DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp303a1 and Cyp2d9

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_034136.2	Gene:	Cyp2d9 / 13105	MGIID:	88606	Length:	504	Species:	Mus musculus

Alignment Length:	519	Identity:	152/519 - (29%)
Similarity:	244/519 - (47%)	Gaps:	49/519 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 YTVIWIFCATLLAILFGGVRKPKRFPPGPAWYPIVGSALQVS---------QLRCRLGMFCKVID 58
            :|||:|.   |:.:.....|...|:||||..:|::|:.|||.         :|:.|.|      |
Mouse    15 FTVIFIL---LVDLTHQRQRWTSRYPPGPVPWPVLGNLLQVDLGNMPYSLYKLQNRYG------D 70

  Fly    59 VFARQYVNPYGFYGLKIGKDKVVIAYTNDAISEMM--TNEDIDGRPD-GIFYRLRTFNSRLGVLL 120
            ||:           |::....:|:.....|:.||:  ..||...||. .||..|.......||:|
Mouse    71 VFS-----------LQMAWKPMVVINGLKAMKEMLLTCGEDTADRPPVPIFEYLGVKPGSQGVVL 124

  Fly   121 TD-GEMWVEQRRFILRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSV 184
            .. |..|.|||||.:..|:|||..:..:.|.|..||    ..|.|......|:.  |..:.:.:.
Mouse   125 APYGPEWREQRRFSVSTLRNFGLGKKSLEDWVTKEA----NHLCDAFTAQAGQP--INPNPMLNK 183

  Fly   185 YVLNTLWCMLSGRRYEPGSPEITQLLETFFELFKNID-MVGALFSHFPLLRFIAPNFSGYNGFVE 248
            ...|.:..::..||:|...|.:.::|:...:....:. ::..:.:.||:|..| |..:  :..::
Mouse   184 STCNVIASLIFARRFEYEDPFLIRMLKVLEQSLTEVSGLIPEVLNAFPILLRI-PRLA--DKALQ 245

  Fly   249 SHRSLYTFMSKEIELHRLTYKNYDEPRDLMDSYLR--AQDEGNDEKGMFSDQSLLAICLDMFLAG 311
            ..:|....:...:..:|.|:.....||:|.|::|.  .:.:||.|.. |:|::||.:..|:|.||
Mouse   246 GQKSFIAILDNLLTENRTTWDPVQAPRNLTDAFLAEIEKAKGNPESS-FNDENLLMVVRDLFGAG 309

  Fly   312 SETTNKSLGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFMLH 376
            ..||:.:|.:..|.::|.|::|.|..|||.||:|..|.||.: |:..:||..|:..|..|...:.
Mouse   310 MLTTSTTLSWALMLMILHPDVQRRVQQEIDEVIGQVRHPEMA-DQAHMPYTNAVIHEVQRFGDIV 373

  Fly   377 TFGIPHRAVCDTRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYL-FDGHLKLPEAFNP 440
            ...:|.....|..:..:.|||.|:::.....||.:...:..|..|:|:.:| ..||...||||.|
Mouse   374 PVNLPRITSHDIEVQDFLIPKGTILLPNMSSMLKDESVWEKPLRFHPEHFLDAQGHFVKPEAFMP 438

  Fly   441 FGFGRHRCMGDLLGRQNLFMFTTTVLQNFKMVAIPGQ-VPEEVPLEGATAAVKPYDIMLVAREQ 503
            |..||..|:|:.|.|..||:|.|.:||.|......|| .|....:.|...|..||.:..|.|:|
Mouse   439 FSAGRRSCLGEALARMELFLFFTCLLQRFSFSVPDGQPQPSNSGVYGILVAPSPYQLCAVVRDQ 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	137/469 (29%)
Cyp2d9	NP_034136.2	p450	37..496	CDD:278495	142/486 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820