Protein Alignment ATP2B2 and Atpalpha

DIOPT Version :10

• Sequence 1: NP_001001331.1
• Gene: ATP2B2 / 491
• HGNCID: 815
• Length: 1243
• Species: Homo sapiens
• Sequence 2: NP_732572.1
• Gene: Atpalpha / 48971
• FlyBaseID: FBgn0002921
• Length: 1041
• Species: Drosophila melanogaster
• Alignment Length: 1170
• Identity: 307/1170 - (26%)
• Similarity: 489/1170 - (41%)
• Gaps: 349/1170 - (29%)

Human    38 RGTEAVVKIKETYGD-------------TEAICRRLKTSPVEGL--PGTAPDLEKRKQIFGQNFI 87
            |...|.|..||...|             .|.:.:|.:|.|..||  .....:||:.    |.|.:
  Fly    38 RKMPAKVNKKENLDDLKQELDIDFHKISPEELYQRFQTHPENGLSHAKAKENLERD----GPNAL 98

Human    88 -PPKKPKT-----------FLQLVWEALQDVTLIILEIAAIISLGLSFYHPPGEGNEGCATAQGG 140
             |||:...           |..|:|     :..|:..:|..|.               .:|::..
  Fly    99 TPPKQTPEWVKFCKNLFGGFAMLLW-----IGAILCFVAYSIQ---------------ASTSEEP 143

Human   141 AEDEGEAEAGWIEGAAILLSVI--CVVLVTA-FNDWSKEKQFRGLQSRIEQEQKF-TVVRAGQVV 201
            |:|.            :.|.::  .||:||. |:.:.:.|..:.::|......:| ||:|.|:.:
  Fly   144 ADDN------------LYLGIVLSAVVIVTGIFSYYQESKSSKIMESFKNMVPQFATVIREGEKL 196

Human   202 QIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQVRKSVD---KDP-----ML 258
            .:...::|:||:.:||:||.:|||...|:..:.|:|.|||||||:...:..:   ::|     :.
  Fly   197 TLRAEDLVLGDVVEVKFGDRIPADIRIIEARNFKVDNSSLTGESEPQSRGAEFTHENPLETKNLA 261

Human   259 LSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGAGGEEEEKKDKKGVKKGDGLQLPAADGAAASNA 323
            ...|:.:||:.:.:|.:.|.::..|.|
  Fly   262 FFSTNAVEGTAKGVVISCGDHTVMGRI-------------------------------------- 288

Human   324 ADSANASLVNGKMQDGNVDASQSKAKQQDGAAAMEMQPLKSAEGGDADDRKKASMHKKEKSVLQG 388
                 |.|.:|                           |.:.|
  Fly   289 -----AGLASG---------------------------LDTGE---------------------- 299

Human   389 KLTKLAVQIGKAGLVMSAITVIILVLYFTVDTFVVNKKPWLPECTPVYVQYFVKFFIIGVTVLVV 453
              |.:|.:|.....:::.:.|.:.|.:|.: .|::... ||.          ...|:||  ::|.
  Fly   300 --TPIAKEIHHFIHLITGVAVFLGVTFFVI-AFILGYH-WLD----------AVIFLIG--IIVA 348

Human   454 AVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGD 518
            .|||||...||:.|..:.|:|...|.||::|:|.||:|:.:.||||||||||.|||||...:..:
  Fly   349 NVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDN 413

Human   519 -------------VHYKEIPDPSSINTKTMELLINAIAINSAYTTKILPPEKEGA------LPRQ 564
                         |.|    |.:|...|.:..:  |...|.|        |.:|.      |.::
  Fly   414 QIIEADTTEDQSGVQY----DRTSPGFKALSRI--ATLCNRA--------EFKGGQDGVPILKKE 464

Human   565 V-GNKTECGL-------LGFVLDLKQDYEPVRSQMPEEKLYKVYTFNSVRKSMSTVIKLPDES-- 619
            | |:.:|..|       ||.|:::::..:.: :::|         |||..|...::.:..|.:
  Fly   465 VSGDASEAALLKCMELALGDVMNIRKRNKKI-AEVP---------FNSTNKYQVSIHETEDTNDP 519

Human   620 -FRMYSKGASEIVLKKCCKI-LNGAGEPRVFRPRDRDEMVKKVIEP--MACDGLRTICVAYRDF- 679
             :.:..|||.|.:|::|..| :||       :.:..||.:|:....  |...||....:.:.||
  Fly   520 RYLLVMKGAPERILERCSTIFING-------KEKVLDEEMKEAFNNAYMELGGLGERVLGFCDFM 577

Human   680 -PSSPEP-----DWDNENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTA 738
             ||...|     :.|:.|..::.|..:.::.:.||.|..||:|:.||:.|||.|.|||||:..||
  Fly   578 LPSDKYPNGFKFNTDDINFPIDNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITA 642

Human   739 RAIAIKCGIIHPG----EDF---LCLEGKEFNRRIRN-------EKGEIEQERIDKIWPKLR--- 786
            :|||...|||..|    ||.   |.:...|.|.|...       |..::..:::|:|   ||
  Fly   643 KAIAKSVGIISEGNETVEDIAQRLNIPVSEVNPREAKAAVVHGAELRDVSSDQLDEI---LRYHT 704

Human   787 --VLARSSPTDKHTLVKGIIDSTHTEQRQ--VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKE 847
              |.||:||..|..:|:|.       ||.  :|||||||.||.|||||||:|.||||||:||:|:
  Fly   705 EIVFARTSPQQKLIIVEGC-------QRMGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQ 762

Human   848 ASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNV--VAVIVAFTGACITQDSPLK--AV 908
            |:|:||.||||:|||..|..||.::|::.|.:.:.||.|:  ::..:||    |..|.||.  .|
  Fly   763 AADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLAF----ILCDIPLPLGTV 823

Human   909 QMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYQLALIFTLLFVG 973
            .:|.::|..|...:::||.|.....::.|.|   ..|...:.:...::..|..|:.:|
  Fly   824 TILCIDLGTDMVPAISLAYEHAEADIMKRPP---RDPFNDKLVNSRLISMAYGQIGMI------- 878

Human   974 EKMFQIDSGRNAPLHSPPSEHYTIIFNTFVMMQLFNEINARKIHGERNVFDGIFRNPIFCTIVLG 1038
                |..:|               .|..||:| ..|....:|:.|.|.::|....|.:  |...|
  Fly   879 ----QAAAG---------------FFVYFVIM-AENGFLPKKLFGIRKMWDSKAVNDL--TDSYG 921

Human  1039 -----------------TFAIQIVIVQFGG----KPFSCSPLQLDQWMWCIFIGLGELVWGQVIA 1082
                             .|.|.||:||:..    |....|..|.....|.:..|   ||:..|:|
  Fly   922 QEWTYRDRKTLEYTCHTAFFISIVVVQWADLIICKTRRNSIFQQGMRNWALNFG---LVFETVLA 983

Human  1083  1082
              Fly   984  983

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP2B2	NP_001001331.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..24
		ATPase-IIB_Ca	12..1087	CDD:273668	307/1170 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	334..381		3/46 (7%)
		Calmodulin-binding subdomain A. /evidence=ECO:0000250	1123..1140
		ATP_Ca_trans_C	1126..1172	CDD:463575
		Calmodulin-binding subdomain B. /evidence=ECO:0000250	1141..1150
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1194..1243
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	304/1163 (26%)