DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NTRK3 and sid-3

DIOPT Version :9

Sequence 1:	XP_016877743.1	Gene:	NTRK3 / 4916	HGNCID:	8033	Length:	850	Species:	Homo sapiens
Sequence 2:	NP_510783.2	Gene:	sid-3 / 181756	WormBaseID:	WBGene00002207	Length:	1237	Species:	Caenorhabditis elegans

Alignment Length:	383	Identity:	114/383 - (29%)
Similarity:	173/383 - (45%)	Gaps:	70/383 - (18%)

- Green bases have known domain annotations that are detailed below.

Human   483 HINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKP-DTYVQH-------------- 532
            |.:| :.....|:.|...|.|...|..::   :..|:..|...| ..|:|.
Worm    40 HFSH-VRDKDMLEIGMQQVQIRQLREQIL---KMSREMWNRSDPKQVYIQADQSMPAQNSIDEKA 100

Human   533 -IKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQ 596
             |....|.|...:|||:|..|........:.|  .:.||||.|:|.:.....|.:.||..|..||
Worm   101 LIPNEQIKLYELIGEGSFAVVKRGTWTQSNGT--HVNVAVKILRDISPNIMDDLRVEASHLLKLQ 163

Human   597 HEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIAS 661
            |..:::.||:.  ..|.:||||..:.|.|...|| ....|::||             |::.....
Worm   164 HPSLIRLYGIV--RQPAMMVFELCEGGSLLDRLR-DDKKAILLV-------------SRLHDYCM 212

Human   662 QIASGMVYLASQHFVHRDLATRNCLVGAN-LLVKIGDFGMSRDVYSTD-YYREGPCQKGPFSVVW 724
            |||..:.:|.|:|.||||:|.||.|:..: ..|||.|||:.|.:...: .|...|.:|.||:
Worm   213 QIAKALQFLESKHCVHRDVAARNILLARDERTVKICDFGLMRALKENEQMYTMAPQKKVPFA--- 274

Human   725 QRQRLAATAASTVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTE 789
                                  |.|||::.:|||:..|||||:||.:||:||:|::||......:
Worm   275 ----------------------WCPPEALRHRKFSHASDVWSYGVTIWEVFTFGEEPWVGCRAID 317

Human   790 VIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLD 847
            |::.|..|..||:|:.|.:.:|.:|..||:..|.:|.....|.:.|.|     .::||
Worm   318 VLKNIDAGERLEKPKYCSERIYQIMKNCWKFNPAERCKFGAIREDLVA-----AMFLD 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NTRK3	XP_016877743.1	LRR_8	103..160	CDD:290566
		leucine-rich repeat	105..128	CDD:275378
		leucine-rich repeat	129..151	CDD:275378
		leucine-rich repeat	152..164	CDD:275378
		TPKR_C2	163..208	CDD:293525
		Ig_TrkABC_d4	211..301	CDD:143173
		IG_like	218..301	CDD:214653
		Ig_TrKABC_d5	319..396	CDD:143172
		PTKc_TrkC	532..843	CDD:270676	100/327 (31%)
		TyrKc	538..835	CDD:197581	97/298 (33%)
sid-3	NP_510783.2	SAM_TNK-like	9..70	CDD:188938	7/33 (21%)
		STYKc	107..363	CDD:214568	97/298 (33%)
		PTKc_Ack_like	111..365	CDD:270636	96/296 (32%)
		SH3	371..421	CDD:214620	114/383 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910