Protein Alignment ATP2B2 and anne

DIOPT Version :10

• Sequence 1: NP_001001331.1
• Gene: ATP2B2 / 491
• HGNCID: 815
• Length: 1243
• Species: Homo sapiens
• Sequence 2: NP_001096849.1
• Gene: anne / 317815
• FlyBaseID: FBgn0052000
• Length: 1451
• Species: Drosophila melanogaster
• Alignment Length: 1248
• Identity: 246/1248 - (19%)
• Similarity: 397/1248 - (31%)
• Gaps: 463/1248 - (37%)

Human    67 GLPGTAPDLEKRKQIFGQN--FIPPKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYHPPGE 129
            |||  ..:...|:.:||.|  .:|.:..||.|.|  |.|....:..| .:.|:.....:|:
  Fly   322 GLP--VHEQISRRIVFGDNEITVPLRDFKTLLFL--EVLNPFYVFQL-FSVILWFTYDYYY---- 377

Human   130 GNEGCATAQGGAEDEGEAEAGWIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQE--QKF 192
                                   ....|||..:..:.|:.            ||::..|:  ||
  Fly   378 -----------------------YACVILLMSVFGITVSV------------LQTKKNQDVLQK- 406

Human   193 TVVRAGQ--VV-------QIPVAEIVVGDIAQV-KYGDLLPADGLFIQGNDLKIDESSLTGESDQ 247
            ||...|.  ||       ::|...||.|||.:: ..|..|..|.:.|.||.: :|||.|||||..
  Fly   407 TVYNTGNAWVVDHKGLSKELPTRAIVPGDIIEIPSSGCTLHCDAILISGNCI-LDESMLTGESVP 470

Human   248 VRKS---------VDKDP----MLLSGTHVME----GSGRMLVTAVGVNSQTGIIFTLLGAGGEE 295
            |.|:         .||..    .|..||.|::    ||.::|...:    .||.|
  Fly   471 VTKTPLPSKRDMIFDKTEHARHTLFCGTKVIQTRYIGSKKVLAFVI----NTGNI---------- 521

Human   296 EEKKDKKGVKKGDGLQLPAADGAAASNAADSANASLVNGKMQDGNVDASQSKAKQQDGAAAMEMQ 360
                                          :|...|:...:....||
  Fly   522 ------------------------------TAKGELIRSILYPPPVD------------------ 538

Human   361 PLKSAEGGDADDRKKASMHKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDTFVVNK 425
                              :|.|:.  ..|..:....|...|.:.:.:|.|
  Fly   539 ------------------YKFEQD--SYKFIQFLAIIACVGFIYTLVTKI--------------- 568

Human   426 KPWLPECTPVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETM 490
               |....|      ||..:..:.::.:.||..||.|:|:...|:.|::...........:....
  Fly   569 ---LRGTDP------VKIAVESLDLITIVVPPALPAAMTVGRFYAQKRLKTSEIFCISPRSINVA 624

Human   491 GNATAICSDKTGTLT--------------TNR-------------------------MTVVQA-Y 515
            |:....|.|||||||              ||:                         :|::.. .
  Fly   625 GSINCCCFDKTGTLTEDGLDMWGVVPKSSTNQFQIPLKSVDRLPFDHFLFGMVTCHSITILNGRM 689

Human   516 VGD-VHYK-------EIPDPSSI-NTKTMELLINAIAINSAYTTKILPPE--KEGALPRQVGNKT 569
            :|| :..|       |:.|.::| :|:...:|         |.|.:..|.  ..|....:.|:|.
  Fly   690 MGDPLDLKMFESTGWELEDSNNIPDTEKYGIL---------YPTILRQPRGGLSGMAETESGSKN 745

Human   570 ECGLLGFVLDLKQDYEPVRSQMP-EEKLYKVYTFNSVRKSMSTVIK-LPDESFRMYSKGASEIVL 632
            |......|.||........||.. :..:.:.:.|.|..:.||.|.: |.|:.|.:|.||:.| :|
  Fly   746 EIKRQSSVDDLLATVGISPSQKNFDHGIVREFPFTSALQRMSVVTRCLSDQVFNVYCKGSPE-ML 809

