DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NTRK3 and hir-1

DIOPT Version :9

Sequence 1:	XP_016877743.1	Gene:	NTRK3 / 4916	HGNCID:	8033	Length:	850	Species:	Homo sapiens
Sequence 2:	NP_504458.1	Gene:	hir-1 / 178936	WormBaseID:	WBGene00016059	Length:	903	Species:	Caenorhabditis elegans

Alignment Length:	968	Identity:	222/968 - (22%)
Similarity:	360/968 - (37%)	Gaps:	319/968 - (32%)

- Green bases have known domain annotations that are detailed below.

Human    27 GSVLACPANCVC--SKTEI----------NCRRPDDGNLFPLLEGQDSGNS-----NGN------ 68
            |..|.|.|.||.  .|::.          .|::.::.||.       |.|:     ||.
Worm    26 GCFLRCVAQCVAFVEKSDSTQQSLDACKPQCQKLNNKNLC-------SDNTCWSTCNGELVPEKT 83

Human    69 --ASINITDISRNITSIHIENWRSL----------HTLNAVDMELYTG-----LQKLTIKNSGLR 116
              |..|:|     :..:...:|..:          .|||:   :.:|.     .:|.|:..|.|.
Worm    84 LPAPTNLT-----LKGVRGLSWSPVPGAVMYYIGYRTLNS---KTFTSDDFVITEKQTVDLSTLT 140

Human   117 SIQP--------RAFAKN---PHLRYINLSSNRLTTLSWQLFQTLSLRELQ-----LEQNFFNCS 165
            :|.|        .||:::   ...:.:.:||.:.|.     ...|.|.|||     |..:|:..:
Worm   141 NIDPCSELEVAVAAFSEDGIGNESKELKISSPKPTA-----NPKLDLLELQYLNTTLVSDFYQAN 200

Human   166 CDIR---------WMQLWQEQGEAKLNSQNLY----CINADGSQ-LPLFRMNISQCDLPEISVSH 216
            ..:.         |.     .|...|:.|.|:    |::.|.|| :|          :|:..|..
Worm   201 ATVHVEFRYKTDPWF-----LGPDDLDVQPLFHLISCVDPDLSQGIP----------VPDFDVHV 250

Human   217 VNLTVREGDNAVITCNGSGSPLPDVDW-IVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGF 280
            .|.|:         ....||.:.|... .|..|||:.:.:.|           |:..:.|..:..
Worm   251 KNSTI---------STSIGSDMMDRKCRYVYYLQSVMSKKCN-----------TMTEMPSPPSSA 295

Human   281 TLTCIAENVVGMSNASVALTVYYPP----------RVVS-----LEEPELRLEHCIEF--VVRGN 328
            ..|...|..:..:...|.:..|.||          .|:|     |.:|...|...:.|  |.|.|
Worm   296 LQTIQVECDIVKNAPCVKVPSYQPPLCGMVENVAFSVLSRDRENLNDPASNLTVNVTFIPVTRNN 360

Human   329 PPPTLHWL---------HNGQP-----LRESKIIHVEYYQEGEISEG-CLLFNKPTHYNNGNYTL 378
            ..|||:::         |..:.     :..:.:|..|....|..|.| ||.       .|.|.::
Worm   361 EMPTLYYIGIFGTASEYHTKEEETFLGVNITHVIGKESSCTGFDSSGNCLA-------ENLNRSI 418

Human   379 IAKNPLGTANQTINGHFL-----------------KEPFPESTDNFILFDEVSPTPPITVTHKPE 426
            :.:   |...:|:.|..:                 .:.|....|..:|....|..|
Worm   419 VLQ---GIHPKTLYGLTICAVKDIRNLTLPDVTLDSKSFRAKADRIMLVAHTSNNP--------- 471

Human   427 EDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTP 491
                 |.:.:|:...:.|:::|..|:|..|.|:....||     ...:.:.... :::|..|..|
Worm   472 -----VGMIIGIVIGSLVVILVAIVVIWFYFRKKSENMK-----FKFQMEQVGK-NNMNRYIDFP 525

Human   492 SSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVL--KRELGEGAFGKVFL 554
                            |...:|.               :..|:||::::  .::||.||||.|:|
Worm   526 ----------------IMAAKND---------------IWEIERRNLIIHNDKKLGSGAFGAVYL 559

Human   555 AECYNLS-PTKD-------------KMLVAVKALKDPTLA---ARKDFQREAELLTNL-QHEHIV 601
            .:....| ..||             ...||||.|  |..|   ::.:|.||..|:..| .||.:|
Worm   560 GKLIGKSLAHKDANSPLGINLMRAENCQVAVKML--PEYADEMSKHEFLREIALMKTLGYHERLV 622

Human   602 KFYGVCGDGDPLIMVFEYMKHGDLNKFLRA---------------HGP------DAMILVDGQPR 645
            .......:.:||.:|.||..:|||.||||.               |.|      |..::|.
Worm   623 NMLACVTESEPLCLVVEYCDNGDLLKFLRERCKYMMKLDDLGINYHDPPENENYDTNMIVT---- 683

Human   646 QAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYS--TD 708
                   |.|:|..|.||:.|:.||:.:.|||||:|.||.||......||||||:.|.:|:  :.
Worm   684 -------LKQLLQFAVQISYGLEYLSQKGFVHRDVAARNVLVHEGTACKIGDFGLCRYIYADQSQ 741

Human   709 YYREGPCQKGPFSVVWQRQRLAATAASTVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWE 773
            |..:|                           ..||::||.||:|.:.:|:.:||:||||::|:|
Worm   742 YKSKG---------------------------GKLPLKWMSPEAIRHYEFSIKSDIWSFGILLFE 779

Human   774 IFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEI 831
            :.|.|..|:..:...:|:..:..|..:|:|..||:..||||:.||..:|..|:...::
Worm   780 VITLGGSPYPGMPPEDVLPFLEGGGRIEKPDNCPENFYDVMMQCWNADPDDRIEFSDV 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NTRK3	XP_016877743.1	LRR_8	103..160	CDD:290566	18/77 (23%)
		leucine-rich repeat	105..128	CDD:275378	8/33 (24%)
		leucine-rich repeat	129..151	CDD:275378	3/21 (14%)
		leucine-rich repeat	152..164	CDD:275378	6/16 (38%)
		TPKR_C2	163..208	CDD:293525	10/58 (17%)
		Ig_TrkABC_d4	211..301	CDD:143173	16/90 (18%)
		IG_like	218..301	CDD:214653	15/83 (18%)
		Ig_TrKABC_d5	319..396	CDD:143172	20/93 (22%)
		PTKc_TrkC	532..843	CDD:270676	107/343 (31%)
		TyrKc	538..835	CDD:197581	104/337 (31%)
hir-1	NP_504458.1	fn3	85..163	CDD:365830	16/85 (19%)
hir-1	NP_504458.1	PTKc	547..842	CDD:270623	104/331 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910