Protein Alignment ATP2B2 and SPoCk

DIOPT Version :10

• Sequence 1: NP_001001331.1
• Gene: ATP2B2 / 491
• HGNCID: 815
• Length: 1243
• Species: Homo sapiens
• Sequence 2: NP_001262220.1
• Gene: SPoCk / 40495
• FlyBaseID: FBgn0052451
• Length: 1062
• Species: Drosophila melanogaster
• Alignment Length: 1162
• Identity: 290/1162 - (24%)
• Similarity: 472/1162 - (40%)
• Gaps: 325/1162 - (27%)

Human     1 MGDMTNSDFYSKNQRNESSHGGEFGCTMEELRSLMELRGTEAVVKIKETYGDTEAICRRLKTSPV 65
            |.|....|..:.:|:|.:........|.|.|.|..|          ..|:..:| :..||:....
  Fly    75 MKDCKEPDEDNVDQQNGNIIQTGLTLTPEMLLSTSE----------SSTHSASE-VAGRLQVDVR 128

Human    66 EGLPGTAPDLEKRKQIFGQN--FIPPKKPKTFLQLVW----EALQDVTLIILEIAAIISLGLSFY 124
            .||..|  :.:.|.:|.|.|  .:..:.|      .|    |..::..:::|..:|::|:.:..:
  Fly   129 TGLKWT--EAKYRAKIIGHNELLLVAEDP------TWKKYIEQFRNPLILLLLGSALVSVIMKQF 185

Human   125 HPPGEGNEGCATAQGGAEDEGEAEAGWIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQE 189
            .                           :..:|.::::.||.|....::..||....|:..:..|
  Fly   186 D---------------------------DAVSITIAILIVVTVAFIQEYRSEKSLEELKKLVPPE 223

Human   190 QKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQVRKSVDK 254
              ...:|.|::......|:|.|||..:..||.:|||....:..||.|||||.|||::..||..|
  Fly   224 --CHCLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAVDLSIDESSFTGETEPARKITD- 285

Human   255 DPMLLSGTHVME----------------GSGRMLVTAVGVNSQTGIIFTLLGAGGEEEEKKDKKG 303
              :||:.|:|.:                |:|:.:|.:.|..|:.|.:|.::.|   ||..|
  Fly   286 --VLLNNTNVKDHSNMKNIAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQA---EEAPK---- 341

Human   304 VKKGDGLQLPAADGAAASNAADSANASLVNGKMQDGNVDASQSKAKQQDGAAAMEMQPLKSAEGG 368
                                                                    .||
  Fly   342 --------------------------------------------------------TPL------ 344

Human   369 DADDRKKASMHKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDTFVVNKKPWLPECT 433
                       :|...:|..:|:..:..|         |.||:|:             .|| :..
  Fly   345 -----------QKSMDILGAQLSFYSFLI---------IGVIMLL-------------GWL-QGK 375

Human   434 PVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICS 498
            |:     .:.|.|.|::.|.|:|||||:.||::||..|.:|.|.|::|:.|...||:|....|||
  Fly   376 PL-----SEMFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPTVETLGCVNVICS 435

Human   499 DKTGTLTTNRMTVV-----QAYV-----------GDVHYKEIPDPSSINTKTMELLINAIAINSA 547
            |||||||.|.||..     ..|:           |::|.:...:.....|....||......|:|
  Fly   436 DKTGTLTKNEMTATIIITSDGYMADVTGAGYNDQGEIHIRHCNNVEMAKTNITNLLEIGAVCNNA 500

Human   548 YTTKILPPEKEGALPRQVGNKTECGLLGFVLD-----LKQDYEPVRSQMPEEKLYKVYTFNSVRK 607
            |.       :.|.|   :|..||..|:...:.     ..::|  ||.|        .|.|:|.:|
  Fly   501 YI-------QNGTL---LGQPTEGALVAVAMKNGMYATAENY--VRIQ--------EYPFSSEQK 545

Human   608 SMSTVIKL-------PDESFRMYSKGASEIVLKKCCKILNGAGEPRVFRPRDRDEMVKKVIEPMA 665
            .|:  :|.       .:|.|  ::|||.|.:|.:|.|...|. :......::..|.:.:..| :.
  Fly   546 MMA--VKCIHKYNNNKEEIF--FAKGALETLLPQCTKYQFGT-QTVPLTKQNEAEFLAEAYE-IG 604

Human   666 CDGLRTICVAYRDFPSSPEPDWDNENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMV 730
            ..|||.:.:|              :...:.:|....:|||.||.||.|.|:|....::|:.|:||
  Fly   605 RKGLRVLALA--------------KGRSMQDLIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMV 655

Human   731 TGDNINTARAI------------AIKCGIIHPGEDFL---------CLEG--KEFNRRIRNEKG- 771
            |||...||.||            ||.......|....         |||.  ||.......::|
  Fly   656 TGDAQETALAIDPSRRLQAVPTHAIPAWPTAGGVPLCSASACCSTNCLENAMKEIYLTALAQQGL 720

Human   772 ------------------------EIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTHTEQR 812
                                    ::.:.::||:...:.|..|.||..|..:||.:       ||
  Fly   721 PLVTANLIGIDTIHHQTLSGQEMDQMNEHQLDKVANNVSVFYRVSPRHKLEIVKSL-------QR 778

Human   813 --QVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSI 875
              .:|.:||||.|||.||||||:|.|||..||||.|||:|:||.:|:|.:|:.|:..|:.::.:|
  Fly   779 SGNIVGMTGDGVNDGVALKKADIGIAMGKNGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNI 843

Human   876 SKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPY 940
            ..|::|||:.::.|:.:......:...:||.|:|:||:|:|||...:.:|..||....:|.:||.
  Fly   844 RNFVRFQLSTSIAALALIALATLMDIANPLNAMQILWINIIMDGPPAQSLGVEPVDHDVLKQKPR 908

Human   941 GRNKPLISRTMMKNILGHAVYQLALIFTLLFVGEKMFQIDSGRNAPLHSPPSEHYTIIFNTFVMM 1005
            ...:|:|:::::.|:|..|  .:.::.||.....:|.....|:.       ....|:.|..||..
  Fly   909 NVKQPMITKSVVVNVLLSA--SIIVLGTLWVFQREMADGTLGKT-------KRDTTMTFTCFVFF 964

Human  1006 QLFNEINARKIHGERNVFD-GIFRNPIFCTIVLGTFAIQIVIVQFGGKPFSCSPLQL 1061
            .:||.::.|.  ..::||. |:..|.:|...|..:...|:::|.|       .|||:
  Fly   965 DMFNALSCRS--QTKSVFTIGLTTNRMFLLAVAFSIIGQMLVVYF-------PPLQM 1012

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP2B2	NP_001001331.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..24		5/22 (23%)
		ATPase-IIB_Ca	12..1087	CDD:273668	287/1151 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	334..381		2/46 (4%)
		Calmodulin-binding subdomain A. /evidence=ECO:0000250	1123..1140
		ATP_Ca_trans_C	1126..1172	CDD:463575
		Calmodulin-binding subdomain B. /evidence=ECO:0000250	1141..1150
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1194..1243
SPoCk	NP_001262220.1	P-type_ATPase_SPCA	139..1042	CDD:319779	273/1085 (25%)