DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NTRK3 and ver-3

DIOPT Version :9

Sequence 1:	XP_016877743.1	Gene:	NTRK3 / 4916	HGNCID:	8033	Length:	850	Species:	Homo sapiens
Sequence 2:	NP_509836.1	Gene:	ver-3 / 181289	WormBaseID:	WBGene00006896	Length:	1227	Species:	Caenorhabditis elegans

Alignment Length:	895	Identity:	208/895 - (23%)
Similarity:	337/895 - (37%)	Gaps:	239/895 - (26%)

- Green bases have known domain annotations that are detailed below.

Human    39 SKTEINCRRPDDGNLFPLLEGQDSGNS--NGNASINITDISRNITSIHIENWRSLHTLNAVDMEL 101
            |:|.||    ||   |..:.....|:.  :.|..|....:|.|::..::.:...:.|:..|..|:
Worm   390 SETIIN----DD---FRKIAATSFGDGAFSENLDIKAFAVSTNMSGTYVLSISHMDTVQVVQWEV 447

Human   102 YTGLQ------KLTIKNSGLRSIQPRAFAK---NPHLRYINLS---------------------- 135
              .::      ::|::......|..:.:.|   |.|:..|::|
Worm   448 --AIENDEPDVQITVREPSSFFISNQEYYKPDTNLHIECISISIPPADVVFEYKTKNSEQFQEIE 510

Human   136 SNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLF 200
            .|:|.::.....:.|.......|.....|| .||       :|...:....|..| .:|.::...
Worm   511 PNKLVSVGGTFDRGLIYNVTFTEGMDLKCS-SIR-------KGNRAITVNKLIKI-GEGFEVRPH 566

Human   201 RMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIV---------TGLQSI-NTHQ 255
            ....|:.     :.|..:..:.||||..:||   ..||...||.|         :.:.|| .|.:
Worm   567 HEKSSKA-----TESEPSKIIYEGDNVKLTC---VFPLDSDDWSVSWRFENSKSSDISSIPTTTE 623

Human   256 TNLNWTNVHAINLTLVNVTSEDNGFTLTCIAEN---------------------VVGMSNASVAL 299
            |.:...:.|.| |.|.:||:...| |.||:.:|                     ..|.|||.|.:
Worm   624 TEIKQYSKHLI-LNLRDVTTSFTG-TYTCVVKNEDSEKLLETSIDVKAISKPSITGGNSNAVVIV 686

Human   300 TV--YYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGC 362
            ..  |:.                |...:.|.|||...|..:|.|           |..|::....
Worm   687 DYDQYFE----------------INCNMTGTPPPVYQWFKDGNP-----------YTHGDVDGSI 724

Human   363 LLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEE 427
            |..::....::|.:..:|.|..|....:|.                          :.|.:.|:.
Worm   725 LRVSRARGEDDGEFHCLATNRAGDKLNSIE--------------------------VQVNNAPKG 763

Human   428 DTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPS 492
            ..|....   ||....:.::.:|::..|....::         ::.::|.|     :|....|..
Worm   764 SLFFYWF---LALLLLISIIAVFLLTCKLRASNR---------LTKQKDIA-----LNTLYETMI 811

Human   493 SLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFG---KVFL 554
            ...|||  :...|..:|| |...|:...:|.::.|..       ::.:...:|.|.||   |..|
Worm   812 KHQAGP--LPEEMKDLPV-EERTYYLPYNNDYEIDPV-------NLEILNPIGSGHFGVVKKGLL 866

Human   555 AECYNLS--PTKDKMLVAVKALKDP-TLAARKDFQREAELLTNL-QHEHIVKFYGVCGDG---DP 612
            ...|..|  .:|.::.||||:..:| .:..:|....|.:::..: ::.:::...|.....   ..
Worm   867 GMAYPKSKIESKTRLPVAVKSSTNPFNVELQKMMAEELKVMCAIPKNPNVLALIGAVTKNMRQGQ 931

Human   613 LIMVFEYMKHGDLNKFLRAHG--------PDAMILVDGQ---PRQAK----------GE------ 650
            |.:|.|::..|:|.:||:||.        .|..:.||..   |...|          ||
Worm   932 LYIVTEFIDGGNLREFLQAHRNTFINELVEDEHVPVDDSYLVPNSVKKKIYKFDEKLGEGTRLLV 996

Human   651 -----LGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYY 710
                 |..|.:|.|..|||.||.:||....||||||.||.|:....:|:|.|||:|:...:..||
Worm   997 EDPDALCTSDLLSIGLQIAKGMAWLADVPCVHRDLACRNVLITKTKIVRIADFGLSKKHTNKTYY 1061

Human   711 REGPCQKGPFSVVWQRQRLAATAASTVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIF 775
            |....:..|                       ||:||||.|.|...|||.:|||||||:.|:|||
Worm  1062 RTKKSKDTP-----------------------LPVRWMPLECIEEFKFTQKSDVWSFGICLYEIF 1103

Human   776 TYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQR 825
            |.|..|:.......|||.|..|...::|..|..|:|::|..|||..|:.|
Worm  1104 TLGGTPYPNCDTFNVIEFIRNGNRNKQPEYCHDEIYELMKVCWQFNPKDR 1153

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NTRK3	XP_016877743.1	LRR_8	103..160	CDD:290566	11/87 (13%)
		leucine-rich repeat	105..128	CDD:275378	4/31 (13%)
		leucine-rich repeat	129..151	CDD:275378	4/43 (9%)
		leucine-rich repeat	152..164	CDD:275378	1/11 (9%)
		TPKR_C2	163..208	CDD:293525	9/44 (20%)
		Ig_TrkABC_d4	211..301	CDD:143173	32/120 (27%)
		IG_like	218..301	CDD:214653	31/113 (27%)
		Ig_TrKABC_d5	319..396	CDD:143172	16/76 (21%)
		PTKc_TrkC	532..843	CDD:270676	103/336 (31%)
		TyrKc	538..835	CDD:197581	103/330 (31%)
ver-3	NP_509836.1	IG	242..>313	CDD:214652
		IG_like	578..667	CDD:214653	26/93 (28%)
		Ig_3	578..654	CDD:290638	25/80 (31%)
		I-set	673..757	CDD:254352	22/136 (16%)
		IGc2	692..747	CDD:197706	14/81 (17%)
		STYKc	847..1163	CDD:214568	103/330 (31%)
		PTKc	851..1164	CDD:270623	103/326 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910