back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP2B2 and PMCA

DIOPT Version :10

Sequence 1:	NP_001001331.1	Gene:	ATP2B2 / 491	HGNCID:	815	Length:	1243	Species:	Homo sapiens
Sequence 2:	NP_001014689.3	Gene:	PMCA / 43787	FlyBaseID:	FBgn0259214	Length:	1255	Species:	Drosophila melanogaster

Alignment Length:	1257	Identity:	737/1257 - (58%)
Similarity:	890/1257 - (70%)	Gaps:	107/1257 - (8%)

- Green bases have known domain annotations that are detailed below.

Human    23 EFGCTMEELRSLMELRGTEAVVKIKETYGDTEAICRRLKTSPVEGLPGTAPDLEKRKQIFGQNFI 87
            ::|.::::||.|||.||.|.|:||.|. |....:|::|.|||.|||.|:..|.|.|::.||.|.|
  Fly    10 QYGISLKQLRELMEHRGREGVMKIAEN-GGIHELCKKLYTSPNEGLSGSKADEEHRRETFGSNVI 73

Human    88 PPKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYHPPGEGNEGCATAQGGAEDEGEAEAGWI 152
            |||.|||||.|||||||||||||||:||::|||||||.|   .:|.....|     |.|...|||
  Fly    74 PPKPPKTFLTLVWEALQDVTLIILEVAALVSLGLSFYKP---ADEDAPVLQ-----EEEEHHGWI 130

Human   153 EGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVVRAGQVVQIPVAEIVVGDIAQVK 217
            ||.|||:|||.||:||||||:|||:||||||:|||.|.||:|:|.|:|.||.|.:|:||||||||
  Fly   131 EGLAILISVIVVVIVTAFNDYSKERQFRGLQNRIEGEHKFSVIRGGEVCQISVGDILVGDIAQVK 195

Human   218 YGDLLPADGLFIQGNDLKIDESSLTGESDQVRKSVDKDPMLLSGTHVMEGSGRMLVTAVGVNSQT 282
            |||||||||..||.||||:||||||||||.|:|..|.|||:|||||||||||:|:|||||||||.
  Fly   196 YGDLLPADGCLIQSNDLKVDESSLTGESDHVKKGPDVDPMVLSGTHVMEGSGKMVVTAVGVNSQA 260

Human   283 GIIFTLLGAGGEEEE---KKDKKGVKK--------GDGLQLPAADGAAASNAADSANASLVNGKM 336
            |||||||||..:|:|   ||.||..|:        |:........|:.|.:..::..:.:...:.
  Fly   261 GIIFTLLGAAVDEQEAEIKKMKKEAKRANKQKNLTGENDGRSQIKGSQAPSQRETVTSEITKSES 325

Human   337 QDGNVDASQSKAKQQDGAAAMEMQPLKSAEGGDADDRKKASMHKKEKSVLQGKLTKLAVQIGKAG 401
            :..::..|.|....:.|                         |||||||||.||||||:|||.||
  Fly   326 EGNHLPQSSSSGAAETG-------------------------HKKEKSVLQAKLTKLAIQIGYAG 365

Human   402 LVMSAITVIILVLYFTVDTFVVNKKPWLPECTPVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTIS 466
            ..::.:|||||::.|.:.|||:::|||    ...|....||..||||||||||||||||||||:|
  Fly   366 STIAVLTVIILIIQFCIKTFVIDEKPW----KNTYANNLVKHLIIGVTVLVVAVPEGLPLAVTLS 426

Human   467 LAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVHYKEIPDPSSIN 531
            |||||||||||||||||||||||||||||||||||||||||||||||:|:.:...|.:|..|.|.
  Fly   427 LAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYICEKLCKVLPTLSDIP 491

Human   532 TKTMELLINAIAINSAYTTKILPPEKEGALPRQVGNKTECGLLGFVLDLKQDYEPVRSQMPEEKL 596
            .....|:...|::|||||:.|:.....|.||.||||||||.|||||..|...|:.:|.::.|:|.
  Fly   492 QHVGNLITMGISVNSAYTSNIMAGHNPGDLPIQVGNKTECALLGFVQGLGVKYQSIRDEITEDKF 556

