Protein Alignment Cyp303a1 and CYP2C8

DIOPT Version :9

• Sequence 1: NP_001285977.1
• Gene: Cyp303a1 / 49165
• FlyBaseID: FBgn0001992
• Length: 503
• Species: Drosophila melanogaster
• Sequence 2: NP_000761.3
• Gene: CYP2C8 / 1558
• HGNCID: 2622
• Length: 490
• Species: Homo sapiens
• Alignment Length: 484
• Identity: 136/484 - (28%)
• Similarity: 254/484 - (52%)
• Gaps: 41/484 - (8%)

  Fly     5 VIWIFCATLLAILFGGVR---KPKRFPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYVN 66
            |:.:.|.:.: :||...|   :.::.||||...||:|:.||:.     :...||....|::.|..
Human     5 VVLVLCLSFM-LLFSLWRQSCRRRKLPPGPTPLPIIGNMLQID-----VKDICKSFTNFSKVYGP 63

  Fly    67 PYGFYGLKIGKDKVVIAYTNDAISEMM--TNEDIDGRPDG-IFYRLRTFNSRLGVLLTDGEMWVE 128
            .:..|   .|.:.:|:.:..:|:.|.:  ..|:..||.:. |..|:   ...||::.::|:.|.|
Human    64 VFTVY---FGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRI---TKGLGIISSNGKRWKE 122

  Fly   129 QRRFILRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVYVL-----N 188
            .|||.|..|:|||..:..:.|.|..||.||:::|         ::|:....|.|  ::|     |
Human   123 IRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEEL---------RKTKASPCDPT--FILGCAPCN 176

  Fly   189 TLWCMLSGRRYEPGSPEITQLLETFFELFKNIDMVG-ALFSHFPLLRFIAPNFSGYNGFVESHRS 252
            .:..::..:|::........|::.|.|.|:.::... .:.::||||....|  ..:|..:::...
Human   177 VICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFP--GTHNKVLKNVAL 239

  Fly   253 LYTFMSKEIELHRLTYKNYDEPRDLMDSYL-RAQDEGNDEKGMFSDQSLLAICLDMFLAGSETTN 316
            ..:::.::::.|:.:. :.:.|||.:|.:| :.:.|.:::|..|:.::|:....|:|:||:|||:
Human   240 TRSYIREKVKEHQASL-DVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTS 303

  Fly   317 KSLGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFMLHTFGIP 381
            .:|.:..:.|:..||:..:..:||..|:|..|.| ..:||:.:||.:|:..|..|...|...|:|
Human   304 TTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSP-CMQDRSHMPYTDAVVHEIQRYSDLVPTGVP 367

  Fly   382 HRAVCDTRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYL-FDGHLKLPEAFNPFGFGR 445
            |....||:...|.|||.|.::|....:|.:..:||:|..|:|..:| .:|:.|..:.|.||..|:
Human   368 HAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGK 432

  Fly   446 HRCMGDLLGRQNLFMFTTTVLQNFKMVAI 474
            ..|.|:.|.|..||:|.||:||||.:.::
Human   433 RICAGEGLARMELFLFLTTILQNFNLKSV 461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	131/458 (29%)
CYP2C8	NP_000761.3	p450	30..487	CDD:278495	131/458 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920