Protein Alignment Cyp303a1 and CYP1A1

DIOPT Version :10

• Sequence 1: NP_652070.1
• Gene: Cyp303a1 / 49165
• FlyBaseID: FBgn0001992
• Length: 503
• Species: Drosophila melanogaster
• Sequence 2: NP_000490.1
• Gene: CYP1A1 / 1543
• HGNCID: 2595
• Length: 512
• Species: Homo sapiens
• Alignment Length: 521
• Identity: 144/521 - (27%)
• Similarity: 226/521 - (43%)
• Gaps: 81/521 - (15%)

  Fly     8 IFCATLLAILFGGVRKPK--RFPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYVNPY-- 68
            |||.....|.....:.||  :.||||..:|::|..|.:.:                    ||:
Human    18 IFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGK--------------------NPHLA 62

  Fly    69 -----GFYG----LKIGKDKVVIAYTNDAISEMMT--NEDIDGRPDGIFYRLRTFNSRLGVLLTD 122
                 ..||    ::||...||:....|.|.:.:.  .:|..||||...:.|.:....:......
Human    63 LSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDS 127

  Fly   123 GEMWVEQRRFILRHLKNFGFARSG-------MMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHD 180
            |.:|..:||.....||:|..|...       :.:.|..||..|:..|::.:...|    ....:.
Human   128 GPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPG----HFNPYR 188

  Fly   181 LTSVYVLNTLWCMLSGRRYEPGSPEITQLLETFFELFKNIDMV---GALFSHFPLLRFIAPNFSG 242
            ...|.|.|.:..:..||||:....|:..|:    .|..|...|   |......|:||:: ||.|
Human   189 YVVVSVTNVICAICFGRRYDHNHQELLSLV----NLNNNFGEVVGSGNPADFIPILRYL-PNPS- 247

  Fly   243 YNGFVESHRSLYTFMSKEIELHRLTYKNYDEP--RDLMDSYL-RAQDEGNDEKG--MFSDQSLLA 302
            .|.|.:.:...|:||.|.::.|   ||.:::.  ||:.||.: ..|::..||..  ..||:.::.
Human   248 LNAFKDLNEKFYSFMQKMVKEH---YKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIIN 309

  Fly   303 ICLDMFLAGSETTNKSLGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITL 367
            |.||:|.||.:|...::.:..|:||:.|.:|.:..:|:..|:|..|.|..| ||:.|||.||..|
Human   310 IVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS-DRSHLPYMEAFIL 373

  Fly   368 EAVRMFMLHTFGIPHRAVCDTRLSGYEIPKDTMVIACFRGMLINPVD-------FPDPESFNPDR 425
            |..|......|.|||....||.|.|:.|||.       |.:.:|...       :.:|..|.|:|
Human   374 ETFRHSSFVPFTIPHSTTRDTSLKGFYIPKG-------RCVFVNQWQINHDQKLWVNPSEFLPER 431

  Fly   426 YLF-DGHLK--LPEAFNPFGFGRHRCMGDLLGRQNLFMFTTTVLQNFKMVAIPGQVPEEVPLEGA 487
            :|. ||.:.  |.|....||.|:.:|:|:.:.|..:|:|...:||..:.....|...:..|:.|.
Human   432 FLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGL 496

  Fly   488 T 488
            |
Human   497 T 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_652070.1	CYP15A1-like	68..496	CDD:410744	129/459 (28%)
CYP1A1	NP_000490.1	Mitochondrial targeting signal. /evidence=ECO:0000250|UniProtKB:P00185	29..40		2/10 (20%)
		CYP1A	70..505	CDD:410769	129/449 (29%)