Human   597 YKVYTFNSVRKSMSTVIKLPDESFRMYSKGASEIVLKKCCKILNGAGEPRVFRPRDRDEMVKKVI 661
            .:|||||||||||.|||..|:..:|:|:||||||::|||..|....|....|....::.::::||
  Fly   557 TRVYTFNSVRKSMGTVIPRPNGGYRLYTKGASEIIMKKCAFIYGHEGTLEKFTRDMQERLIREVI 621

Human   662 EPMACDGLRTICVAYRDF-PSSP---------EPDWDNENDILNELTCICVVGIEDPVRPEVPEA 716
            |||||||||||.|||||| |...         ||:||:|.:|:..|||:||||||||||||||:|
  Fly   622 EPMACDGLRTISVAYRDFVPGKAAINEVHIDGEPNWDDEENIMTNLTCLCVVGIEDPVRPEVPDA 686

Human   717 IRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEDFLCLEGKEFNRRIRNEKGEIEQERIDKI 781
            |||||||||||||||||||||||:||.||||:.|.:|||.|||||||||||:..|:|:|..|||:
  Fly   687 IRKCQRAGITVRMVTGDNINTARSIASKCGILRPNDDFLILEGKEFNRRIRDSNGDIQQHLIDKV 751

Human   782 WPKLRVLARSSPTDKHTLVKGIIDSTHTEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAK 846
            |||||||||||||||:||||||||||.:|.|:|||||||||||||||||||||||||||||||||
  Fly   752 WPKLRVLARSSPTDKYTLVKGIIDSTVSENREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAK 816

Human   847 EASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQML 911
            |||||||||||||||||||||||||||||:||||||||||||||||||.|||..|||||||||||
  Fly   817 EASDIILTDDNFSSIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVIVAFIGACAVQDSPLKAVQML 881

Human   912 WVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYQLALIFTLLFVGEKM 976
            ||||||||.||||||||.||..|||||||||.||||||||||||||.|:|||.:||.|||||:.:
  Fly   882 WVNLIMDTLASLALATEFPTPDLLLRKPYGRTKPLISRTMMKNILGQALYQLIIIFGLLFVGDVI 946

Human   977 FQIDSGRNAPLHSPPSEHYTIIFNTFVMMQLFNEINARKIHGERNVFDGIFRNPIFCTIVLGTFA 1041
            ..|:|||...|::.|::|:||||||||||.||||||||||||:|||.:|:..||||.||.:.|..
  Fly   947 LDIESGRGQELNAGPTQHFTIIFNTFVMMTLFNEINARKIHGQRNVIEGLLTNPIFYTIWIFTMI 1011

Human  1042 IQIVIVQFGGKPFSCSPLQLDQWMWCIFIGLGELVWGQVIATIPTSRLKFLKEAGRLTQKEEIPE 1106
            .|::|:|:|...||...|.||||:||||.|:|.|||||:|.::||.:|..:...||...:|....
  Fly  1012 SQVLIIQYGKMAFSTKALTLDQWLWCIFFGIGTLVWGQLITSVPTRKLPKILSWGRGHPEEYTDG 1076

Human  1107 EELNED-VEEIDHAERELRRGQILWFRGLNRIQTQIRVVKAFRSSLYEGLEKPESRTSIH----- 1165
            ..|.|: .:.|| ::::.|.|||||.|||.|:|||:||::||||:| |.|.:..|..|:|
  Fly  1077 MNLGEERFDSID-SDKKPRAGQILWIRGLTRLQTQLRVIRAFRSTL-EDLNERRSMHSLHSLRSP 1139

Human  1166 ----------------------NFMAH---------PEFRIEDS----QPHIPLIDDTDLEEDAA 1195
                                  |::.|         |:.::..|    .|.|..||:...::...
  Fly  1140 RTGIPVAVGGGHPLYNFNLLNPNYIKHQQQQEPKLPPQTQLNVSSGMMSPDISYIDEDPQQQQRT 1204

Human  1196 L-----KQNSSPPSSLNKNNSA 1212
            |     .|.||.||::..:|.:
  Fly  1205 LHNGLTSQRSSMPSNVPSSNQS 1226

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.