DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp303a1 and Cyp2b9

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	XP_011248733.1	Gene:	Cyp2b9 / 13094	MGIID:	88600	Length:	517	Species:	Mus musculus

Alignment Length:	503	Identity:	144/503 - (28%)
Similarity:	239/503 - (47%)	Gaps:	55/503 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 PGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYV-------------NPYG-FYGLKIGKDK 79
            ||..|..::.:.|    ||...|...:.:||..:|..             ..:| .:.:.:|...
Mouse    40 PGVGWIILMIAGL----LRKVYGAVEQTMDVRGKQNALVIQHAPLDQRLQEKHGDVFTVHLGPRP 100

  Fly    80 VVIAYTNDAISEMMTN--EDIDGRPDGIFYRLRTFNSRLGVLLTDGEMWVEQRRFILRHLKNFGF 142
            ||:......|.|.:.:  |...||  |.....:......|:....|:.|...|||.|..:|.||.
Mouse   101 VVVLCGTQTIREALVDHAEAFSGR--GTIAAAQLVMQDYGIFFASGQRWKTLRRFSLATMKEFGM 163

  Fly   143 ARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVY---VLNTLWCMLSGRRYEPGSP 204
            .:..:.:.:..||.||:::||        |...:.: |.|.::   ..|.:..::.|.|::....
Mouse   164 GKRSVEERIKEEAQCLVEELK--------KYQGVPL-DPTFLFQCITANIICSIVFGERFDYTDD 219

  Fly   205 EITQLLETFFELFKNIDMVGA----LFSHFPLLRFIAPNFSG-YNGFVESHRSLYTFMSKEIELH 264
            :...||...:::|..:.....    |||.|  |::    |.| :...|:..:.|..:::..:|.|
Mouse   220 QFLHLLNLMYKIFSLLSSFSGQMFELFSGF--LKY----FPGVHRQIVKKQQELLDYIAHSVEKH 278

  Fly   265 RLTYKNYDEPRDLMDSY-LRAQDEGNDEKGMFSDQSLLAICLDMFLAGSETTNKSLGFCFMHLVL 328
            :.|. :...|||.:|:| ||.:.|.::....|..|:|:...|.:|.||:|||:.:|.:..:.::.
Mouse   279 KATL-DPSAPRDYIDTYLLRMEKEKSNHNTEFHHQNLMMSVLSLFFAGTETTSATLHYGVLLMLK 342

  Fly   329 QPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFMLHTFGIPHRAVCDTRLSGY 393
            .|.:.|:..:||.:|:|..|:|... ||||:||.:|:..|..|...|...|:||:.:.||...||
Mouse   343 YPHVTEKVQKEIDQVIGSHRLPTLD-DRTKMPYTDAVIHEIQRFSDLVPIGLPHKVIKDTLFRGY 406

  Fly   394 EIPKDTMVIACFRGMLINPVDFPDPESFNPDRYL-FDGHLKLPEAFNPFGFGRHRCMGDLLGRQN 457
            .:||:|.|.......|.:|..|..|:.|||:.:| .:|.||..|||.||..|:..|:|:.:.|..
Mouse   407 LLPKNTEVYPVLSSALHDPQYFEQPDKFNPEHFLDANGALKKCEAFLPFSTGKRICLGESIARNE 471

  Fly   458 LFMFTTTVLQNFKMVAIPGQVPEEV---PLEGATAAVKP-YDIMLVAR 501
            ||:|.||:||||. ||.| ..|:::   |.|.....:.| :.|..:||
Mouse   472 LFIFFTTILQNFS-VASP-VAPKDIDLTPKESGIGKIPPAHQIYFLAR 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	137/476 (29%)
Cyp2b9	XP_011248733.1	p450	82..512	CDD:365848	131/450 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820