DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RyR and ryr1a

DIOPT Version :9

Sequence 1:	NP_001246211.1	Gene:	RyR / 49090	FlyBaseID:	FBgn0011286	Length:	5134	Species:	Drosophila melanogaster
Sequence 2:	XP_021335080.1	Gene:	ryr1a / 798565	ZFINID:	ZDB-GENE-020108-2	Length:	5069	Species:	Danio rerio

Alignment Length:	5393	Identity:	2333/5393 - (43%)
Similarity:	3280/5393 - (60%)	Gaps:	595/5393 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 AEGGSEQDDVSFLRTEDMVTLSCTAT----GERVCLAAEGFGNRHCFLENIAD-KNVPPDLSQCV 63
            |||...::::.||||:|.|.|.||||    ..::||:.||||||.||||..:: :||||||:.|.
Zfish     2 AEGAEGEEEIQFLRTDDQVVLQCTATILKEQIKLCLSCEGFGNRLCFLETTSNAQNVPPDLAICC 66

  Fly    64 FVIEQALSVRALQELVT-------AAGSETGKGTGSGHRTLLYGNAILLRHHNSDMYLACLSTSS 121
            |::||:||||||||::.       |...:.....|.||||||||:||||||.:|.|||:||:||.
Zfish    67 FILEQSLSVRALQEMLANTTELNEAVDLDKWSSQGGGHRTLLYGHAILLRHTHSGMYLSCLTTSR 131

  Fly   122 S-NDKLSFDVGLQEHSQGEACWWTVHPASKQRSEGEKVRVGDDLILVSVATERYLHTTKENEQSI 185
            | .|||:|||||||.|.|||||||:||||||||||||||||||:|||||::|||||.:..:...:
Zfish   132 SLTDKLAFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRVGDDIILVSVSSERYLHLSYASGDLM 196

  Fly   186 VNASFHVTHWSVQPYGTGISRMKYVGYVFGGDVLRFFHGG-DECLTIPSTWGREAG---QNIVIY 246
            |:|||..|.|::.|..:|....:  |::.||.|||.|||. |||||||   |.|.|   :....|
Zfish   197 VDASFMQTLWNMNPVCSGCELAE--GFLTGGHVLRLFHGHMDECLTIP---GAEQGDDQRRNAHY 256

  Fly   247 EGGVVMAQARSLWRLELARTKWTGGFINWYHPMRIRHITTGRYLGVNDSNELILVKKEEASIATT 311
            |||.|.:.||||||||..|..|:|..:.|....|:|||||||||.:::...|::|..|:|:...:
Zfish   257 EGGAVCSHARSLWRLEPLRIGWSGSHMKWGQSFRVRHITTGRYLCLDEEKGLLIVDPEKANTKQS 321

  Fly   312 TFCLRQEKDDEKKVLEDKDLEVIGSPIIKYGDTTVIVQHCETSLWLSYKSYETKKKGVGKVEEKQ 376
            .||.|..| ::.:|.:.:|:|.:|.|.||||::...|||..|||||:|.|.:.|...:|.::.|
Zfish   322 AFCFRASK-EKTEVAQKRDVEGMGIPEIKYGESMCFVQHVATSLWLTYASVDAKSARLGPLKRK- 384

  Fly   377 AILHEEGKMDDCLDFSRSQEEESKTARVIRKCSSLFTQFITALETLQSNRRHSIFFQKVNLNEMV 441
            ||||:||.|||.|..:|||..||:.||:|...:.||||||..|::|....:.......:.|:.:|
Zfish   385 AILHQEGHMDDALTVARSQTAESQAARMIYNTAGLFTQFIKGLDSLSGKSKSPGPSPSLPLDAIV 449

  Fly   442 MCLEDLINYFSQPEDDMEHEEKQNRFRALRNRQDLFQEEGVLNLILEAIDKINIITSQGFLASFL 506
            :.|:|||.||..||:::||||||.:.|:|||||:||||||::.|:|:.:|::|:..:....:.|
Zfish   450 LSLQDLIFYFRPPEEELEHEEKQTKLRSLRNRQNLFQEEGMITLVLDCVDRLNVYNTSAHFSEF- 513

  Fly   507 AGDETGQSWDLISTYLYQLLAAIIKGNHTNCAQFANSNRLNWLFSRLGSQASSEGSGMLDVLHCV 571
            ||::..:||..|....|:|||::|:||..|||.|.::  |:||.|:|....:|  ||:|:||:|:
Zfish   514 AGEDAAESWKEIVNLFYELLASLIRGNRANCALFCDN--LDWLVSKLDRLEAS--SGILEVLYCI 574

  Fly   572 LIDSPEALNMMRDEHIKVIISLLEKHGRDPKVLDVLCSLCVGNGVAVRSSQNNICDFLLPGKNLL 636
            ||:|||.||::::.|||.||:||:||||:.|||||||||||.|||||||:||.|.:.||||::||
Zfish   575 LIESPEVLNIIQENHIKSIIALLDKHGRNHKVLDVLCSLCVCNGVAVRSNQNLITENLLPGRDLL 639

