DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RyR and TRO

DIOPT Version :9

Sequence 1:	NP_001246211.1	Gene:	RyR / 49090	FlyBaseID:	FBgn0011286	Length:	5134	Species:	Drosophila melanogaster
Sequence 2:	NP_175556.1	Gene:	TRO / 841570	AraportID:	AT1G51450	Length:	509	Species:	Arabidopsis thaliana

Alignment Length:	409	Identity:	84/409 - (20%)
Similarity:	146/409 - (35%)	Gaps:	132/409 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   848 IEDDTAFVPKPVDTTGVTLPS----------SVDQIKEKLAENIHEMWALNKIEAGWSWG----- 897
            ||:....|..|.:.|||.|||          |.|.::|.: |...|......:..|.:.|
plant    19 IEEAQVSVSLPEEPTGVLLPSELVDDSAPPESSDAVEESI-ETASEAEVSISLLEGTTTGTALLP 82

  Fly   898 -EHRDDYHRIHPCLTHFEKLPAAEKRYDNQLAVQTLKTIISLGYYITMDKPPARIRPVRLPNEIF 961
             |..|        |...|.....|:..|..|  :.|..:.     :.:|:|.:   .:::.::.|
plant    83 SEEND--------LAPLESSGIIEEPIDTDL--EKLDVVA-----MDVDQPGS---DLKIESDSF 129

  Fly   962 MQGNGYKPAPLDLSAVT-LTPKLEELVDQLAENTHNLWARERIQQGWTYGLNEDSENHRSPH--- 1022
            .:     .||...|:.. .:|||:.:.:|      |..|.|. .:|       |.|....||
plant   130 SE-----EAPTTSSSDNPKSPKLDSVANQ------NGSAMEE-DEG-------DEEQDDPPHKKL 175

  Fly  1023 ---------------------------------LVPYAK-------------VDEAIKKANRDTA 1041
                                             ||..|.             |.::.:|..:.:.
plant   176 KQLDCLTSVAVKEEEEPEQVLPSEAMVVEEAATLVASAAKKSKSKKKNNNVWVTKSTRKGKKKSK 240

  Fly  1042 SETVRTLLVYGYVLDPPT------GEGTEAL------LAEAQRLKFA----------GFRTYRVE 1084
            :.|.....|...||..|.      |:.|..|      :.:|::::.:          |:|..|..
plant   241 ANTPNPAAVEDKVLITPVPRFPDKGDDTPDLEICLSKVYKAEKVEISEDRLTAGSSKGYRMVRAT 305

  Fly  1085 RNYAVTSGKWYFEFEVLT---SGPMRVGWARADCYPGAMLGSEDTSWAFDGHNEEKVYGGVSESF 1146
            |  .|..|.||||.:||:   :|..|:||:.......|.:|.:..|:.|...:..|::..:.|::
plant   306 R--GVVEGAWYFEIKVLSLGETGHTRLGWSTDKGDLQAPVGYDGNSFGFRDIDGCKIHKALRETY 368

  Fly  1147 GKQ-CGPGDIVGVFLDLAD 1164
            .:: ...||::|.:::|.|
plant   369 AEEGYKEGDVIGFYINLPD 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RyR	NP_001246211.1	Ins145_P3_rec	11..202	CDD:285871
		MIR	211..392	CDD:280906
		MIR	270..>305	CDD:197746
		RYDR_ITPR	443..636	CDD:279676
		SPRY1_RyR	647..799	CDD:240457
		RyR	854..944	CDD:280244	23/105 (22%)
		RyR	967..1057	CDD:280244	24/139 (17%)
		SPRY2_RyR	1079..1213	CDD:240458	26/90 (29%)
		SPRY3_RyR	1518..1669	CDD:293937
		RYDR_ITPR	2228..2452	CDD:279676
		RyR	2831..2921	CDD:280244
		RyR	2954..3038	CDD:280244
		RIH_assoc	4017..4130	CDD:285630
		RR_TM4-6	4525..4768	CDD:283990
		Ion_trans	4856..>4976	CDD:278921
TRO	NP_175556.1	SPRY_Ash2	284..471	CDD:293932	27/106 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000