DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp303a1 and CYP2A6

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_000753.3	Gene:	CYP2A6 / 1548	HGNCID:	2610	Length:	494	Species:	Homo sapiens

Alignment Length:	521	Identity:	141/521 - (27%)
Similarity:	252/521 - (48%)	Gaps:	59/521 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VIWIFCATLLAIL-FGGVRKPK-RFPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYVNP 67
            |..:.|.|::.:: ....||.| :.||||...|.:|:.||::..:    |:..::.:..|
Human     9 VALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQ----MYNSLMKISER----- 64

  Fly    68 YG-FYGLKIGKDKVVIAYTNDAISEMMTN--EDIDGRP-----DGIFYRLRTFNSRLGVLLTDGE 124
            || .:.:.:|..:||:...:||:.|.:.:  |:..||.     |.:|       ...||:.::||
Human    65 YGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVF-------KGYGVVFSNGE 122

  Fly   125 MWVEQRRFILRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVYVLNT 189
            ...:.|||.:..|::||..:.|:.:.:..||..|:..|:.    :||  ..|:.....|..|.|.
Human   123 RAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRG----TGG--ANIDPTFFLSRTVSNV 181

  Fly   190 LWCMLSGRRYEPGSPEITQLLETFFELF--------KNIDMVGALFSHFPLLRFIAPNFSGYNGF 246
            :..::.|.|::....|...||.....:|        :..:|..::..|.|     .|....:
Human   182 ISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLP-----GPQQQAF--- 238

  Fly   247 VESHRSLYTFMSKEIELHRLTYKNYDEPRDLMDSYL-RAQDEGNDEKGMFSDQSLLAICLDMFLA 310
             :..:.|..|::|::| |.....:.:.|||.:||:| |.|:|..:....|..::|:...|::|:.
Human   239 -QLLQGLEDFIAKKVE-HNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIG 301

  Fly   311 GSETTNKSLGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFML 375
            |:||.:.:|.:.|:.|:..||::.:..:||..|:|..|.|:: .||.|:||.||:..|..|...:
Human   302 GTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKF-EDRAKMPYMEAVIHEIQRFGDV 365

  Fly   376 HTFGIPHRAVCDTRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYLFD-GHLKLPEAFN 439
            ....:..|...||:...:.:||.|.|......:|.:|..|.:|:.|||..:|.: |..|..:||.
Human   366 IPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFV 430

  Fly   440 PFGFGRHRCMGDLLGRQNLFMFTTTVLQNFKMVAIPGQVPEEVPLE----GATAAVKPYDIMLVA 500
            ||..|:..|.|:.|.|..||:|.|||:|||::.:  .|.|:::.:.    |.....:.|.:..:.
Human   431 PFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKS--SQSPKDIDVSPKHVGFATIPRNYTMSFLP 493

  Fly   501 R 501
            |
Human   494 R 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	131/469 (28%)
CYP2A6	NP_000753.3	p450	34..491	CDD:365848	134/491 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820