  Fly   637 LQTLLVDHVASIRPNIFVGRVDGSSMYQKWYFEVTMDHIEQ--TTHMMPHLRIGWANTSGYVPYP 699
            |||.::::|.|:|||||:|..:||:.|:|||:|:.:||:|.  |.|.. |||:|||.|.||.|||
Zfish   640 LQTNIINYVTSMRPNIFLGTCEGSTQYKKWYYELIVDHVESFLTAHPF-HLRVGWALTEGYSPYP 703

  Fly   700 GGGKKWGGNGVGDDLYSFGFDGAFLWTGGRKTLVVDALPEEPFIRKGDVIGVAIDLSVPIITFTF 764
            |||:.||||||||||:|:||||..||||.....|..  |.:..:...||:...:|||||.|:|..
Zfish   704 GGGEGWGGNGVGDDLHSYGFDGLNLWTGRVPRQVTS--PSQHILSAEDVVSCCLDLSVPSISFRI 766

  Fly   765 NGVKVRGSFRDFNLDGMFFPVMSCSSKLSCRFLFGGDHGRLKFAPPMGFSALVQCLMPQQILSLD 829
            ||..|:|.|.:|||||:||||:|.|:.:..|||.||..|..||.||.|::...:.::|:..|.::
Zfish   767 NGHPVQGMFENFNLDGLFFPVVSFSAGIKVRFLLGGRQGDFKFLPPPGYAPCYEAVLPKDRLRIE 831

  Fly   830 PC--FYFGNLAKNVLAGPWLIEDDTAFVPKPVDTTGVTLPSSVDQIKEKLAENIHEMWALNKIEA 892
            |.  :...|.....|.||......|||.|.||||..:.||..:::|:||||||.||:||:.:||.
Zfish   832 PIKEYKHDNDGVRNLLGPTQSLSHTAFTPCPVDTVQIVLPPHLERIREKLAENSHELWAVTRIEQ 896

  Fly   893 GWSWGEHRDDYHRIHPCLTHFEKLPAAEKRYDNQLAVQTLKTIISLGYYITM--DKPPARIRPVR 955
            ||::|..|||..::||||..|:.||..||.|:..::.:||||:::||.::.|  :|....::.::
Zfish   897 GWTYGLFRDDNKKLHPCLVDFQSLPDPEKSYNLAMSGETLKTLLALGCHVGMGDEKAEENLKKIK 961

  Fly   956 LPNEIFMQGNGYKPAPLDLSAVTLTPKLEELVDQLAENTHNLWARERIQQGWTYGLNEDSENHRS 1020
            || :.:||.||||||||||:.|.|||....||::||||.||:|||:|::|||||.:.:|..|.|:
Zfish   962 LP-KTYMQCNGYKPAPLDLNHVKLTPNQNTLVERLAENGHNVWARDRVRQGWTYSIIQDIVNKRN 1025

  Fly  1021 PHLVPYAKVDEAIKKANRDTASETVRTLLVYGYVLDPPTGEGTEALLAEAQRLKFAGFRTYRVER 1085
            |.||||..:||..||.||||....||||:.|||.::||..|.:.......:..|   .|.:|.|:
Zfish  1026 PRLVPYILLDEKTKKTNRDTVCAAVRTLIGYGYNIEPPDQESSGHGGGNGRSDK---IRVFRAEK 1087

  Fly  1086 NYAVTSGKWYFEFEVLTSGPMRVGWARADCYPGAMLGSEDTSWAFDGHNEEKVYGGVSESFGKQC 1150
            :||||.||||||||.:|.|.|||||||...:....|||:|.::.|:|...::.:.| :|.||:|.
Zfish  1088 SYAVTQGKWYFEFEAVTVGEMRVGWARPSVHADRELGSDDLAYVFNGFKSQRWHIG-NEPFGRQW 1151

  Fly  1151 GPGDIVGVFLDLADHTISFSLNGELLMDALGGETTFADVTAEGVGFVPACTLGVGQKARLIYGQD 1215
            ..||:||..:||.:..|.|:||||:|:...|.|..|.|:.. |.||:|.|:||:.|..|:..||:
Zfish  1152 QSGDVVGCMIDLTEQNIMFTLNGEMLISDSGSEMAFKDIEI-GEGFIPVCSLGMSQVGRINLGQN 1215

  Fly  1216 VDSLKFFTTCGLQEGYEPFCVNMRRPVTHWYTKDQPIFENT-EEMPDCRIDVTRIPGGADTPPHL 1279
            |.||::||.||||||:|||.:||:|.:|.|::|..|.|... .:.|  .|:|:|:.|..::.|.|
Zfish  1216 VSSLRYFTICGLQEGFEPFAINMKRDITMWFSKSLPQFVPVPTDHP--HIEVSRVDGTVESAPCL 1278

  Fly  1280 KISHNTFETMEKANWE--FLRLSLPVTCMGEFISEQEKARRWDEIKNRQYRLMREAEIAAQMQVQ 1342
            |::|.||.: :.||.:  |.|||:|:    ||              :..:::
Zfish  1279 KLTHRTFGS-QNANTDLLFFRLSMPI----EF--------------HETFKV------------- 1311

