DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp303a1 and Cyp2c69

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_001097995.1	Gene:	Cyp2c69 / 100043108	MGIID:	3721049	Length:	491	Species:	Mus musculus

Alignment Length:	476	Identity:	127/476 - (26%)
Similarity:	221/476 - (46%)	Gaps:	31/476 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VIWIFCATLLAIL-FGGVRKPKR-FPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYVNP 67
            |:.:.|.:.:.:| ....|..:| .||||...||:|:...:..         |.|......:...
Mouse     5 VVLVLCLSFMLLLSLWRQRSARRNLPPGPTPLPIIGNYHLIDM---------KDIGQCLTNFSKT 60

  Fly    68 YG-FYGLKIGKDKVVIAYTNDAISEMMTN--EDIDGRPDGIFYRLRTFNSRLGVLLTDGEMWVEQ 129
            || .:.|..|...:|:.:..:||.|.:.:  |...||  |.|......:...|:..:.|.:|...
Mouse    61 YGPVFTLYFGSQPIVVLHGYEAIKEALIDHGEVFSGR--GSFPFFDKVSKGKGIGFSHGNVWKAT 123

  Fly   130 RRFILRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVYVLNTLWCML 194
            |.|.:..|:|....:..:.:.|..||..|:::||    |:.|  :..:...:......|.:..::
Mouse   124 RVFTVNTLRNLAMGKRTIENKVQEEAQWLMKELK----KTNG--SPCDPQFIIGCAPCNVICSIV 182

  Fly   195 SGRRYEPGSPEITQLLETFFELFKNIDMVGA-LFSHFPLLRFIAPNFSGYNGFVESHRSLYTFMS 258
            ...|::....:...|:....|..:.:...|. :|:..|:|....|  ..:|.|.::|..:.:::.
Mouse   183 FQNRFDYKDKDFLSLIGKVNECTEILSSPGCQIFNAVPILIDYCP--GRHNKFFKNHTWIKSYLL 245

  Fly   259 KEIELHRLTYKNYDEPRDLMDSYL--RAQDEGNDEKGMFSDQSLLAICLDMFLAGSETTNKSLGF 321
            ::|:.|..:. :...|||.:|.:|  |.||:| .|...::.:.|..:..|:...|:||.:.::.|
Mouse   246 EKIKEHEESL-DVTNPRDFIDYFLIQRRQDKG-IEHMEYTIEHLATLVTDLVFGGTETLSSTMRF 308

  Fly   322 CFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFMLHTFGIPHRAVC 386
            ..:.|:....|..:..:||..|:|..|.| ..:||..:||..|:..|..|...|....:.|...|
Mouse   309 ALLLLMKHTHITAKVQEEIDNVIGRHRSP-CMQDRKHMPYTNAMVHEVQRYVDLGPTSLVHEVTC 372

  Fly   387 DTRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYLFD-GHLKLPEAFNPFGFGRHRCMG 450
            ||:...|.|||.|.|:.....:|.:..:||:||.|:|..:|.| |:.|..:.|.||..|:..|:|
Mouse   373 DTKFRNYFIPKGTQVMTSLSSVLHDSTEFPNPEVFDPGHFLDDNGNFKKSDYFVPFSAGKRICVG 437

  Fly   451 DLLGRQNLFMFTTTVLQNFKM 471
            :.|.|..||:|.||:|||||:
Mouse   438 ESLARMELFLFLTTILQNFKL 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	122/451 (27%)
Cyp2c69	NP_001097995.1	p450	30..487	CDD:278495	122/451 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010