DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp303a1 and Cyp2j5

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_034137.1	Gene:	Cyp2j5 / 13109	MGIID:	1270149	Length:	501	Species:	Mus musculus

Alignment Length:	481	Identity:	132/481 - (27%)
Similarity:	232/481 - (48%)	Gaps:	54/481 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VIWIFCATLLAILFGGVRKPKRFPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYVNPYG 69
            |.::|...:|.     .|.||.:||||...|.||:..|:...:..|.:         :|:|..||
Mouse    26 VTFLFLINILR-----SRHPKNYPPGPWRLPFVGNFFQIDTKQTHLVL---------QQFVKKYG 76

  Fly    70 -FYGLKIGKDKVVIAYTNDAISEMMTNEDIDGRPDGIFYRLRT-----FNSRLGVLLTDGEMWVE 128
             .:.|::|:..||:......|.||.|:.|     .....|..|     ...:.|:::::|:.|.|
Mouse    77 NVFSLELGQSPVVVVSGLPLIKEMFTHLD-----QNFVNRFMTPVRERITGKNGLVVSNGQTWKE 136

  Fly   129 QRRFILRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVYVLNTLWCM 193
            |||..|..|:|||..:..:.:.:..|...|::.::::    ||:.....:..:.:  |.|.:..:
Mouse   137 QRRLALMALRNFGLGKKSLEERIQEETHHLVEAIREE----GGQPFNPHLKLINA--VSNIICSV 195

  Fly   194 LSGRRYEPGS---PEITQLLETFFELFKNIDMVGALFSHFPLLRFIAPNFSGYNGFVESHRSLY- 254
            ..|.|::...   .|:.|||:....|..:  ..|.|::.||.:....|.         .|:.::
Mouse   196 TFGERFDYEDCQFQELLQLLDETMHLMGS--SAGQLYNGFPCIMKYLPG---------PHQKIFR 249

  Fly   255 ------TFMSKEIELHRLTYKNYDEPRDLMDSYLRAQDEGNDEKGMFSDQSLLAICLDMFLAGSE 313
                  .|:|..::.|...: |.|||||.:|::|....:..|....|::::|::..||:||.|:|
Mouse   250 NWGKLKLFVSHIVKKHEKDW-NPDEPRDFIDAFLIEMQKDPDRTTSFNEENLISTTLDLFLGGTE 313

  Fly   314 TTNKSLGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFMLHTF 378
            ||:.:|.:..:::...|||||....||..|:|.:|....| ||..:||..|:..|..||..:...
Mouse   314 TTSSTLRWALLYMSSYPEIQENVQAEIDRVIGHKRQVSLS-DRESMPYTNAVIHEVQRMGNIVPL 377

  Fly   379 GIPHRAVCDTRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYLFDGHLKLPEAFNPFGF 443
            ........||:.:|:.:||.||::.....:..:|.::..||.|||:.:|.:|..|..|:|.||..
Mouse   378 NSSREVTVDTKFNGFHLPKGTMILTNLTALHRDPKEWATPEVFNPEHFLENGQFKKRESFLPFSM 442

  Fly   444 GRHRCMGDLLGRQNLFMFTTTVLQNF 469
            |:..|:|:.|.:..||:|.:.::|.|
Mouse   443 GKRACLGEQLAKSELFIFFSALMQKF 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	126/458 (28%)
Cyp2j5	NP_034137.1	p450	44..496	CDD:278495	126/458 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820