  Fly  1343 TQAAHMDHMLKGGFNMNDIKGLTRNFDEHADAEADHMMRGPNRPPRKGSLTRNITFETDMSAALD 1407
                                                       |.....|||.:|...|.:..:|
Zfish  1312 -------------------------------------------PVGASPLTRTLTIPEDETLEVD 1333

  Fly  1408 EMQRSTSVLDMNGLGEEMDDKKKRGRSPFKF----FSKKSRDQSREKMGARTLDTSLERRNTVAH 1468
            . :....:|..:...:|.|:|:|....|.:.    .|:..:|.:.||...|...:..::...:|
Zfish  1334 P-ESEFELLKKSATRKEQDEKEKEPSVPKELPGSKESENEKDTTTEKSKKRGFFSKAKKAAFIA- 1396

  Fly  1469 GRNVVNQQMTTRAPTLRLNNAEIPPSPVPQGPKQLSGSNLGQQPVETSGDEMFDAECLKLINEYF 1533
                                   ||..||..|:.:.         :...|:..|.|.:.....|:
Zfish  1397 -----------------------PPPVVPTMPRLME---------DVVPDDRDDVEIISNTTTYY 1429

  Fly  1534 YGVRIFPGQDPTHVYVGWVTTQYHLHSREFNKNKVRRGSVYIEDDYEMAIERIDRQSCYVVRADE 1598
            |.||:|.||:|:.|:|||||..|||:...|:..|||..:|.:.||.....:.:.|.:||:|...|
Zfish  1430 YSVRVFAGQEPSGVWVGWVTPDYHLYDLHFDLCKVRNVTVTVGDDKGNIHDSVKRSNCYMVWGGE 1494

  Fly  1599 LFNEVTQDASGKGASQGMFVGCFVDTATGIIRFTCEGKDTSHRWMMEPDTKLFPAIFVEATSKEI 1663
             |:...|.   :.:.:...:||.||..||::.||..||:.:..:.:||:||||||:|...:|:.:
Zfish  1495 -FSSSQQT---RISQEDFVIGCLVDLDTGLMTFTANGKEINTFYQVEPNTKLFPAVFCLPSSQNM 1555

  Fly  1664 LQIELGRTPTTLPLSAAVLPTSDKHINPQSPPRLKVQCLRPHQWARVPNTALQVHALKLSDVRGW 1728
            ||:|||:....:|:|||:..:..|:..||.||||.:|.|.|..|:|:||..|.....::|:.:||
Zfish  1556 LQVELGKLKNIMPISAAMFRSDCKNPVPQCPPRLDLQMLTPVIWSRMPNHFLSPETGRVSERQGW 1620

  Fly  1729 SMLCEDPVSMLALHIPEEDRCIDILELIEMDKLLSFHAHSLTLYAALCYQSNYRAAHALCQHVDQ 1793
            .:.|.:|:.|:|||||||:||||||||.|...|:.||.|:|.||.::|...|.|.|||||.|||:
Zfish  1621 KVQCMEPLVMMALHIPEENRCIDILELSERTDLMKFHYHTLKLYGSVCALGNNRVAHALCSHVDE 1685

  Fly  1794 KQLLYAIRSEYMSGPLRQGFYDLLIALHLESHATTMEVCKNEYITPLGAELKE--LYSDEEMQHS 1856
            .||.|||.:.|:.||:|.|:|||||::||||......:...|:|.|:..|.:.  ||||.|..|:
Zfish  1686 SQLFYAIENTYLPGPIRSGYYDLLISMHLESAKRNRLMTNKEFIVPMTDETRSITLYSDAEKAHA 1750

  Fly  1857 LRSL-VTESVRPQLRMTEITPPVIATSSMPSVSSEPIPDIDQLY--SPKFPLEVVRQFVMEALKD 1918
            |..: :|..:||:|.        .|.:.....:::       ||  ||..||::::...:..|.:
Zfish  1751 LPGVGLTTCLRPKLH--------FAPTGFVGTNAD-------LYTLSPMLPLQMLKDHALSMLTE 1800

  Fly  1919 AVEINQVHNRDPIGWTNENLFLPLIKLTDRLLLVGVLTDEDVQRLLVMIDP-------------- 1969
            ||:......|||:|.:.|..|:|::||...||::||..|:||:.:|.:|:|
Zfish  1801 AVQDGGQAIRDPVGGSVEYHFVPILKLISTLLIMGVFDDDDVKHILKLIEPSVFSSNSETPAEET 1865

  Fly  1970 ----------------------------------------------ETWDQAFEREGK---DEHR 1985
                                                          |..|:.:|.|.|   |||.
Zfish  1866 GDPEQQLVCKEEGAEVKEQEEPADGGNDGELLDEGMGEEEELEEEEEEEDEEYEEEVKKEEDEHA 1930

  Fly  1986 --------------------------------KGLLTMKMAEGAKLQMCYLLHHLYDTQLRHRVE 2018
                                            :|||.||:.|..|||||.||.:..|.:||||||
Zfish  1931 AEKTDREKTTDGETEKETGAAEAEVREEEDVGEGLLHMKLPESVKLQMCTLLQYFCDCELRHRVE 1995

