Protein Alignment Cyp303a1 and CYP2D6

DIOPT Version :9

• Sequence 1: NP_001285977.1
• Gene: Cyp303a1 / 49165
• FlyBaseID: FBgn0001992
• Length: 503
• Species: Drosophila melanogaster
• Sequence 2: NP_000097.3
• Gene: CYP2D6 / 1565
• HGNCID: 2625
• Length: 497
• Species: Homo sapiens
• Alignment Length: 527
• Identity: 153/527 - (29%)
• Similarity: 235/527 - (44%)
• Gaps: 71/527 - (13%)

  Fly     5 VIWIFCATLLAILFGGVRKPKRFPPGPAWYPIVGSALQV---------SQLRCRLGMFCKVIDVF 60
            ::.|| ..|:.::....|...|:||||...|.:|:.|.|         .|||.|.|      |||
Human    12 IVAIF-LLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFG------DVF 69

  Fly    61 ARQYVNPYGFYGLKIGKDKVVIAYTNDAISEMMT--NEDIDGRPDGIFYRLRTFNSR-LGVLLTD 122
            :           |::....||:.....|:.|.:.  .||...||.....::..|..| .||.|..
Human    70 S-----------LQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLAR 123

  Fly   123 -GEMWVEQRRFILRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVYV 186
             |..|.|||||.:..|:|.|..:..:...|..||.||.....:    ..|:..|  .:.|....|
Human   124 YGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFAN----HSGRPFR--PNGLLDKAV 182

  Fly   187 LNTLWCMLSGRRYEPGSPEITQLLETFFELFKN--------IDMVGALFSHFP-----LLRFIAP 238
            .|.:..:..|||:|...|...:||:...|..|.        ::.|..|. |.|     :|||
Human   183 SNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLL-HIPALAGKVLRF--- 243

  Fly   239 NFSGYNGFVESHRSLYTFMSKEIELHRLTYKNYDEPRDLMDSYLRAQD--EGNDEKGMFSDQSLL 301
                       .::..|.:.:.:..||:|:.....||||.:::|...:  :||.|.. |:|::|.
Human   244 -----------QKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESS-FNDENLR 296

  Fly   302 AICLDMFLAGSETTNKSLGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAIT 366
            .:..|:|.||..||:.:|.:..:.::|.|::|.|..|||.:|:|..|.||.. |:..:||..|:.
Human   297 IVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMG-DQAHMPYTTAVI 360

  Fly   367 LEAVRMFMLHTFGIPHRAVCDTRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYL-FDG 430
            .|..|...:...|:.|....|..:.|:.|||.|.:|.....:|.:...:..|..|:|:.:| ..|
Human   361 HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQG 425

  Fly   431 HLKLPEAFNPFGFGRHRCMGDLLGRQNLFMFTTTVLQNFKMVAIPGQV-PEEVPLEGATAAVKPY 494
            |...||||.||..||..|:|:.|.|..||:|.|::||:|......||. |....:.....:..||
Human   426 HFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPY 490

  Fly   495 DIMLVAR 501
            ::..|.|
Human   491 ELCAVPR 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	143/481 (30%)
CYP2D6	NP_000097.3	p450	58..493	CDD:278495	138/474 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820