DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp303a1 and Cyp2c29

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_031841.3	Gene:	Cyp2c29 / 13095	MGIID:	103238	Length:	490	Species:	Mus musculus

Alignment Length:	508	Identity:	141/508 - (27%)
Similarity:	247/508 - (48%)	Gaps:	36/508 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 YTVIWIFCATLLAILFGGVRKPKRFPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYVNP 67
            :..:.:.|..||::......:.| .||||...||:|:.||:.         .|.|......:...
Mouse     6 FLALTLSCLILLSLWRQSSGRGK-LPPGPTPLPIIGNFLQID---------VKNISQSFTNFSKA 60

  Fly    68 YG-FYGLKIGKDKVVIAYTNDAISEMMTN--EDIDGRPDGIFYRLRTFNSRLGVLLTDGEMWVEQ 129
            || .:.|.:|....||.:..:|:.|.:.:  |:..||  |.|..........||:.::|..|.|.
Mouse    61 YGPVFTLYLGSKPTVILHGYEAVKEALIDRGEEFAGR--GSFPMAEKIIKGFGVVFSNGNRWKEM 123

  Fly   130 RRFILRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVYVLNTLWCML 194
            |||.|..|:|.|..:..:.|.|..||.||:::|:..      |.:..:...:.|....|.:..::
Mouse   124 RRFTLMTLRNLGMGKRNIEDRVQEEAQCLVEELRKT------KGSPCDPTFILSCAPCNVICSII 182

  Fly   195 SGRRYEPGSPEITQLLETFFELFKNIDMVGA----LFSHFPLLRFIAPNFSGYNGFVESHRSLYT 255
            ...|::....|...|::   ::.:|:.::.:    :.:.||.|....|  ..::..|::...|.:
Mouse   183 FQNRFDYKDKEFLILMD---KINENVKILSSPWLQVCNSFPSLIDYCP--GSHHKIVKNFNYLKS 242

  Fly   256 FMSKEIELHRLTYKNYDEPRDLMDSYLRAQDEGND-EKGMFSDQSLLAICLDMFLAGSETTNKSL 319
            ::.::|:.|:.:. :...|||.:|.||..|.:.|. |:..||.::|.:...|:|.||:|||:.:|
Mouse   243 YLLEKIKEHKESL-DVTNPRDFIDYYLIKQKQVNHIEQSEFSLENLASTINDLFGAGTETTSTTL 306

  Fly   320 GFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFMLHTFGIPHRA 384
            .:..:.|:..|::..:..:||..|||..|.| ..:||:.:||.:|:..|..|...|....:||..
Mouse   307 RYALLLLLKYPDVTAKVQEEIDRVVGRHRSP-CMQDRSHMPYTDAMIHEVQRFIDLLPTSLPHAV 370

  Fly   385 VCDTRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYL-FDGHLKLPEAFNPFGFGRHRC 448
            .||.:...|.|||.|.||.....:|.:..:||:||.|:|..:| .:|:.|..:.|.||..|:..|
Mouse   371 TCDIKFRKYLIPKGTTVITSLSSVLHDSKEFPNPEMFDPGHFLNGNGNFKKSDYFMPFSTGKRIC 435

  Fly   449 MGDLLGRQNLFMFTTTVLQNFKMVAI--PGQVPEEVPLEGATAAVKPYDIMLV 499
            .|:.|.|..||:..||:|||||:.::  |.::.....:.|..:...||.:..:
Mouse   436 AGEGLARMELFLILTTILQNFKLKSLVHPKEIDITPVMNGFASLPPPYQLCFI 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	134/462 (29%)
Cyp2c29	NP_031841.3	p450	30..487	CDD:278495	137/480 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920