  Fly  2019 SIIAFSHDFVGDLQTDQLRRYIEIKQS-DLPSAVAAKKTKEFRCPPREQMNQILCFKNLEPDDQD 2082
            :|||||..||..:||:|.:||.|:.|: .:.:|..|:||:|||.||:||:|.::.|||. |:::|
Zfish  1996 AIIAFSDKFVNQVQTNQRQRYNELMQAFTMSAAETARKTREFRSPPQEQVNMLMNFKNC-PEEED 2059

  Fly  2083 NCTCGLELRGRLGDFHDSLMQKVSLNALQEPDGVEGTAIEEVKTGPITKIYNFINTVKELEEGPK 2147
             |....::|..|..||..|:....::..:|...      |||.|....::...:..||.|.:.|:
Zfish  2060 -CPVPEDVRNGLLTFHHDLLAHCGVHIEEEEQE------EEVDTSLSGRLRRLVEKVKSLRKKPE 2117

  Fly  2148 EVEEPEKKTPEEVFRKVLIKTIVSWAEESQIENPKLVREMFSLLLRQYDTVGELVRALEKTYVIN 2212
            ...|||:.......::::..|::.||:||.|:||:|||.|||||.||||.:|||:|||.|.|:||
Zfish  2118 AEPEPEEDKKPSTLQELISHTMIYWAQESFIQNPELVRLMFSLLHRQYDALGELIRALPKAYIIN 2182

  Fly  2213 TRARDDVAEMWVGLSQIRALLPVQMSQEEEELMRKRLWKLVNNATFFQHPDLIRILRVHENVMAV 2277
            ..:..|..|:...|.|||:||.|||..|||.||.:.:..:::|..|:|||:|:|.|.:||.||.|
Zfish  2183 AVSIQDTMELLECLGQIRSLLIVQMGPEEERLMIQSIGNIMSNRVFYQHPNLMRALGMHETVMEV 2247

  Fly  2278 MMNTLGRRAQAQSDAPTQSEVAEGAPSKEKDTSHEMVVACCRFLCYFCRTGRQNQKAMFDHFDFL 2342
            |:|.||                 |..||| .....||..||||||||||..||||::||||..:|
Zfish  2248 MVNVLG-----------------GGDSKE-IRFPRMVTNCCRFLCYFCRISRQNQRSMFDHLGYL 2294

  Fly  2343 LDNANILLARPSLRGSTPLDVAYSSLMENTELALALREHYLEKIAVYLSRCGLQSNSELVEKGYP 2407
            |.|:.|.|   .:|||||||||.:|.::|.||||||:|..||.:..||:.|||||...|:.||||
Zfish  2295 LQNSGIGL---GMRGSTPLDVAAASCIDNNELALALQEQDLEMVVKYLAGCGLQSCPMLLSKGYP 2356

  Fly  2408 DLGWDPVEGERYLDFLRYCVWVNGESVEENANLVIRLLIRRPECLGPALRGE-GEGLFRAIVEAN 2471
            |:||:||.||:||||||:.|:|||||||||||:|:|||||||||.||||||| |.||..||.||.
Zfish  2357 DIGWNPVGGEKYLDFLRFAVFVNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAAIEEAI 2421

  Fly  2472 RMSERISDRCKMQDEA-EGTIAGLNFTHPLPEGEE--DEDYIDTGAAILNFYCTLVDLLGRCAPD 2533
            ::||         |.| :|.....:...|:..|||  :|:.:..|.||::||..|:||||||||:
Zfish  2422 KISE---------DPARDGPTVKKDRRFPMFGGEEQHEENRVHLGNAIMSFYSALIDLLGRCAPE 2477

  Fly  2534 ASVIEQGKNESLRARAILRSLVPLEDLQGVLSLKFTLSQTAPGEE----KPKSDMPSGLLPNNKQ 2594
            ..:|:.||.|:||.|||||||||:|||.||:||...:  .|.|::    :||  |.:..:|::|.
Zfish  2478 MHLIQAGKGEALRIRAILRSLVPIEDLVGVISLSVQI--PAFGKDNSIIEPK--MSASFVPDHKA 2538

  Fly  2595 SIVLFLERVYGIEAQDLFYRLLEDAFLPDLRTATILDKSDGSESDMALAMNRYIGNSILPLLIKH 2659
            .:||||:|||||:.||....:||..||||:|.|..||.:..|.::||||:|||:.:::|||:.|.
Zfish  2539 PMVLFLDRVYGIDNQDFLLHVLEVGFLPDMRAAASLDTAAFSTTEMALALNRYLCSAVLPLITKC 2603

  Fly  2660 SKFYNEAENYASLLDATLHTVYRLSKNRMLTKGQREAVSDFLVALTSQMQPAMLLKLLRKLTVDV 2724
            :..:...::.|.::|:.|||:||||:.|.|||.||:.:.:.|::|...::|:||..|||:|..||
Zfish  2604 APLFAGTDHRAIMIDSMLHTIYRLSRGRSLTKAQRDVIEECLMSLCRYLRPSMLQHLLRRLVFDV 2668

