DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NTRK3 and trk-1

DIOPT Version :9

Sequence 1:	XP_016877743.1	Gene:	NTRK3 / 4916	HGNCID:	8033	Length:	850	Species:	Homo sapiens
Sequence 2:	NP_001360632.1	Gene:	trk-1 / 183575	WormBaseID:	WBGene00017039	Length:	842	Species:	Caenorhabditis elegans

Alignment Length:	903	Identity:	221/903 - (24%)
Similarity:	352/903 - (38%)	Gaps:	260/903 - (28%)

- Green bases have known domain annotations that are detailed below.

Human    17 LLGSVWLDYVGSVLACPANCV-CSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNI 80
            ||..:.|.|...||.. :.|| .::..:.|              .|..:.||.|.:.:.....::
Worm     6 LLTLLILTYSPGVLTI-SQCVKATRDTVRC--------------DDFIDFNGTAKVLVVGNCSSL 55

Human    81 TSI-HIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAK-NPHLRYINLSSNRLTTLS 143
            .:| .:..:...|::..|..:...             :..|..||. .|::|:|:::...||:|.
Worm    56 QNIDEMLGFGPFHSVTNVTFDCVV-------------THFPWEFANIFPNIRHIHINKCNLTSLP 107

Human   144 WQLFQTLSLRELQLEQNFFNCSCDIRWM---QLWQEQGEAKLNSQNLYCINADGSQLPLFRMNIS 205
            ||...|.:|:.:........|||..:||   :::::..|.|  |......|.|..:: :|
Worm   108 WQSIWTETLKTVDFSSCPIQCSCQNQWMRAKEIFEKITEPK--SLRKCAWNCDPGKM-MF----- 164

Human   206 QCDLPEISVSHVNLTVREGDNAVITCNGSGSPL------PDVDWIVTGLQSINTHQTNLNWTNVH 264
                |.:..|      :.|||..:........|      |..||..    |.:.|:        |
Worm   165 ----PGVIYS------KNGDNVTVHVGFDDQVLNRTIDKPYFDWAF----SKHPHK--------H 207

Human   265 -------AINLTLVNVTSEDNGFTLTCIAENVVGMS--------NASVALTVYYPPRVVSLEEPE 314
                   ..:|.:.|:..||.|         |:|:.        ...:.|...||.:|..:::..
Worm   208 EEIIAEKGADLMITNLKREDMG---------VIGVKCWHCLDFLVGKIELRANYPVKVAFVDKTR 263

Human   315 LRLEHCIEFVVRGNPPPTL---------HWLHNGQPLRE-------SKIIHVE----YYQ----- 354
            |..:.   .||.|.|...:         ::.......||       |.::.:|    :||
Worm   264 LDTDF---LVVTGYPIDNISMAITKMQSNYSETNFVGREKDAIFFSSLVVRMEKRPLFYQKTYRV 325

Human   355 ------EGEISEGCLLFNKPTHYNNGNYTLIAK--NPLGTANQTINGHFLKEPFPESTDNFILFD 411
                  ||:...|.|.|...|   ||:...|.|  :.||..|.||             |:||:
Worm   326 FTKDAAEGDHLSGDLRFEVCT---NGSCDAIEKHVSHLGLINGTI-------------DDFII-- 372

Human   412 EVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGR--------------RSKF 462
                   :...:|.|     :.|.|.|... |:|:||..:..  |.|              |.:.
Worm   373 -------VEYPYKQE-----IQIVVFLIVI-CLLIVVSALAF--YHRLKLQSFLREKILSFRKRI 422

Human   463 GMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPD 527
            .:...:......:::...|..:....:..|.        ...|| :|.|:
Worm   423 SLAQELQTRRASQETEETLLRLEERSSLASD--------YTNMT-LPFID--------------- 463

Human   528 TYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELL 592
                   ..:|.:...||:|.||:|:||......|..    ||||:::...:|..|    ||.:|
Worm   464 -------MGNIEIHEMLGKGHFGEVYLASWDYTGPRS----VAVKSIRRVDMATEK----EARVL 513

Human   593 TNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQML 657
            .:|:|.:|||.||:..:...|::|||:|.||||..:|....|...:.:...|     .|.:.::.
Worm   514 QDLEHPNIVKLYGMTRNNFNLLLVFEHMNHGDLKTYLEQRAPVKSVYLQYPP-----PLVIDELK 573

Human   658 HIASQIASGMVYLASQHFVHRDLATRNCLVGAN-------------LLVKIGDFGMSRDVYS-TD 708
            .|..:|.:|:|||..|..||||||.|||||..:             :.|||.||||||.:|. ::
Worm   574 WIIKEITTGLVYLVEQSIVHRDLAARNCLVAGDSDLKATSHFERPPIRVKISDFGMSRRLYDHSE 638

Human   709 YYREGPCQKGPFSVVWQRQRLAATAASTVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWE 773
            ||                         |:.....||:||:|||::...|||..||:||.||.:||
Worm   639 YY-------------------------TMDHRGALPVRWLPPEAVQSHKFTYNSDIWSLGVTMWE 678

Human   774 IFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEI 831
            ..:||:||:..|||.||......|....:|..||:::||:|:.||..||.:|:..|:|
Worm   679 CMSYGRQPFDGLSNLEVSSFTLAGMRPLKPERCPQDMYDLMVKCWHMEPVKRITAKQI 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NTRK3	XP_016877743.1	LRR_8	103..160	CDD:290566	13/57 (23%)
		leucine-rich repeat	105..128	CDD:275378	3/23 (13%)
		leucine-rich repeat	129..151	CDD:275378	8/21 (38%)
		leucine-rich repeat	152..164	CDD:275378	1/11 (9%)
		TPKR_C2	163..208	CDD:293525	11/47 (23%)
		Ig_TrkABC_d4	211..301	CDD:143173	19/110 (17%)
		IG_like	218..301	CDD:214653	18/103 (17%)
		Ig_TrKABC_d5	319..396	CDD:143172	25/109 (23%)
		PTKc_TrkC	532..843	CDD:270676	111/314 (35%)
		TyrKc	538..835	CDD:197581	111/308 (36%)
trk-1	NP_001360632.1	PTKc	471..738	CDD:270623	110/304 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910