DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp303a1 and cyp2aa7

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_001103192.1	Gene:	cyp2aa7 / 101882126	ZFINID:	ZDB-GENE-071004-48	Length:	499	Species:	Danio rerio

Alignment Length:	524	Identity:	142/524 - (27%)
Similarity:	238/524 - (45%)	Gaps:	73/524 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 IFCATLLAILFGGVR---KPKRFPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYVNPYG 69
            :|...:..:||...|   ...||||||...|.||:                    ......||..
Zfish    17 LFLGLIFLVLFEIFRINSYKGRFPPGPTPLPFVGN--------------------LPHSLKNPME 61

  Fly    70 F------YG----LKIGKDKVVIAYTNDAISEMMTNEDIDGRP---------DGIFYRLRTFNSR 115
            |      ||    :.:|:...::..|.....|....:...|||         :|:...:.|||
Zfish    62 FIRSMPQYGEMTTMYLGRRPAIVLNTIQLAKEAFVQDAFSGRPFLPVMDWVANGLGIIMVTFN-- 124

  Fly   116 LGVLLTDGEMWVEQRRFILRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHD 180
                    ..|.:||||.|..|:|||..:..:.|.|..|:..|:.:    :||..||.  :..|.
Zfish   125 --------HSWRQQRRFALHTLRNFGLGKKSVEDRVLEESRYLIAE----ILKGEGKP--MSPHH 175

  Fly   181 LTSVYVLNTLWCMLSGRRYEPGSPEITQLLETFFELF-KNIDMVGALFSHFPLLRFIAPNFSG-Y 243
            .....|.|.:..::.|.|::..:.....|||...|.| ......|.:|:..|.::    :|.| :
Zfish   176 PIQNAVSNIICSIVFGDRFDYDNKRFEYLLELLNENFVLTGSAAGQIFNLAPFIK----HFPGPH 236

  Fly   244 NGFVESHRSLYTFMSKEIELHRLTYKNYDEPRDLMDSY-LRAQDEGNDEKGMFSDQSLLAICLDM 307
            ....::...|..|:..|::.|:.|. :.|.|||.:|:| |..:.:.:::...|.:.:|.....|:
Zfish   237 QKIKQNANELLAFIQGEVKEHKKTL-DPDSPRDFIDAYLLEIEKQKSNKDSTFHEGNLAISTADL 300

  Fly   308 FLAGSETTNKSLGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRM 372
            ||||::||:.::.:..:.|...|::|||..:||.:|:|.:|:|... ||.||||..|...|..|.
Zfish   301 FLAGTDTTSTTIRWGLLFLTQNPDVQERCHEEIVQVLGYDRLPSMD-DRDKLPYTLATVHEIQRC 364

  Fly   373 FMLHTFGIPHRAVCDTRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYLFDG-HLKLPE 436
            ..|..||:.|..:..|:|.||:||:.|:|:.....:|.:...:..|::|||:.:|.:. ....||
Zfish   365 ANLVPFGVIHETIQPTKLRGYDIPQGTVVMTNLAAILSDKEHWKHPDTFNPENFLDENRQFSKPE 429

  Fly   437 AFNPFGFGRHRCMGDLLGRQNLFMFTTTVLQNFKMVAIPGQVPEEVPLEGATAAVK---PYDIML 498
            :|.||..|...|:|:.|.:..||:|.|::||.....:.|...|  :.::|....|:   |:.|:.
Zfish   430 SFIPFSLGLRFCLGETLAKMELFLFITSLLQRIHFSSPPDAKP--IDMDGVVGIVRYPQPFSIIC 492

  Fly   499 VARE 502
            .:|:
Zfish   493 CSRD 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	130/474 (27%)
cyp2aa7	NP_001103192.1	p450	40..491	CDD:278495	134/494 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.910