DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NTRK3 and kin-15

DIOPT Version :9

Sequence 1:	XP_016877743.1	Gene:	NTRK3 / 4916	HGNCID:	8033	Length:	850	Species:	Homo sapiens
Sequence 2:	NP_741035.2	Gene:	kin-15 / 174498	WormBaseID:	WBGene00002199	Length:	488	Species:	Caenorhabditis elegans

Alignment Length:	492	Identity:	127/492 - (25%)
Similarity:	205/492 - (41%)	Gaps:	123/492 - (25%)

- Green bases have known domain annotations that are detailed below.

Human   371 YNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIA 435
            |:|..:....:||          |...:     ..|.:..|::                |.:.|.
Worm    23 YSNSTFESFTENP----------HISSQ-----ISNVLYMDQM----------------FIIYIL 56

Human   436 VGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSL-DAGPD 499
            :      |:||:::.|::....|.|:..|:....:.:         ...|..:...|:: |..|
Worm    57 I------CILLILISVIVYLSKRYSQQMMQSSDNITN---------RRSNPEVRNKSNIYDLPP- 105

Human   500 TVVIGMTRI----PVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNL 560
              ::.:|.:    |:::.|...|..:....|...:...|..  :.:.:||.|.||:|    ||.|
Worm   106 --LLDVTSVNEETPIVKRPINERIENLEFDPRFEIDQAKLE--ISEDKLGSGFFGEV----CYGL 162

Human   561 ---------SPTKDKMLVAVKALKDPTLA-ARKDFQREAELLTNL-QHEHIVKFYGV----CGDG 610
                     :.|..|:.||||...|||.. ..|..:.|.:|:..: ::.:|:...|.    .|..
Worm   163 LSMRTSNTETDTLQKLSVAVKQSNDPTQENQEKMIEDETKLMCAIGRNPNILAIIGAVTANSGSA 227

Human   611 DPLIMVFEYMKHGDLNKFLR----------AHGPDAMIL--------------VDGQPRQAKGEL 651
            ..|::| |:::.|||.|||.          .:..:..:|              .|....::...|
Worm   228 RNLLIV-EFVECGDLLKFLEEKKSIFKDELVYEKNGYLLPKSIRRKTYMFNENEDDVIEESLDSL 291

Human   652 GLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYREGPCQ 716
            ..|.:|..:.|||.||.||||...||||||.||.|:..|..::|.|||::|......|||
Worm   292 CTSDLLSFSYQIAEGMEYLASIPCVHRDLALRNVLLNKNKTIRIADFGLARKYQVDGYYR----- 351

Human   717 KGPFSVVWQRQRLAATAASTVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQP 781
                              .|.|..|.:|.|||.||.:...|.|.:|||||:||.|:|:|:.|:.|
Worm   352 ------------------ITKGVGTPMPARWMAPEVMREGKCTEKSDVWSYGVSLYEMFSLGELP 398

Human   782 WFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCW 818
            :..:||::|.|.:.||..|..|:.|..::||.|...|
Worm   399 YSNVSNSDVFEHVVQGNQLPMPQYCHPKMYDRMKQFW 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NTRK3	XP_016877743.1	LRR_8	103..160	CDD:290566
		leucine-rich repeat	105..128	CDD:275378
		leucine-rich repeat	129..151	CDD:275378
		leucine-rich repeat	152..164	CDD:275378
		TPKR_C2	163..208	CDD:293525
		Ig_TrkABC_d4	211..301	CDD:143173
		IG_like	218..301	CDD:214653
		Ig_TrKABC_d5	319..396	CDD:143172	5/24 (21%)
		PTKc_TrkC	532..843	CDD:270676	102/326 (31%)
		TyrKc	538..835	CDD:197581	101/320 (32%)
kin-15	NP_741035.2	STYKc	147..452	CDD:214568	101/317 (32%)
kin-15	NP_741035.2	PTKc	148..453	CDD:270623	101/316 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910