DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NTRK3 and ark-1

DIOPT Version :9

Sequence 1:	XP_016877743.1	Gene:	NTRK3 / 4916	HGNCID:	8033	Length:	850	Species:	Homo sapiens
Sequence 2:	NP_001255654.1	Gene:	ark-1 / 178218	WormBaseID:	WBGene00000186	Length:	1043	Species:	Caenorhabditis elegans

Alignment Length:	312	Identity:	114/312 - (36%)
Similarity:	164/312 - (52%)	Gaps:	50/312 - (16%)

- Green bases have known domain annotations that are detailed below.

Human   527 DTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKAL-KDPTLAARKDFQREAE 590
            |.:|..|::  |.|.:|||:|.||.|:.|...| |...|.:.||||.: .|..||....|.:||.
Worm   104 DHHVIPIEK--ITLCKELGQGEFGSVWQAGWKN-SAGSDVIQVAVKCVGSDKLLATSSSFLQEAA 165

Human   591 LLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQ 655
            ::|.::|||:|:.|||..|...:::|.|....|.|.:.|  |.|   .|.|..|
Worm   166 IMTRMRHEHVVRLYGVVLDTKKIMLVSELATCGSLLECL--HKP---ALRDSFP----------- 214

Human   656 MLHI----ASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDV-YSTDYYREGPC 715
             :|:    |.|||.||.||..|..:|||||.||.||.:..||||.|||:||.: ...||||
Worm   215 -VHVLCDYAEQIAMGMSYLELQRLIHRDLAARNVLVFSPKLVKISDFGLSRSLGIGEDYYR---- 274

Human   716 QKGPFSVVWQRQRLAATAASTVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQ 780
                               |....:..|||.|..||.|.:.|||::||||::||.:||:|:||:.
Worm   275 -------------------SEFTPNLKLPIAWCAPECINFLKFTSKSDVWAYGVTIWEMFSYGEM 320

Human   781 PWFQLSNTEVIECITQGR-VLERPRVCPKEVYDVMLGCWQREPQQRLNIKEI 831
            ||...|..:::|.:.:.: :|.||:.||:::||::...|..:.|.|....:|
Worm   321 PWKGRSGAQILELVDRKKELLTRPKACPEDIYDMLKETWTHQVQDRPTFSDI 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NTRK3	XP_016877743.1	LRR_8	103..160	CDD:290566
		leucine-rich repeat	105..128	CDD:275378
		leucine-rich repeat	129..151	CDD:275378
		leucine-rich repeat	152..164	CDD:275378
		TPKR_C2	163..208	CDD:293525
		Ig_TrkABC_d4	211..301	CDD:143173
		IG_like	218..301	CDD:214653
		Ig_TrKABC_d5	319..396	CDD:143172
		PTKc_TrkC	532..843	CDD:270676	112/307 (36%)
		TyrKc	538..835	CDD:197581	111/301 (37%)
ark-1	NP_001255654.1	SAM_superfamily	14..71	CDD:301707
		TyrKc	113..376	CDD:197581	111/301 (37%)
		PTKc_Ack_like	117..378	CDD:270636	109/297 (37%)
		SH3	384..434	CDD:214620
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910