DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp303a1 and Cyp2a5

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_031838.2	Gene:	Cyp2a5 / 13087	MGIID:	88597	Length:	494	Species:	Mus musculus

Alignment Length:	496	Identity:	135/496 - (27%)
Similarity:	236/496 - (47%)	Gaps:	53/496 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RFPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYVNPYG-FYGLKIGKDKVVIAYTNDAI 89
            :.||||...|.:|:.||::..:    |:..::.:..|     || .:.:.:|..::|:....:|:
Mouse    32 KLPPGPTPLPFIGNFLQLNTEQ----MYNSLMKISQR-----YGPVFTIYLGPRRIVVLCGQEAV 87

  Fly    90 SEMMTN--EDIDGRPDGIFYRLRTFN---SRLGVLLTDGEMWVEQRRFILRHLKNFGFARSGMMD 149
            .|.:.:  |:..||.:     ..||:   ...||..:.||...:.|||.:..|::||..:.|:.:
Mouse    88 KEALVDQAEEFSGRGE-----QATFDWLFKGYGVAFSSGERAKQLRRFSIATLRDFGVGKRGIEE 147

  Fly   150 IVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVYVLNTLWCMLSGRRYEPGSPEITQLLETFF 214
            .:..||..|:    |...|:.|  ..|:.....|..|.|.:..::.|.|::....|...||....
Mouse   148 RIQEEAGFLI----DSFRKTNG--AFIDPTFYLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMML 206

  Fly   215 ELF--------KNIDMVGALFSHFPLLRFIAPNFSGYNGFVESHRSLYTFMSKEIELHRLTYKNY 271
            ..|        :..:|..::..|.|     .|....:    :..:.|..|::|::| |.....:.
Mouse   207 GSFQFTATSMGQLYEMFSSVMKHLP-----GPQQQAF----KELQGLEDFITKKVE-HNQRTLDP 261

  Fly   272 DEPRDLMDSYL-RAQDEGNDEKGMFSDQSLLAICLDMFLAGSETTNKSLGFCFMHLVLQPEIQER 335
            :.|||.:||:| |..:|..:....|..::|:...|::|.||:||.:.:|.:.|:.|:..|:|:.:
Mouse   262 NSPRDFIDSFLIRMLEEKKNPNTEFYMKNLVLTTLNLFFAGTETVSTTLRYGFLLLMKHPDIEAK 326

  Fly   336 AFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFMLHTFGIPHRAVCDTRLSGYEIPKDTM 400
            ..:||..|:|..|.|:: .||.|:||.||:..|..|...:...|:..|...||:...:.:||.|.
Mouse   327 VHEEIDRVIGRNRQPKY-EDRMKMPYTEAVIHEIQRFADMIPMGLARRVTKDTKFRDFLLPKGTE 390

  Fly   401 VIACFRGMLINPVDFPDPESFNPDRYLFD-GHLKLPEAFNPFGFGRHRCMGDLLGRQNLFMFTTT 464
            |......:|.:|..|.:|:.|||..:|.| |..|..:||.||..|:..|.|:.|.|..||:|.|.
Mouse   391 VFPMLGSVLKDPKFFSNPKDFNPKHFLDDKGQFKKNDAFVPFSIGKRYCFGEGLARMELFLFLTN 455

  Fly   465 VLQNFKMVAIPGQVPEEV---PLEGATAAVKP-YDIMLVAR 501
            ::|||...:.  |.|:::   |.....|.:.| |.:..::|
Mouse   456 IMQNFHFKST--QAPQDIDVSPRLVGFATIPPTYTMSFLSR 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	129/467 (28%)
Cyp2a5	NP_031838.2	p450	34..491	CDD:278495	134/489 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820