Protein Alignment Cyp303a1 and CYP2D7

DIOPT Version :9

• Sequence 1: NP_001285977.1
• Gene: Cyp303a1 / 49165
• FlyBaseID: FBgn0001992
• Length: 503
• Species: Drosophila melanogaster
• Sequence 2: NP_001335315.1
• Gene: CYP2D7 / 1564
• HGNCID: 2624
• Length: 516
• Species: Homo sapiens
• Alignment Length: 546
• Identity: 152/546 - (27%)
• Similarity: 237/546 - (43%)
• Gaps: 90/546 - (16%)

  Fly     5 VIWIFCATLLAILFGGVRKPKRFPPGPAWYPIVGSALQV---------SQLRCRLGMFCKVIDVF 60
            ::.|| ..|:.::....|...|:||||...|.:|:.|.|         .|||.|.|      |||
Human    12 IVAIF-LLLVDLMHRHQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFG------DVF 69

  Fly    61 ARQYVNPYGFYGLKIGKDKVVIAYTNDAISEMMT--NEDIDGRPDGIFYRLRTFNSR-LGVLLTD 122
            :           |::....||:.....|:.|.|.  .||...||....|::..|..| .||:|:.
Human    70 S-----------LQLAWTPVVVLNGLAAVREAMVTRGEDTADRPPAPIYQVLGFGPRSQGVILSR 123

  Fly   123 -GEMWVEQRRFILRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVYV 186
             |..|.|||||.:..|:|.|..:..:...|..||.||.....|:    .|:..|  .:.|....|
Human   124 YGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFADQ----AGRPFR--PNGLLDKAV 182

  Fly   187 LNTLWCMLSGRRYEPGSPEITQLLETFFELFKN--------IDMVGALFSHFP-----LLRFIAP 238
            .|.:..:..|||:|...|...:||:...|..|.        ::.|..| .|.|     :|||
Human   183 SNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVL-PHIPALAGKVLRF--- 243

  Fly   239 NFSGYNGFVESHRSLYTFMSKEIELHRLTYKNYDEPRDLMDSYLRAQD--EGNDEKGMFSDQSLL 301
                       .::..|.:.:.:..||:|:.....||||.:::|..::  :|:.|.. |:|::|.
Human   244 -----------QKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAKKEKAKGSPESS-FNDENLR 296

  Fly   302 AICLDMFLAGSETTNKSLGFCFMHLVLQPEIQE-------------------RAFQEIKEVVGLE 347
            .:..::||||..||:.:|.:..:.::|..::|.                   |..|||.:|:|..
Human   297 IVVGNLFLAGMVTTSTTLAWGLLLMILHLDVQRGRRVSPGCSPIVGTHVCPVRVQQEIDDVIGQV 361

  Fly   348 RIPEWSRDRTKLPYCEAITLEAVRMFMLHTFGIPHRAVCDTRLSGYEIPKDTMVIACFRGMLINP 412
            |.||.. |:..:|...|:..|......:...|:.|....|..:.|:.|||.|.:|.....:|.:.
Human   362 RRPEMG-DQAHMPCTTAVIHEVQHFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDE 425

  Fly   413 VDFPDPESFNPDRYL-FDGHLKLPEAFNPFGFGRHRCMGDLLGRQNLFMFTTTVLQNFKMVAIPG 476
            ..:..|..|:|:.:| ..||...||||.||..||..|:|:.|.|..||:|.|::||:|......|
Human   426 AVWKKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVAAG 490

  Fly   477 QV-PEEVPLEGATAAVKPYDIMLVAR 501
            |. |....:........||::..|.|
Human   491 QPRPSHSRVVSFLVTPSPYELCAVPR 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	142/500 (28%)
CYP2D7	NP_001335315.1	p450	58..512	CDD:306555	137/493 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920