:|:..|..|...:....:|||...|
Human   386 FLALMKYPKVQARVQEEIDLVVGRARLPA-LKDRAAMPYTDAVIHEVQRFADIIPMNLPHRVTRD 449

  Fly   388 TRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYLFDGH--LKLPEAFNPFGFGRHR 447
            |...|:.|||.|.||.....:..:|..|..|:.|||:.:| |.:  .|...||.||..|..|
Human   450 TAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFL-DANQSFKKSPAFMPFSAGEGR 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	112/429 (26%)
CYP2F1	XP_016881873.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920