Protein Alignment NTRK3 and ntrk3

DIOPT Version :10

• Sequence 1: XP_016877743.1
• Gene: NTRK3 / 4916
• HGNCID: 8033
• Length: 850
• Species: Homo sapiens
• Sequence 2: XP_031755091.1
• Gene: ntrk3 / 100487541
• XenbaseID: XB-GENE-489713
• Length: 828
• Species: Xenopus tropicalis
• Alignment Length: 850
• Identity: 699/850 - (82%)
• Similarity: 752/850 - (88%)
• Gaps: 25/850 - (2%)

Human     1 MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNS 65
            |||.|.|.|||||||.||.|:|||.:||  ||||||||:.|||||.:|||||:|||||||:||.|
 Frog     4 MDVLLLPGKCSFWRILLLWSLWLDSLGS--ACPANCVCNSTEINCTKPDDGNIFPLLEGQESGTS 66

Human    66 NGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLR 130
            |||:.:|||||||||||||||||:.||||||||||||||||||||||||||:||||||||||.|:
 Frog    67 NGNSIVNITDISRNITSIHIENWKGLHTLNAVDMELYTGLQKLTIKNSGLRNIQPRAFAKNPQLQ 131

Human   131 YINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGS 195
            |||||.||||:|||||||.|.|.:|::|:|.|||||:|||:||.|.:.||.|..|.|||:|:||.
 Frog   132 YINLSGNRLTSLSWQLFQNLELVDLRIERNHFNCSCEIRWIQLGQAKNEANLKRQQLYCMNSDGV 196

Human   196 QLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNW 260
            .:||..|||||||||||||||.:|.|:||||||:|||||||||||||||||.|.||||||:|:||
 Frog   197 VIPLQEMNISQCDLPEISVSHSSLIVQEGDNAVVTCNGSGSPLPDVDWIVTNLHSINTHQSNVNW 261

Human   261 TNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVV 325
            ||||:||||||||..|||||.|||||||||||:||||.||||:|||::||:||..||||||||||
 Frog   262 TNVHSINLTLVNVAREDNGFILTCIAENVVGMTNASVPLTVYFPPRILSLKEPVSRLEHCIEFVV 326

Human   326 RGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQT 390
            .|||||.|:|.|||:.|||...|..|.|::..::||||||||||||.||||||:|.|.||.|.||
 Frog   327 LGNPPPVLNWFHNGKALREVDFIRTELYRQDNVTEGCLLFNKPTHYYNGNYTLMASNKLGVARQT 391

Human   391 INGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINK 455
            :..|||.:||||:...|.:.|..||||||:||||||||||||||||||||||||||||||::|||
 Frog   392 VYAHFLGQPFPETDYFFSVADFGSPTPPISVTHKPEEDTFGVSIAVGLAAFACVLLVVLFIVINK 456

Human   456 YGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQG 520
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   457 YGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQG 521

Human   521 HNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDF 585
            |||||||||||:||||||||||||||||||||||||||||||||||||||||.||||||||||||
 Frog   522 HNCHKPDTYVQYIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKTLKDPTLAARKDF 586

Human   586 QREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGE 650
            ||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||.||:
 Frog   587 QREAELLTNLQHDHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQTKGD 651

Human   651 LGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYREGPC 715
            ||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   652 LGLSQMLHIATQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYR---- 712

Human   716 QKGPFSVVWQRQRLAATAASTVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQ 780
                               ..||||||||||||||||||||||||||||||||||||||||||||
 Frog   713 -------------------VRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQ 758

Human   781 PWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIY 845
            |||||||||||||||||||||||||.||||||:||||||||||.|||||||.|||.|||||:|||
 Frog   759 PWFQLSNTEVIECITQGRVLERPRVAPKEVYDIMLGCWQREPQLRLNIKEICKILQALGKASPIY 823

Human   846 LDILG 850
            |||||
 Frog   824 LDILG 828

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NTRK3	XP_016877743.1	LRR_8	103..160	CDD:404697	45/56 (80%)
		leucine-rich repeat	105..128	CDD:275378	21/22 (95%)
		leucine-rich repeat	129..151	CDD:275378	17/21 (81%)
		leucine-rich repeat	152..164	CDD:275378	5/11 (45%)
		LRRCT_2	163..208	CDD:465313	27/44 (61%)
		ig	214..299	CDD:395002	70/84 (83%)
		Ig strand B	227..231	CDD:409568	2/3 (67%)
		Ig strand C	240..244	CDD:409568	3/3 (100%)
		Ig strand E	266..270	CDD:409568	3/3 (100%)
		Ig strand F	281..286	CDD:409568	3/4 (75%)
		Ig strand G	294..297	CDD:409568	2/2 (100%)
		IgI_TrKABC_d5	304..396	CDD:409360	59/91 (65%)
		Ig strand A	305..311	CDD:409360	3/5 (60%)
		Ig strand A'	313..316	CDD:409360	1/2 (50%)
		Ig strand B	319..327	CDD:409360	7/7 (100%)
		Ig strand C	330..337	CDD:409360	4/6 (67%)
		Ig strand C'	340..343	CDD:409360	0/2 (0%)
		Ig strand D	348..354	CDD:409360	2/5 (40%)
		Ig strand E	358..366	CDD:409360	5/7 (71%)
		Ig strand F	374..382	CDD:409360	6/7 (86%)
		Ig strand G	385..393	CDD:409360	4/7 (57%)
		PTKc_TrkC	532..843	CDD:270676	274/310 (88%)
ntrk3	XP_031755091.1	LRR	35..>161	CDD:443914	102/125 (82%)
		LRR_8	104..163	CDD:404697	46/58 (79%)
		leucine-rich repeat	106..129	CDD:275378	21/22 (95%)
		leucine-rich repeat	130..152	CDD:275378	17/21 (81%)
		leucine-rich repeat	153..165	CDD:275378	5/11 (45%)
		LRRCT_2	164..209	CDD:465313	27/44 (61%)
		Ig_3	211..289	CDD:464046	64/77 (83%)
		Ig	305..397	CDD:472250	59/91 (65%)
		Ig strand B	320..324	CDD:409360	3/3 (100%)
		Ig strand C	333..337	CDD:409360	1/3 (33%)
		Ig strand E	362..366	CDD:409360	3/3 (100%)
		Ig strand F	376..381	CDD:409360	4/4 (100%)
		Ig strand G	389..392	CDD:409360	1/2 (50%)
		PTKc_TrkC	533..821	CDD:270676	274/310 (88%)