DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NTRK3 and ntrk3

DIOPT Version :9

Sequence 1:	XP_016877743.1	Gene:	NTRK3 / 4916	HGNCID:	8033	Length:	850	Species:	Homo sapiens
Sequence 2:	XP_031755091.1	Gene:	ntrk3 / 100487541	XenbaseID:	XB-GENE-489713	Length:	828	Species:	Xenopus tropicalis

Alignment Length:	850	Identity:	699/850 - (82%)
Similarity:	752/850 - (88%)	Gaps:	25/850 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     1 MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNS 65
            |||.|.|.|||||||.||.|:|||.:||  ||||||||:.|||||.:|||||:|||||||:||.|
Frog     4 MDVLLLPGKCSFWRILLLWSLWLDSLGS--ACPANCVCNSTEINCTKPDDGNIFPLLEGQESGTS 66

Human    66 NGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLR 130
            |||:.:|||||||||||||||||:.||||||||||||||||||||||||||:||||||||||.|:
Frog    67 NGNSIVNITDISRNITSIHIENWKGLHTLNAVDMELYTGLQKLTIKNSGLRNIQPRAFAKNPQLQ 131

Human   131 YINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGS 195
            |||||.||||:|||||||.|.|.:|::|:|.|||||:|||:||.|.:.||.|..|.|||:|:||.
Frog   132 YINLSGNRLTSLSWQLFQNLELVDLRIERNHFNCSCEIRWIQLGQAKNEANLKRQQLYCMNSDGV 196

Human   196 QLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNW 260
            .:||..|||||||||||||||.:|.|:||||||:|||||||||||||||||.|.||||||:|:||
Frog   197 VIPLQEMNISQCDLPEISVSHSSLIVQEGDNAVVTCNGSGSPLPDVDWIVTNLHSINTHQSNVNW 261

Human   261 TNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVV 325
            ||||:||||||||..|||||.|||||||||||:||||.||||:|||::||:||..||||||||||
Frog   262 TNVHSINLTLVNVAREDNGFILTCIAENVVGMTNASVPLTVYFPPRILSLKEPVSRLEHCIEFVV 326

Human   326 RGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQT 390
            .|||||.|:|.|||:.|||...|..|.|::..::||||||||||||.||||||:|.|.||.|.||
Frog   327 LGNPPPVLNWFHNGKALREVDFIRTELYRQDNVTEGCLLFNKPTHYYNGNYTLMASNKLGVARQT 391

Human   391 INGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINK 455
            :..|||.:||||:...|.:.|..||||||:||||||||||||||||||||||||||||||::|||
Frog   392 VYAHFLGQPFPETDYFFSVADFGSPTPPISVTHKPEEDTFGVSIAVGLAAFACVLLVVLFIVINK 456

Human   456 YGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQG 520
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog   457 YGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQG 521

Human   521 HNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDF 585
            |||||||||||:||||||||||||||||||||||||||||||||||||||||.||||||||||||
Frog   522 HNCHKPDTYVQYIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKTLKDPTLAARKDF 586

Human   586 QREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGE 650
            ||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||.||:
Frog   587 QREAELLTNLQHDHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQTKGD 651

Human   651 LGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYREGPC 715
            ||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||
Frog   652 LGLSQMLHIATQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYR---- 712

Human   716 QKGPFSVVWQRQRLAATAASTVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQ 780
                               ..||||||||||||||||||||||||||||||||||||||||||||
Frog   713 -------------------VRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQ 758

Human   781 PWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIY 845
            |||||||||||||||||||||||||.||||||:||||||||||.|||||||.|||.|||||:|||
Frog   759 PWFQLSNTEVIECITQGRVLERPRVAPKEVYDIMLGCWQREPQLRLNIKEICKILQALGKASPIY 823

Human   846 LDILG 850
            |||||
Frog   824 LDILG 828

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NTRK3	XP_016877743.1	LRR_8	103..160	CDD:290566	45/56 (80%)
		leucine-rich repeat	105..128	CDD:275378	21/22 (95%)
		leucine-rich repeat	129..151	CDD:275378	17/21 (81%)
		leucine-rich repeat	152..164	CDD:275378	5/11 (45%)
		TPKR_C2	163..208	CDD:293525	27/44 (61%)
		Ig_TrkABC_d4	211..301	CDD:143173	74/89 (83%)
		IG_like	218..301	CDD:214653	68/82 (83%)
		Ig_TrKABC_d5	319..396	CDD:143172	49/76 (64%)
		PTKc_TrkC	532..843	CDD:270676	274/310 (88%)
		TyrKc	538..835	CDD:197581	262/296 (89%)
ntrk3	XP_031755091.1	LRR_8	104..163	CDD:404697	46/58 (79%)
		leucine-rich repeat	106..129	CDD:275378	21/22 (95%)
		leucine-rich repeat	130..152	CDD:275378	17/21 (81%)
		leucine-rich repeat	153..165	CDD:275378	5/11 (45%)
		TPKR_C2	164..209	CDD:407151	27/44 (61%)
		Ig_3	211..289	CDD:404760	64/77 (83%)
		Ig strand B	227..234	CDD:409353	5/6 (83%)
		Ig strand C	241..247	CDD:409353	5/5 (100%)
		Ig strand D	255..261	CDD:409353	3/5 (60%)
		Ig strand E	264..276	CDD:409353	10/11 (91%)
		Ig strand F	280..289	CDD:409353	7/8 (88%)
		Ig strand G	291..302	CDD:409353	8/10 (80%)
		Ig	305..397	CDD:416386	59/91 (65%)
		Ig strand A	306..312	CDD:409353	3/5 (60%)
		Ig strand A'	314..317	CDD:409353	1/2 (50%)
		Ig strand B	320..328	CDD:409353	7/7 (100%)
		Ig strand C	331..338	CDD:409353	4/6 (67%)
		Ig strand C'	341..344	CDD:409353	0/2 (0%)
		Ig strand D	349..355	CDD:409353	2/5 (40%)
		Ig strand E	359..367	CDD:409353	5/7 (71%)
		Ig strand F	375..383	CDD:409353	6/7 (86%)
		Ig strand G	386..394	CDD:409353	4/7 (57%)
		PTKc_TrkC	533..821	CDD:270676	274/310 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	261	1.000	Domainoid score	I11242
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H49183
Inparanoid	1	1.050	1431	1.000	Inparanoid score	I1551
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153083at33208
OrthoFinder	1	1.000	-	-		FOG0009232
OrthoInspector	1	1.000	-	-		oto152553
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6973
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.060