  Fly  2725 SKLSEYTTVALRLLTLHFDRCAKYYGSTQGQGSYGASSDEEKRLTMLLFSNIFDSLSNMDYDPEL 2789
            ..|:||..:.|:|||.|::||.|||....|..::|.||:||..||..||..||:||::..:|.||
Zfish  2669 PILNEYAKMPLKLLTNHYERCWKYYCLPNGWANFGVSSEEELHLTRKLFWGIFESLAHKKFDAEL 2733

  Fly  2790 FGKALPCLIAIGCALPPDY---SLSKNTDEDYYGRQMGAPDQPQYMPNPIDTNNVHLDNDLNSLV 2851
            |..|:||:.||..|:||||   |.|..|:     ::.....:..:.|.|:||.|..:...|:..:
Zfish  2734 FKIAMPCICAIAGAIPPDYVDASYSSKTE-----KKASVDAEGNFDPKPVDTTNTIIPEKLDGFI 2793

  Fly  2852 QKFSEHYHDAWASRRLEGGWTYGDIRSDNDRKHPRLKPYNMLSEYERERYRDPVRECLKGLLAIG 2916
            .:::|:.||.||..:::..||:|::..:|.:.||.|:||...||.::|.||.|::|.:|.::|..
Zfish  2794 NRYAEYTHDRWAFEKIQNNWTFGEVMDENAKTHPMLRPYKTFSEKDKEIYRWPIKESIKAMIAWE 2858

  Fly  2917 WTV------EHSEVEVALNHRGSTRRQSK-PQINEFQNEGSPFNYNPHPVDMSNLTLSREMQNMA 2974
            ||:      |..:||     :.:.|:.|: .|.....:.|    |:|.|:|:|.:|||||:|:||
Zfish  2859 WTLDKARDGEDEKVE-----KKTARKISQTAQATYDPSHG----YSPQPIDISGMTLSRELQSMA 2914

  Fly  2975 ERLAENSHDIWAKKKNEELNGCGGVIHPQLVPYDLLTDKEKKKDRERSQEFLKYMQYQGYKLHKP 3039
            |:||||.|:.|.:||..||...||..||.|||||.||.|||.:|||::.|.||::|..||.:.:
Zfish  2915 EQLAENYHNTWGRKKKMELQAKGGGTHPLLVPYDTLTAKEKARDREKAYELLKFLQLNGYAVTR- 2978

  Fly  3040 SKGGAVEEGGATQAAVELRFSYSLLEKLIQYLDRATINMKLLKPSTTFSRRSSFKTATRDIKFFS 3104
                .:::..:..:::|.||:|..|:||::::|.|...:..|: :...|.|.......::||||:
Zfish  2979 ----GLKDMESDISSIEKRFAYGFLQKLLKWMDIAQEFIAHLE-AVVSSGRVEKSPHEQEIKFFA 3038

  Fly  3105 KVVLPLMEKYFSTHRNYFIAI-ATATNNIGAASLKEKEMVASIFCKLAALLRNRLSAFGPDVRIT 3168
            |::|||:.:||..|..||::. |....:.|.||.|||||:||||||::||:|:|:..||.|....
Zfish  3039 KILLPLINQYFKNHCLYFLSTPAKILGSGGHASNKEKEMIASIFCKMSALVRHRVFLFGTDAPAI 3103

  Fly  3169 VRCLQVLVKGIDARTLTKNCPEFIRTSMLTFFNQTSDDLGNTILNLQDGKYSHLRGTHLKTSTSL 3233
            |.||.:|.:.:||||:.|:.||.::..:..||...:||:...:.||:.||.|.........|.::
Zfish  3104 VNCLHILARSLDARTVMKSGPEIVKAGLRLFFESAADDIEKMVENLKLGKVSKGNQPVKGVSQNI 3168

  Fly  3234 GYVNQVVLPVLTAMFDHLAACDYGSDLLLDEIQVASYKILAALYHLGTDGTLTHDRKYLKT-EIE 3297
            .|....:|||||::|||:|...:|.|::||::|::.|:|:.::|.|||          :|| ..|
Zfish  3169 NYTTTALLPVLTSLFDHIAQHQFGDDVILDDLQMSCYRIMCSIYSLGT----------VKTPHAE 3223

  Fly  3298 RHRPALGSCLGAYSSCFPVAFLEPHLNKHNQYS--------------LLNRIADHSLEAQDIMVK 3348
            |||||||.||...::..|||:||||||::|.:|              |.|::.:..|:
Zfish  3224 RHRPALGECLAHLAAAMPVAYLEPHLNEYNAFSVYTTKTPRERAILGLPNQVQELCLD------- 3281

  Fly  3349 MESCMPNLETILAEVDQFVESDKTYNDAPHIIDVILPLLCAYLPFWWSQGPDNVSPTSGNHVTMV 3413
                :|.|:.:|.|:....||...|.:.||:|:|.||:||.|||.||.:|.:|.....|...|.|
Zfish  3282 ----IPELDVLLKEIGDLAESGARYTEMPHVIEVTLPMLCNYLPRWWERGLENFPDLEGKLCTDV 3342

