DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp303a1 and CYP2A7

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_000755.2	Gene:	CYP2A7 / 1549	HGNCID:	2611	Length:	494	Species:	Homo sapiens

Alignment Length:	497	Identity:	133/497 - (26%)
Similarity:	238/497 - (47%)	Gaps:	53/497 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VIWIFCATLLAILFGGVRKPKR--FPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYVNP 67
            |..:.|.|::.::....::..|  .||||...|.:|:.||::...     .|..|..|:..| .|
Human     9 VALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEH-----ICDSIMKFSECY-GP 67

  Fly    68 YGFYGLKIGKDKVVIAYTNDAISEMMTN--EDIDGRP-----DGIFYRLRTFNSRLGVLLTDGEM 125
              .:.:.:|..:||:...:||:.|.:.:  |:..||.     |.:|       ...||..::||.
Human    68 --VFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVF-------KGYGVAFSNGER 123

  Fly   126 WVEQRRFILRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVYVLNTL 190
            ..:..||.:..|::||..:.|:.:.:..|:..|::.::..      ....|:.....|..|.|.:
Human   124 AKQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRST------HGANIDPTFFLSRTVSNVI 182

  Fly   191 WCMLSGRRYEPGSPEITQLLETFFELF--------KNIDMVGALFSHFPLLRFIAPNFSGYNGFV 247
            ..::.|.|::....|...||.....:|        :..:|..::..|.|     .|....:
Human   183 SSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLP-----GPQQQAF---- 238

  Fly   248 ESHRSLYTFMSKEIELHRLTYKNYDEPRDLMDSYL-RAQDEGNDEKGMFSDQSLLAICLDMFLAG 311
            :..:.|..|::|::| |.....:.:.|:|.:||:| ..|:|..:....|..::|:...|::|:||
Human   239 KLLQGLEDFIAKKVE-HNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAG 302

  Fly   312 SETTNKSLGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFMLH 376
            :||.:.:|.:.|:.|:..||::.:..:||..|:|..|.|:: .||||:||.||:..|..|...:.
Human   303 TETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKF-EDRTKMPYMEAVIHEIQRFGDVI 366

  Fly   377 TFGIPHRAVCDTRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYLFD-GHLKLPEAFNP 440
            ...:..|...||:...:.:||.|.|......:|.:|..|.:|:.|||..:|.| |..|..:||.|
Human   367 PMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDAFVP 431

  Fly   441 FGFGRHRCMGDLLGRQNLFMFTTTVLQNFKMVAIPGQVPEEV 482
            |..|:..|.|:.|.|..||:|.|||:|||::.:  .|.|:::
Human   432 FSIGKRNCFGEGLARMELFLFFTTVMQNFRLKS--SQSPKDI 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	128/468 (27%)
CYP2A7	NP_000755.2	p450	34..491	CDD:278495	129/472 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820