DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NTRK3 and scd-2

DIOPT Version :9

Sequence 1:	XP_016877743.1	Gene:	NTRK3 / 4916	HGNCID:	8033	Length:	850	Species:	Homo sapiens
Sequence 2:	NP_504685.3	Gene:	scd-2 / 179054	WormBaseID:	WBGene00004740	Length:	1421	Species:	Caenorhabditis elegans

Alignment Length:	962	Identity:	213/962 - (22%)
Similarity:	344/962 - (35%)	Gaps:	279/962 - (29%)

- Green bases have known domain annotations that are detailed below.

Human     5 LCPAKCS-FWRIFLL---------GSVWLDYVGSVLACPANCVCSKTEINCRRPDDG-------- 51
            ||....| .|:|.::         |...:...|..|....||...:..:|..|.:.|
Worm   455 LCSRTYSKVWQISVISKGINPMESGRTIIYEAGYTLIPKENCTWERVFVNIPRQNAGFRIGIFVT 519

Human    52 NLFPLLEGQDSGNSNGNASINITDISRNITSIHIENW----RSLHTLNAVDME------------ 100
            |.||   |.:...:..|.|.:.|...|:|..   ..|    ..::|..|...|
Worm   520 NYFP---GSEEYVAIDNLSFSPTCFERDINQ---STWDIPDLFINTCGASGFEQPQNCDHNRELD 578

Human   101 -------LYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLE 158
                   ...|.|:.|:..:|...::........:.: .:..:....||...|.:.||||
Worm   579 GQTGHFLKEDGTQQWTVPVTGFYRMEICGAGGGSNSK-ASGDTGDCVTLQVHLIENLSLR----- 637

Human   159 QNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVN----- 218
                         .|..:.||:.       |......:|     ..|.|.  :||.::|.
Worm   638 -------------MLIGQMGESP-------CFTEHDDEL-----RPSSCS--KISHNYVYDGKRG 675

Human   219 --------LTVREGDNAVITCNGSGSPLPDVDWIV-TGLQSINTHQTNLNWTNVHAINLTLVNVT 274
                    |||.:....|:...|:|:.....|..| .|..:|:............|::.|...|.
Worm   676 AAGGGATLLTVEKDLWNVVAGGGAGASWDGFDMEVGYGASAIHVKPDQRCNETCKAVSHTDFIVE 740

Human   275 SEDNGFTLTCIAE--------------NVVGM-----------------------SNASVALT-- 300
            ..||    .|..|              |..||                       ||.|:..:
Worm   741 RRDN----RCPGEKGESTVFGGFGGGGNSCGMLGGSGAGYQAGNPFGKSRARSGSSNVSIDFSKS 801

Human   301 -VYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQE--------- 355
             :||...  .|:|..:::..|.:   |..||....:             ..:|::|
Worm   802 PIYYQSE--RLDEGYIKIAFCRK---RCEPPTVCRF-------------RKDYFEEEYCGCPDGS 848

Human   356 --GEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPP 418
              .:..|.|.            :.|:.  |..:.||..|  |..|||....:...::|..:.|
Worm   849 NVTDTEEACA------------FPLVC--PSSSTNQYRN--FTYEPFCLCNNGKEIYDVYNDT-- 895

Human   419 ITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHH 483
                  .||........:....||.:.::....::..|..|.| .||..:..::..:........
Worm   896 ------CEEIQIWTLYNITFLIFAALTIIGALFVVYHYRNREK-QMKQEILDLTQMKSPDYLYDD 953

Human   484 INHGITT-PSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEG 547
            |..|.|| .::||:.|.                                 |.|..|...|.||.|
Worm   954 IYFGRTTRKAALDSLPS---------------------------------ISRDSIERGRVLGRG 985

Human   548 AFGKVFLAECYNLSPTKDKMLVAVKALK---DPTLAARKDFQREAELLTNLQHEHIVKFYGVCGD 609
            .||:|:..|...:.       :|||.:.   ..:.|::.||..||..:.....|::|:..|:..:
Worm   986 NFGEVYYGEYSGVK-------LAVKMISRTFSASQASQSDFCNEALCMGTFVDENVVRLIGIDFE 1043

Human   610 GDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQH 674
            ..|.::..|||:.|||..|::...|:.:.|   .|.|    |.:|.::.|...:|:|...|.:..
Worm  1044 KVPYMIALEYMEGGDLLSFVKECRPNQVSL---NPFQ----LAMSDLIKICCDVAAGCKCLETFG 1101

Human   675 FVHRDLATRNCLV---GANLLVKIGDFGMSRDV-YSTDYYREGPCQKGPFSVVWQRQRLAATAAS 735
            :||||:|.||.|:   |...:.||.||||:::: |.|:|||
Worm  1102 YVHRDIAARNILLTTRGPQRVAKIADFGMAKEITYGTEYYR------------------------ 1142

Human   736 TVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVL 800
             :.|.||:||:|.|||:.:...|||:||:|||||:.||:|:.|..|:....|.||:..:|:|..|
Worm  1143 -INGRTMMPIKWTPPEAFIDGVFTTKSDIWSFGVLCWEVFSLGVVPYPNRRNEEVMLMLTEGARL 1206

Human   801 ERPRVCPKEVYDVMLGCWQREPQQR---LNIKEIYKILH----ALGKATPIY 845
            |.|...|..||.:|..||:.....|   :::.||::.:.    ::|...||:
Worm  1207 EYPYGIPTRVYQLMRDCWKTAAADRPKFVDVVEIFQDIQDDPASVGMPFPIH 1258

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NTRK3	XP_016877743.1	LRR_8	103..160	CDD:290566	11/56 (20%)
		leucine-rich repeat	105..128	CDD:275378	3/22 (14%)
		leucine-rich repeat	129..151	CDD:275378	3/21 (14%)
		leucine-rich repeat	152..164	CDD:275378	2/11 (18%)
		TPKR_C2	163..208	CDD:293525	6/44 (14%)
		Ig_TrkABC_d4	211..301	CDD:143173	26/143 (18%)
		IG_like	218..301	CDD:214653	23/136 (17%)
		Ig_TrKABC_d5	319..396	CDD:143172	13/87 (15%)
		PTKc_TrkC	532..843	CDD:270676	102/324 (31%)
		TyrKc	538..835	CDD:197581	99/306 (32%)
scd-2	NP_504685.3	LDLa	305..338	CDD:238060
		Gly_rich	590..805	CDD:289573	43/251 (17%)
		PKc_like	969..1239	CDD:304357	100/341 (29%)
		TyrKc	976..1241	CDD:197581	98/303 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910