DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp303a1 and CYP2R1

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_078790.2	Gene:	CYP2R1 / 120227	HGNCID:	20580	Length:	501	Species:	Homo sapiens

Alignment Length:	513	Identity:	140/513 - (27%)
Similarity:	234/513 - (45%)	Gaps:	52/513 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLAILFG-GV------RKPKRFPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYVNPYG- 69
            |..:||. ||      |:|..|||||...|.:|:...       |....::..|:.|:....||
Human    18 LFLLLFALGVRQLLKQRRPMGFPPGPPGLPFIGNIYS-------LAASSELPHVYMRKQSQVYGE 75

  Fly    70 FYGLKIGKDKVVIAYTNDAISEMMT--NEDIDGRPD-GIFYRLRTFNSRLGVLLTD--GEMWVEQ 129
            .:.|.:|....|:....|.:.|.:.  :|....||. .:|.::    :::|.||..  |..||:.
Human    76 IFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKM----TKMGGLLNSRYGRGWVDH 136

  Fly   130 RRFILRHLKNFGFARSGMMDIVHNEATCLLQDLK---DKVLKSGGKQTRIEMHDLTSVYVLNTLW 191
            ||..:...:.||:.:...       .:.:|::.|   |.:....|:.  .:...|.:..|.|...
Human   137 RRLAVNSFRYFGYGQKSF-------ESKILEETKFFNDAIETYKGRP--FDFKQLITNAVSNITN 192

  Fly   192 CMLSGRRYEPGSPEITQLLETFFELFKNIDMVGA----LFSHFPLLRFIAPNFSGYNGFVESHRS 252
            .::.|.|:.....:...::|.|.|   |:::..:    |::.||.:..:.  |..:.....:...
Human   193 LIIFGERFTYEDTDFQHMIELFSE---NVELAASASVFLYNAFPWIGILP--FGKHQQLFRNAAV 252

  Fly   253 LYTFMSKEIELHRLTYKNYDEPRDLMDSYLRAQDEG-NDEKGMFSDQSLLAICLDMFLAGSETTN 316
            :|.|:|:.||...:..|. ..|:..:|:||...|:| ||....||.::|:....::.:||:|||.
Human   253 VYDFLSRLIEKASVNRKP-QLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTT 316

  Fly   317 KSLGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFMLHTFGIP 381
            ..|.:..:.:.|.|.||.:..:||..::|....|.|. |:.|:||.||:..|.:|...:...||.
Human   317 NVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWD-DKCKMPYTEAVLHEVLRFCNIVPLGIF 380

  Fly   382 HRAVCDTRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYL-FDGHLKLPEAFNPFGFGR 445
            |....|..:.||.|||.|.||.....:..:...:.|||.|:|:|:| ..|:....||..||..||
Human   381 HATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGR 445

  Fly   446 HRCMGDLLGRQNLFMFTTTVLQNFKMVAIPGQVPEEVPLEGATAAVKPYDIMLVAREQ 503
            ..|:|:.|.|..:|:|.|.:||.|.:......||:..|..|.|...:||   |:..|:
Human   446 RHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQPQPY---LICAER 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	124/466 (27%)
CYP2R1	NP_078790.2	p450	57..497	CDD:278495	124/462 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920