DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NTRK3 and F09G2.1

DIOPT Version :9

Sequence 1:	XP_016877743.1	Gene:	NTRK3 / 4916	HGNCID:	8033	Length:	850	Species:	Homo sapiens
Sequence 2:	NP_001343836.1	Gene:	F09G2.1 / 179108	WormBaseID:	WBGene00017310	Length:	994	Species:	Caenorhabditis elegans

Alignment Length:	947	Identity:	196/947 - (20%)
Similarity:	328/947 - (34%)	Gaps:	338/947 - (35%)

- Green bases have known domain annotations that are detailed below.

Human    28 SVLACPANCVCSKTEINCR----RPDDGNLFPLLEGQDSGNSNGNASINITDISR---------- 78
            :|...|:.|..:...:|.|    :.||  :.|:   |.|.|....:.:.|.|:.|
Worm   120 TVCCSPSQCKTAFGFMNYRDYVGKYDD--MEPV---QPSTNQYNFSFVLINDLKRVGSPQSACLY 179

Human    79 -----------NITSIHIENWRSLHTLNAVDME--LYTGLQKLTIKNSGLRSIQPRAFAKNPHLR 130
                       |||.         .||...::.  |.||....||...|...|.
Worm   180 NNYVLITNRLFNITD---------QTLVLAEIAKILRTGCITFTIIAVGNSEID----------- 224

Human   131 YINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCI---NA 192
                     |.:.:.:::|::|....::.  |||      :.:.::            ||   ..
Worm   225 ---------TKMMYDVYKTVTLNTYVVQS--FNC------LDILKD------------CIKPCGT 260

Human   193 DGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDV------DWIVTGLQSI 251
            .||| ..:.:.:..|..|         |..|   ...|...:.:|.|.:      ||.:|.|
Worm   261 GGSQ-QCYDVTLDVCATP---------TTAE---PTTTVTSTSTPKPTLDPEYLNDWQITYL--- 309

Human   252 NTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELR 316
                            ..:.|.||::.                        :...|..:.:|
Worm   310 ----------------FAITNRTSQEQ------------------------FSRLVKYISDP--- 331

Human   317 LEHC------IEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGN 375
            ||.|      |.|:.|.|  ....|:.:...:       ..|.|:....|..:.        :.|
Worm   332 LEDCSGKAMIIRFLARNN--SNSGWISDVDQV-------APYLQQLSYDEVLIA--------SDN 379

Human   376 YTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAA 440
            .||:.    |..|.|.:               ::::.||.:|...     |:.|..|...|.|..
Worm   380 RTLLP----GNDNVTFD---------------LVWEAVSTSPCYN-----EDGTVHVPKVVLLTD 420

Human   441 FACVLLV-----VLFVMINKY-------------GRRSKFGMKGPVAVISGEEDSASPLHHINHG 487
            |...:.|     .|..::..|             |.:||..||  ...|:.:|         .:|
Worm   421 FVSNVFVAQYNTTLLPLLEFYEFSIIAFTEEAYDGYKSKLAMK--AFQITNDE---------GYG 474

Human   488 ITTPSSL--DAGPDT-----VVIG--------MTRIPVIENPQY--------FRQGHNCHKPDTY 529
            .|....|  ..|.:.     ::||        :..:.|:...:|        |:..|
Worm   475 DTNELKLCPKQGSNVTTIMFIIIGTCSGAMLILILLTVLYRQKYMWMRKLKRFKTSH-------- 531

Human   530 VQHIKRRDI-----------VLKRE-LGEGAFGKVFLAECYNLSPTKDKML-----------VAV 571
            |..|...||           |:|.| ||.||:|.||..:...:.|..:|..           .||
Worm   532 VADIDDNDIFDHWELSWDKLVVKNEKLGHGAYGHVFKGKIVGVPPAIEKYNRAEALDYTDCDCAV 596

Human   572 KAL-KDPTLAARKDFQREAELLTNLQ-HEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGP 634
            |.| |..|.||:::|:.|.||:.||. :||:|...|.........:|.|:..|.||.::::....
Worm   597 KMLPKYATDAAKQEFRHEIELMKNLGFNEHLVNMLGCITVSAKSCLVLEHCCHRDLLRYVKNKKC 661

Human   635 DAMI------LVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANL-- 691
            |..|      .:|..          .:.|:.|.||..||.:|..:..:|||||.||.|:....
Worm   662 DLEISRSVDDTIDSH----------KEFLNFAWQITQGMRFLVDKRIIHRDLAARNILITEQCGM 716

Human   692 -LVKIGDFGMSRDVYSTDYYREGPCQKGPFSVVWQRQRLAATAASTVGGHTMLPIRWMPPESIMY 755
             ..|:.|||::  :.|.      |.:.|                 .|.|...|||:|:..|.:..
Worm   717 KSAKVSDFGLA--ILSE------PSENG-----------------EVTGSDRLPIKWLALECLEK 756

Human   756 RKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQR 820
            .:|:.:|||||||::::|:::.|..|:.::..||:|..:..|...:.|.:...::.::|..||..
Worm   757 AEFSFKSDVWSFGIVIFEMYSLGDVPFAEIEPTELIAHLKSGARPKFPLLATDKIEEIMSSCWSE 821

Human   821 EPQQRLNIKEIYKILHALGKATPI--------YLDIL 849
            :.::|.:..|:.|:.     ||.:        ||:::
Worm   822 KSEERPDFDELSKLF-----ATQLEQTTEGYGYLELI 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NTRK3	XP_016877743.1	LRR_8	103..160	CDD:290566	9/56 (16%)
		leucine-rich repeat	105..128	CDD:275378	4/22 (18%)
		leucine-rich repeat	129..151	CDD:275378	2/21 (10%)
		leucine-rich repeat	152..164	CDD:275378	2/11 (18%)
		TPKR_C2	163..208	CDD:293525	7/47 (15%)
		Ig_TrkABC_d4	211..301	CDD:143173	12/95 (13%)
		IG_like	218..301	CDD:214653	12/88 (14%)
		Ig_TrKABC_d5	319..396	CDD:143172	15/82 (18%)
		PTKc_TrkC	532..843	CDD:270676	93/344 (27%)
		TyrKc	538..835	CDD:197581	90/330 (27%)
F09G2.1	NP_001343836.1	PTKc	556..837	CDD:270623	87/320 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910