  Fly  3414 TADHMNPLLRNVLKMIKKNIGNDNAPWMTRIAAYTQQIIINTSEELLKDPFLPLAERVKKRTENM 3478
            |::.:|.||.:::|::..|:|.|.|.||.|:|.::|.|:.....|:||..|:|..|::||||..:
Zfish  3343 TSESLNQLLGSIMKIVVNNLGIDEASWMKRLAVFSQPIVSRAKPEMLKSHFIPTMEKLKKRTSKV 3407

  Fly  3479 LHKEDSMRGFIKSATDDTSQVETQLQEDWNLLVRDIYSFYPLLIKYVDLQRNHWLKDNIPEAEEL 3543
            :.:|:.:|...||..|:.   |..:::::.:|.||:|:.|||||:|||..|..||....|:||||
Zfish  3408 VAEEEHLRLEGKSEGDEE---EGTIRDEFAVLCRDLYALYPLLIRYVDNNRARWLTFRDPDAEEL 3469

  Fly  3544 YNHVAEIFNIWSKSQYFLKEEQNFISANEIDNMALIMPTATRRSAISEG--APAVGGKVKKKKKN 3606
            :..|.|:|..||||..|.:|||||:..|||:||:.:  ||..:|.:|:.  :.|.|..|::.||
Zfish  3470 FRMVGEVFIFWSKSHNFKREEQNFVVMNEINNMSFL--TADSKSKMSKAGDSEAGGSDVERTKK- 3531

  Fly  3607 RDKKRDKDKEVQASLMVACLKRLLPVGLNLFAGREQELVQHCKDRYLKKMPEYDVIEFARNQLTL 3671
              |:|.....||.||:||.||::||:|||:.:..:|||:...|.||..|..:.:|.||.:|.|.|
Zfish  3532 --KRRGDRYSVQTSLIVAALKKMLPIGLNMCSPADQELINLAKTRYSLKDTDEEVREFLQNNLHL 3594

  Fly  3672 PDKLD-PSDEMSWQHYLYSKL-GKTEEPVDEQALEKANVNSNEKGKDKTQETVDRIVAMAKVLFG 3734
            ..|:| ||  |.||..||.:: ||.|:                  .|..:..|.|:..::.||:.
Zfish  3595 QGKVDNPS--MRWQMALYKEMAGKAED------------------ADAPENVVKRVQEVSAVLYH 3639

  Fly  3735 LHMAASS-KNRSKRWGSKISVARRQAVISSLRAKHLYRMSRHRACNIFARSYYEQWLQEENVG-Q 3797
            :.:.... |::...|...:|..||:||::..|...||.:.||||.|:|...|...|::.|... :
Zfish  3640 IEVTEHPFKSKKMVWHKLLSKQRRRAVVACFRMTPLYNLPRHRASNMFLDGYKRNWIRNEGYSFE 3704

  Fly  3798 EVMVEDLTQTFEDSEKSKKEGEETDSKPDPLTQLVTTFCRGAMTERSGALQEDLLYMSYAQIAAK 3862
            :.|::||::..|:.|   :|.||.::|||||.||:..|.|.|:||:| .|..|.|||:||.|.||
Zfish  3705 DRMIDDLSKALEEEE---EEEEEKETKPDPLHQLILHFSRTALTEKS-KLDIDHLYMAYADIMAK 3765

  Fly  3863 STGKEEEEGGDEEGGEGGEEGEGTSIHEQEMEKQKLLFHQARLSNRGVAEMVLLHISASKGIPSE 3927
            |...:||:.|.||..||||  |..|..|:|||||:||:.|:||.|||.|||||..|||.||....
Zfish  3766 SCHMDEEDEGGEEENEGGE--EEMSFEEKEMEKQRLLYQQSRLHNRGAAEMVLQMISACKGETGC 3828

  Fly  3928 MVMTTLNLGIAILRGGNIDIQMGMLNHLKEKKDVGFFTSIAGLMNSCSVLDLDAFERNTKAEEYI 3992
            ||.:||.|||:||.|||.::|..||::||:|||||||.|:..||.:||||||:||||..|||
Zfish  3829 MVSSTLKLGISILNGGNCEVQQKMLDYLKDKKDVGFFLSVQALMQTCSVLDLNAFERQNKAE--- 3890

  Fly  3993 PSAGAGLGVGSEGAA------GEKNMHDAEFTCALFRFIQLTCEGHNLEWQNYLRTQAGNTTTVN 4051
                 |||:.||...      |||.|.|.||||.||||:||.|||||.::|||||||.|:|||:|
Zfish  3891 -----GLGMVSEEGTNMKLERGEKVMADDEFTCDLFRFLQLLCEGHNNDFQNYLRTQTGSTTTIN 3950

  Fly  4052 VVICTVDYLLRLQESIMDFYWHYSSKEIIDPAGKANFFKAIEVASQVFNTLTEVIQGPCTLNQQA 4116
            |:||||||||||||||.||||:||.|:|||..||.||.||:.||.||||:|||.||||||.|||:
Zfish  3951 VIICTVDYLLRLQESISDFYWYYSGKDIIDEPGKRNFSKAMTVAKQVFNSLTEYIQGPCTGNQQS 4015