Human   633 KKCCKILNGAGEPRVFRPRDRDEMVKKVIEPMACDGLRTICVAYRDFPSSPEPDWD-----NEND 692
            ||.||            |:...:...:.:...|..|.|.|.:|::..  |.:.::.     :..:
  Fly   810 KKLCK------------PQSLPDNYSQQLSEFAKKGYRIIAIAFKAL--SHKMNYTKVQRLSREE 860

Human   693 ILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGE----- 752
            :.|.:..:..|.:|:.::|:..:.|.....|.|...|:|||||.||.::|..|||:.|.:
  Fly   861 VENNMEFLGFVILENRLKPDTTKVINALNAAKIRTIMITGDNILTAISVARDCGIVSPSQSVITV 925

Human   753 -------------------------------------------------------------DFLC 756
                                                                         :|..
  Fly   926 HADPIGDSANIQTNTGTECNFDNSSDKHYKLHYTLDLGSKTSRAYLFKSCFNSNLFDPETPEFTA 990

Human   757 LEGK-----EFNRRIRNEK----------------------------GEI-----------EQER 777
            ..||     |....:.||.                            .|:           .||.
  Fly   991 QVGKTIFHMESTNSLVNESTSSYAESGLPTSDSLASVKTIDTWTHNDAELGIKHTPDESWRRQEC 1055

Human   778 I----DKIWPKLR---------------VLARSSPTDKHTLVKGIIDSTHTEQRQVVAVTGDGTN 823
            |    .|.|..::               :.||.||..|..||   |:..:.:  ..||:.|||.|
  Fly  1056 IFAMDGKTWQIVKDYFPEEMEILLTRGSIYARMSPDQKQALV---IELQNLD--YCVAMCGDGAN 1115

Human   824 DGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDS---ISKFLQFQLTV 885
            |..|||.|..|.::......:   ||.....:...|:::|.:..||....:   |.|::.....|
  Fly  1116 DCGALKVAHAGISLSETEASI---ASPFTSRNPTISAVLKVIKEGRAALVTSFGIFKYMAAYSLV 1177

Human   886 NVVAVIVAFTGACITQDSPLKAVQMLWVNL-IMDTFASLALATEPPTETLLLRKPYGRNKPLISR 949
            ..::|::.:     :.||.|...|.|:|:| ::..||.....||.....|:.:.|.   ..|||.
  Fly  1178 QFISVMILY-----SIDSNLTDKQYLYVDLGLISIFAFFFGKTESFDGMLVEQVPL---SSLISS 1234

Human   950 TMMKNILGHAVYQLALIFTL----------------------LFVGEKMFQIDS----------G 982
            |.:.::|.|.....|...|.                      .|....||.|.|          .
  Fly  1235 TPLASLLLHLTVVTAFQVTCWVHLHQQPWFKAFEPADEDHLGCFENYTMFCISSFQYIILAFVFS 1299

Human   983 RNAPLHSPPSEHYTI----IFNTFVMMQLFNEINARKIHGERNVFDGIFRNPIFCTIVLGTFAIQ 1043
            :.||...|...::.:    |.|..:::.|.             ::...:....|..||..|...:
  Fly  1300 KGAPYRKPLWSNWPLCLAFIVNLCIIVYLV-------------LYPSDWVASFFQLIVPPTMRFR 1351

Human  1044 IVIVQFGGKPFSC 1056
            .|::.:|...|.|
  Fly  1352 YVMLAYGAASFIC 1364

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP2B2	NP_001001331.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..24
		ATPase-IIB_Ca	12..1087	CDD:273668	246/1248 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	334..381		2/46 (4%)
		Calmodulin-binding subdomain A. /evidence=ECO:0000250	1123..1140
		ATP_Ca_trans_C	1126..1172	CDD:463575
		Calmodulin-binding subdomain B. /evidence=ECO:0000250	1141..1150
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1194..1243
anne	NP_001096849.1	P5-ATPase	158..296	CDD:463565
		P-type_ATPase_cation	326..1281	CDD:319842	225/1144 (20%)