DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp303a1 and Cyp2b19

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_031840.1	Gene:	Cyp2b19 / 13090	MGIID:	107303	Length:	492	Species:	Mus musculus

Alignment Length:	516	Identity:	161/516 - (31%)
Similarity:	252/516 - (48%)	Gaps:	39/516 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFYTVIWIFCATLLAILF-GGVRKPK---RFPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFA 61
            |.::|:.:...|...::| ....:||   .|||||...|.:|:.||:.    |.|:....|
Mouse     1 MEFSVLLLLALTTGFLIFLVSQSQPKTHGHFPPGPRPLPFLGNLLQMD----RRGLLSSFI---- 57

  Fly    62 RQYVNPYG-FYGLKIGKDKVVIAYTNDAISEMMTN--EDIDGRPDGIFYRLRTFNSRLGVLLTDG 123
             |....|| .:.:.:|...||:....|.|.|.:.|  |...||  |....|.......||:.:.|
Mouse    58 -QLQEKYGDVFTVHLGPRPVVMLCGTDTIREALVNQAEAFSGR--GTVAVLDPIVQGYGVIFSSG 119

  Fly   124 EMWVEQRRFILRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVYVLN 188
            |.|...|||.|..:::||..:..:.:.:..||.||:::||    |..|.......:  ....|.|
Mouse   120 ERWKTLRRFSLATMRDFGMGKRSVEERIKEEAQCLVEELK----KYKGAPLNPTFY--FQCIVAN 178

  Fly   189 TLWCMLSGRRYEPGSPEITQLLETFFELFKNIDMVGALFSH-FPLLRFIAPNFSGYNGFVESH-R 251
            .:..::.|.|::....:...||...::.|   .::.:|.|. |.|...|...|.|.:..:..: :
Mouse   179 IICSIVFGERFDYKDHQFLHLLNLIYQTF---SLMSSLSSQVFELFSAILKYFPGAHRQISKNLQ 240

  Fly   252 SLYTFMSKEIELHRLTYKNYDEPRDLMDSY-LRAQDEGNDEKGMFSDQSLLAICLDMFLAGSETT 315
            .:..::...:|.||.|. :...|||.:|:| ||.:.|.::....|..|:|:...|.:|.||:|||
Mouse   241 EILDYIGHSVEKHRATL-DPSAPRDFIDTYLLRMEKEKSNHHTEFHHQNLVISVLSLFFAGTETT 304

  Fly   316 NKSLGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFMLHTFGI 380
            :.:|.:.|:.::..|.:.|:..:||.:|:|..|:|... ||||:||.:|:..|..|...|...|:
Mouse   305 STTLRYSFLIMLKYPHVAEKVQKEIDQVIGSHRLPTLD-DRTKMPYTDAVIHEIQRFTDLAPIGL 368

  Fly   381 PHRAVCDTRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYL-FDGHLKLPEAFNPFGFG 444
            ||:...||...||.|||:|.|.......|.:|..|..|:||||:.:| .:|.||..|||.||..|
Mouse   369 PHKVTKDTLFRGYLIPKNTEVYPILSSALHDPRYFEQPDSFNPEHFLDANGALKTNEAFMPFSTG 433

  Fly   445 RHRCMGDLLGRQNLFMFTTTVLQNFKMVAIPGQVPEEVPL----EGATAAVKPYDIMLVAR 501
            :..|:|:.:.|..||:|.||:||||.: |.| ..||.:.|    .|||.....|.|..::|
Mouse   434 KRICLGEGIARNELFLFFTTILQNFSL-ASP-VAPENIDLIPNNSGATKTPPQYQIHFLSR 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	145/458 (32%)
Cyp2b19	NP_031840.1	p450	32..487	CDD:278495	152/478 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.859108	Normalized mean entropy	S3475
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.770