  Fly  4117 LAHSRLWDAVGGFLFLFSHMQDKLS--KHSSQVDLLKELLNLQKDMITMMLSMLEGNVVNGTIGK 4179
            ||||||||||.|||.:|:||..||:  :.|||:.||||||:|||||:.|:||:||||||||||.:
Zfish  4016 LAHSRLWDAVVGFLHVFAHMMMKLAQGRDSSQIGLLKELLDLQKDMVVMLLSLLEGNVVNGTIAR 4080

  Fly  4180 QMVDTLVESASNVELILKYFDMFLKLADLIESPSFHEVDMKNEGWVTPKDFREKMEQSKNYTPEE 4244
            ||||.||||:||||:|||:|||||||.|::.|.:|.:......|.::.|||::.|:..|.|||.|
Zfish  4081 QMVDMLVESSSNVEMILKFFDMFLKLKDIVASDAFRDYVTDPRGLISKKDFQKSMDSQKQYTPSE 4145

  Fly  4245 MDFLLACCERNHEGKIDYRAFVEHFHEPSKEIGFNLAVLLTNLSEHMPNEPRLARFLETAGSVLN 4309
            :.|||:|.|.:....|:|..|...|.||:|:||||:||||||||||:|::.||..|||.|.||||
Zfish  4146 IQFLLSCSEADENEMINYEEFASRFQEPAKDIGFNIAVLLTNLSEHVPHDTRLQNFLEQAESVLN 4210

  Fly  4310 YFEPFLGRIEILGSSKRIERVYFEIKDSNIEQWEKPQIRESKRAFFYSIVTEGGDKEKLEAFVNF 4374
            ||.||||||||:|:|::|||:||||.:.|.:|||.||::||||.|.:.:|.|||:.||:|.||||
Zfish  4211 YFRPFLGRIEIMGASRKIERIYFEISEVNRKQWEMPQVKESKRQFIFDVVNEGGESEKMELFVNF 4275

  Fly  4375 CEDAIFEMTHASGLMATDDGGGNVKRDTAYSSYMSEEEEERAARDPIRRTITAVKEGLKFG---- 4435
            |||.||||..|                    |.:||::||....|.|...     ||...|
Zfish  4276 CEDTIFEMNIA--------------------SQISEQDEEEKEEDDIEEA-----EGGDAGDEEG 4315

  Fly  4436 -----------------------VHMLSPANIKHQIGVMQTKSIPELIVGFFKIIFYIFYYTGYA 4477
                                   :.|.:..||:.:...::..:|.|::||....::.|.  .|..
Zfish  4316 GGEEGQPESSSAFADFIQSIMNFLGMFTFRNIRRKYRRLRKMTIKEIVVGLATFMWTIL--LGIL 4378

  Fly  4478 HF--CVVRYIFGILLNLMRG-------------------PAPEQEE-------EPVVEEETFGRA 4514
            ||  .|.:..|.::.:.:.|                   |.|.|:|       ||...||
Zfish  4379 HFIYSVCKGFFLLIWHTLFGGGLVEGAKNITVTELLASMPDPTQDEVHGDLPGEPRGGEE----- 4438

  Fly  4515 LPPLPLEEPPGTVQAFGL--------DINKEENGMYKV-----------VVHESPANSSMEEG-- 4558
                  :|..|.:.:...        ||.:::.|  |:           :...:|......||
Zfish  4439 ------QETGGIMDSMDAGGGEEEDEDIQEKDGG--KIPGIDTPGGLGDMGDTTPVEPPTPEGTP 4495

  Fly  4559 ---GESSPEDGAAASGELVEGEPHQEPISIVDLLGGEAAKKAAQERQEAQKAQEAAMASIEAEAK 4620
               .::.|::..|.....:| ||..|| ...|:..||.|:|..:.:.|....:.....:.:|:.:
Zfish  4496 LLKRKAQPDEAGAEQPPAIE-EPPPEP-EKADIENGEKAEKEVEVKPEPIPEEPKPQRATKAKKE 4558

  Fly  4621 KSSSAPQETPAVHQIDFSQYTHRAVSFLARNFYNLKYVALVLAFSINFMLLFYKVTSFTEEADSS 4685
            |.|.........:::|..:  ::.::.|:|||||::::||.|||::||:||||||:.....:|..
Zfish  4559 KKSVKGAGFELWNELDVQR--NKFMNCLSRNFYNIRFLALFLAFALNFILLFYKVSDTPPSSDEF 4621

  Fly  4686 AEEELILGSG--SGGGADITGSGFGGSGDGGSGDGEMEDEIPELVHVDEDFFYMEHVLRIAACLH 4748
            ....:..|||  .|...|..|||    |:.| ||.| ::|.|....::|...||:..|...|.||
Zfish  4622 EGSGIFEGSGLFEGSAEDFEGSG----GEDG-GDDE-DEEGPVYYFLEESTGYMQPTLSFLAILH 4680

  Fly  4749 SLVSLAMLIAYYHLKVPLAIFKREKEIARRLEFEGLFIAEQPEDDDFKSHWDKLVISAKSFPVNY 4813
            ::::...:|.|..||:||.|||||||:||:|||:||:|.|||.|||.|..||:||::..|||.||
Zfish  4681 TVIAFISIIGYNCLKIPLVIFKREKELARKLEFDGLYITEQPADDDIKGQWDRLVLNTPSFPTNY 4745

  Fly  4814 WDKFVKKKVRQKYSETYDFDSISNLLGME--------KSTFAAQESEETGIFKYIMNIDWRYQVW 4870
            ||||||:||..||.:.|..:.|:.||||:        :.|....|..:..:..:..:||.:||:|
Zfish  4746 WDKFVKRKVLDKYGDIYGRERIAELLGMDLASLDVSKQQTDKKPEEPDNSMLAWFTSIDIKYQIW 4810

  Fly  4871 KAGVTFTDNAFLYSLWYFSFSVMGNFNNFFFAAHLLDVAVGFKTLRTILQSVTHNGKQLVLTVML 4935
            |.||.||||.|||.:||...|::|::||||||.||||:|:|.|||||||.|||||||||::||.|
Zfish  4811 KFGVVFTDNTFLYLVWYTVMSLLGHYNNFFFACHLLDIAMGVKTLRTILSSVTHNGKQLMMTVGL 4875

  Fly  4936 LTIIVYIYTVIAFNFFRKFYIQEEDE-EVDKKCHDMLTCFVFHLYKGVRAGGGIGDEIGDPDGDD 4999
            |.::||:|||:|||||||||.:.||| |.|.||.||:||::||:|.||||||||||||.||.||:
Zfish  4876 LAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDE 4940

  Fly  5000 YEVYRIIFDITFFFFVIIILLAIIQGLIIDAFGELRDQLESVKDNMESNCFICGMGKDFFDIVPH 5064
            ||:||::||||||||||:||||||||||||||||||||.|.||::||:.|||||:|.|:||..||
Zfish  4941 YELYRVVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPH 5005

  Fly  5065 GFDTHVQKEHNLANYMFFLMHLINKPDTEYTGQETYVWNMYQQRSWDFFPVGDCFRKQYEDEL 5127
            ||:||..:||||||||||||:||||.:||:||||:|||.|||:|.|||||.||||||||||:|
Zfish  5006 GFETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQL 5068

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RyR	NP_001246211.1	Ins145_P3_rec	11..202	CDD:285871	119/203 (59%)
		MIR	211..392	CDD:280906	86/184 (47%)
		MIR	270..>305	CDD:197746	14/34 (41%)
		RYDR_ITPR	443..636	CDD:279676	102/192 (53%)
		SPRY1_RyR	647..799	CDD:240457	83/153 (54%)
		RyR	854..944	CDD:280244	43/89 (48%)
		RyR	967..1057	CDD:280244	52/89 (58%)
		SPRY2_RyR	1079..1213	CDD:240458	61/133 (46%)
		SPRY3_RyR	1518..1669	CDD:293937	57/150 (38%)
		RYDR_ITPR	2228..2452	CDD:279676	125/223 (56%)
		RyR	2831..2921	CDD:280244	31/95 (33%)
		RyR	2954..3038	CDD:280244	47/83 (57%)
		RIH_assoc	4017..4130	CDD:285630	86/112 (77%)
		RR_TM4-6	4525..4768	CDD:283990	73/268 (27%)
		Ion_trans	4856..>4976	CDD:278921	76/120 (63%)
ryr1a	XP_021335080.1	Ins145_P3_rec	11..211	CDD:312293	118/199 (59%)
		MIR	220..399	CDD:308455	86/183 (47%)
		RYDR_ITPR	451..642	CDD:307497	105/195 (54%)
		SPRY1_RyR	650..801	CDD:240457	83/153 (54%)
		RyR	858..948	CDD:307927	43/89 (48%)
		RyR	972..1062	CDD:307927	52/89 (58%)
		SPRY2_RyR	1081..1213	CDD:240458	61/133 (46%)
		SPRY3_RyR	1420..1561	CDD:293937	55/144 (38%)
		RYDR_ITPR	2196..2406	CDD:307497	130/230 (57%)
		RyR	2773..2863	CDD:307927	31/89 (35%)
		RyR	2894..2978	CDD:307927	47/83 (57%)
		RIH_assoc	3916..4029	CDD:312080	86/112 (77%)
		EF-hand_8	4122..4172	CDD:316358	19/49 (39%)
		RR_TM4-6	4416..4700	CDD:310808	82/306 (27%)
		Ion_trans	4793..4980	CDD:306908	129/186 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580208
Domainoid	1	1.000	713	1.000	Domainoid score	I112
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37423
Inparanoid	1	1.050	4145	1.000	Inparanoid score	I4
OMA	1	1.010	-	-		QHG46584
OrthoDB	1	1.010	-	-		D4054at33208
OrthoFinder	1	1.000	-	-		FOG0001801
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102727
Panther	1	1.100	-	-	O	PTHR13715
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1009
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910